Protein Alignment CDKL2 and CMK2

DIOPT Version :9

• Sequence 1: NP_001317653.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_014626.1
• Gene: CMK2 / 854144
• SGDID: S000005376
• Length: 447
• Species: Saccharomyces cerevisiae
• Alignment Length: 441
• Identity: 104/441 - (23%)
• Similarity: 177/441 - (40%)
• Gaps: 110/441 - (24%)

Human    10 VGEGSYGMVMKCRNKDTGRIVAI----KKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVC 70
            :|.||:|:|.:.|...|...|||    ||.|:.::.::  ::...|:.:|::|.|.|:|:..:..
Yeast    53 LGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQL--QMLYEELSILQKLSHPNIVSFKDWF 115

Human    71 KKKKRWYLVFEFVDHTILDDLELFPNGLDYQV-VQKYLFQIINGIGFCHSHNIIHRDIKPENILV 134
            :.|.::|:|.:......|.| .:...|...:| ..:.:.||:..:.:.||.|::|||:||||:|.
Yeast   116 ESKDKFYIVTQLATGGELFD-RILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLY 179

Human   135 ---SQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF 196
               |::..:.:.|||.|:.|....::......:..|.|||:|..| .:||..|:|:||.:...:.
Yeast   180 VDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQD-GHGKPCDIWSIGVITYTLL 243

Human   197 MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVI 261
            .|...|..:|                            ..|........|.|:....|....:.|
Yeast   244 CGYSPFIAES----------------------------VEGFMEECTASRYPVTFHMPYWDNISI 280

Human   262 DLAK---KCLHIDPDKRPFCAELLHHDFFQ-------------MDGFAERFSQELQLKVQ----- 305
            |:.:   |.|.::|..||...|||...:..             ..||:.|  ::|:..::
Yeast   281 DVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDVKKGFSLR--KKLRDAIEIVKLN 343

Human   306 ---KDARNV-SLSKKSQN----------------------RKKEKEKDDSLVEER--------KT 336
               |..||: ||.....|                      |.:.::|...|.||:        |.
Yeast   344 NRIKRLRNMYSLGDDGDNDIEENSLNESLLDGVTHSLDDLRLQSQKKGGELTEEQMKLKSALTKD 408

Human   337 LVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNK 387
            ..||...|..|.| :|:  :.|.:.|..|          ..|||.|.|.::
Yeast   409 AFVQIVKAATKNK-HKV--LAGEEEDDSK----------KTLHDDRESKSE 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	NP_001317653.1	STKc_CDKL2_3	2..287	CDD:270836	74/287 (26%)
		S_TKc	4..287	CDD:214567	74/287 (26%)
		[NKR]KIAxRE	45..51		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..384		5/20 (25%)
CMK2	NP_014626.1	STKc_CAMK	46..308	CDD:270687	74/286 (26%)
		S_TKc	47..309	CDD:214567	74/287 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910