Protein Alignment ACVR1 and sma-6

DIOPT Version :9

• Sequence 1: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_495271.1
• Gene: sma-6 / 174044
• WormBaseID: WBGene00004860
• Length: 636
• Species: Caenorhabditis elegans
• Alignment Length: 577
• Identity: 190/577 - (32%)
• Similarity: 282/577 - (48%)
• Gaps: 140/577 - (24%)

Human    35 CVC--EGLSCGNEDHC---EGQQCFSSLSINDGFHVYQK-----------GCFQVYEQGK----M 79
            |.|  :...|||...|   :|..|:.::.     .||.|           || ...|:|.    :
 Worm    68 CYCNYDQSICGNNMTCVKQDGAACYHAVE-----EVYNKAEKRMETLHKWGC-ATLERGSGASHL 126

Human    80 TCKT----PPSPGQAVECC-QGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL------------- 126
            ||.:    ..|| :::.|| :|::||:|:   :|      |...:.|.|..|
 Worm   127 TCNSWRAAHHSP-KSIGCCYEGNYCNKNL---IP------PAYVHHHKEKALQEKTDNPEDYDSP 181

Human   127 ----------------IILSVVFAV--CLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITT 173
                            .::| ||||  |:..|     :.:.:.:::.|...:.|...|
 Worm   182 LENMTRGGKMFIMVFATVMS-VFAVIGCIYLC-----ITRAEEKSKARARAKTVSLKT------- 233

Human   174 NVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFS 238
               :||..:.......||||||...|:||||.:.:|:::.:|:||||||.:..::|..||||.|.
 Worm   234 ---ESTYMESKSMLEDSGSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFY 295

Human   239 SRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSS-TQLWLITHYHEMGSLYDYL-QLTTLD 301
            :.||.||..|.::|.|.|:.|||||.|:|:|:.|...| |::.|||.|||:|||.||| :..||.
 Worm   296 TTDEDSWKNERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLT 360

Human   302 TVSCLRIVLSIASGLAHLHIEIFGTQG--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS 364
            |...||::.|...|:.|||..:.||..  ||.|||||:|||||:||:...|||||||||:.: |:
 Worm   361 TDEALRLIHSCICGIEHLHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRY-QN 424

Human   365 TNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRM----------- 418
            ...|....|.:||||||||||::...:....|..:|..||::..||:||||.|:
 Worm   425 DKILPEKFNVQVGTKRYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTV 489

Human   419 --------VSNGIVE----------------------------DYKPPFYDVVPNDPSFEDMRKV 447
                    .|:||.|                            .:.|||..:|.|||:|::|..|
 Worm   490 DETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDV 554

Human   448 VCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDK 504
            :||.:.||.....|.:.|.|..|:|||::.|:..|..|.:||::||.:.::..:.|:
 Worm   555 ICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKNPDR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	Activin_recp	37..103	CDD:395845	23/90 (26%)
		TGF_beta_GS	179..206	CDD:400699	12/26 (46%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	139/347 (40%)
sma-6	NP_495271.1	Activin_recp	66..157	CDD:279413	26/104 (25%)
		GS	238..265	CDD:197743	11/26 (42%)
		S_TKc	266..>473	CDD:214567	99/207 (48%)
		STKc_TGFbR_I	269..605	CDD:270958	135/336 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm15006
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750