Protein Alignment ACVR1 and daf-1

DIOPT Version :9

• Sequence 1: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_001023159.1
• Gene: daf-1 / 176829
• WormBaseID: WBGene00000897
• Length: 669
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 177/562 - (31%)
• Similarity: 264/562 - (46%)
• Gaps: 109/562 - (19%)

Human    24 EKPKVN-PKLYMCVCE--------------GLSCGNEDHCEGQQCFSSLSINDGFHVYQK----- 68
            |..||| .:|::|.|.              |:...||   ..:..:.:....|| ..||.
 Worm    44 EVTKVNFTRLHLCHCSREVGCNARTTGWVPGIEFLNE---TDRSFYENTCYTDG-SCYQSARPSP 104

Human    69 -----GCF---------QVYEQGKMTCKTPPSPGQAVE--CC-QGDWCNRNITAQLPTKGKSFPG 116
                 ||.         :.::.....|........|..  || :|::|.......|.      ||
 Worm   105 EISHFGCMDEKSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGNFCANETIIHLA------PG 163

Human   117 TQNFHLEVGLIILSVV-FAVCLLACLLGVAL---RK-----------FKRRNQERLNPRD----- 161
            .|.....:.|.||::: |.|     |||:|:   ||           ||.:..:.|...:
 Worm   164 PQQSSTWLILTILALLTFIV-----LLGIAIFLTRKSWEAKFDWYIRFKPKPGDPLRETENNVPM 223

Human   162 -----------VEYGTIE---GLITTNVGDS--------TLADLLD-HSCTSGSGSGLPFLVQRT 203
                       .|...||   ..::|:.|:|        .:.|:|| ...|||||.|...|.:.|
 Worm   224 VTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLEETSGSGMGPTTLHKLT 288

Human   204 VARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIAS 268
            :..||.|...||.||:|.|.||.::||.||||:|::.||.::.:|||::.|.||||.|:|.:|.|
 Worm   289 IGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGS 353

Human   269 DMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ--GKPA 331
            |.......|:|||:|.||..|||:|:|...|::..:...::.|.|||||.||.:|.|::  .|||
 Worm   354 DRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPA 418

Human   332 IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQ-STNQLDVGNNPRVGTKRYMAPEVLDETIQVDC 395
            :||||:|||||:||.:..|.|.||||::...: :.:.:....|.:.||.||:|||:|:.|:|...
 Worm   419 MAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQFTV 483

Human   396 FDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKP-------PFYDVVPNDPSFEDMRKVVCVDQQ 453
            |:||:..|:::|.||:||...|....    |..|       |:.:....||....|..|||..:.
 Worm   484 FESYQCADVYSFSLVMWETLCRCEDG----DVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRL 544

Human   454 RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL 495
            ||.....|...|.:..:.:::|.||..|||||.|:...:|.:
 Worm   545 RPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	Activin_recp	37..103	CDD:395845	16/101 (16%)
		TGF_beta_GS	179..206	CDD:400699	11/27 (41%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	121/304 (40%)
daf-1	NP_001023159.1	GS	265..293	CDD:197743	11/27 (41%)
		Pkinase_Tyr	293..576	CDD:285015	115/286 (40%)
		STKc_TGFbR_I	297..589	CDD:270958	117/294 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451964
Domainoid	1	1.000	236	1.000	Domainoid score	I1477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I2302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm16226
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.890