| Sequence 1: | XP_006713873.1 | Gene: | KALRN / 8997 | HGNCID: | 4814 | Length: | 2988 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261317.1 | Gene: | zormin / 2769001 | FlyBaseID: | FBgn0052311 | Length: | 3664 | Species: | Drosophila melanogaster |
| Alignment Length: | 2606 | Identity: | 471/2606 - (18%) |
|---|---|---|---|
| Similarity: | 883/2606 - (33%) | Gaps: | 785/2606 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 547 VQQVLDWIENHGEAFLS------KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 605
Human 606 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDV 670
Human 671 CADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPH 735
Human 736 SSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND 800
Human 801 FNT-----EDLTLAEQRLQRHTERK---LAMNNMTFEVIQQGQDLHQ--YITEVQA--------S 847
Human 848 GIELICEKDIDLAAQVQELL----EFLHEKQH--------ELEL--------------------- 879
Human 880 -------------------------------------------------NAEQTHKRLEQCLQ-- 893
Human 894 LRHLQAEVKQVLGWIR-NGESMLNASLVNASSLSEAEQ-LQREHEQFQ----------LAIESLF 946
Human 947 HATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHW---QQLMLKMEDRLKLVNASV 1008
Human 1009 AFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARR 1073
Human 1074 NAEVFLKYIHRNNVSMPSVASH--TRGPEQQVKAILSELLQRENRV---LHFWTLKKRRLDQCQQ 1133
Human 1134 YVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQ----TKEKVKLLI 1194
Human 1195 QLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDL-ELDIIPAS 1258
Human 1259 LSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYV---RDLHECLETYLWEMTSGVEEI 1320
Human 1321 PPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSN 1385
Human 1386 QLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLS 1450
Human 1451 VPKKANDAMHVSMLEGFDENLDVQGELILQ------DAFQVWDPKSLIRKGRERHLFLFEISLVF 1509
Human 1510 SKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWI 1574
Human 1575 KN------IREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG------VEDIDSQGDGSSQP 1627
Human 1628 DTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRT 1692
Human 1693 TERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIH 1757
Human 1758 SSPGPKRSTNTLKKWLTSPVRRLNSGKADG--NIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSA 1820
Human 1821 DEKSKKGWGEDE--------PDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADL 1877
Human 1878 VNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQT 1942
Human 1943 EKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCI-QEQDRL 2006
Human 2007 AQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDF---LIKPIQRITKY 2068
Human 2069 QLLLKDFLRYSEKA---------GLECSDIEKAVELMCLVPKRCNDMMNLGRL---QGFEGTLTA 2121
Human 2122 QG------------KLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFK 2174
Human 2175 RSIKMNYLVLE--ENVDNDPCKFALMN--RETSERVVLQAANADIQQAWVQDINQVLETQ-RDFL 2234
Human 2235 NALQSPIEYQRKERSTAVMRSQPARLPQASP---------------RPYSS--------VPAGSE 2276
Human 2277 KPPKGSSYNPPLP----PLK-ISTSNGSP--------------GFEYHQPGDKFEASKQNDLGGC 2322
Human 2323 NGTSSMAVIKDYYALKENEICV----SQGEV-----VQVLAVNQQNMCLVYQPAS---------- 2368
Human 2369 -DHSPAAEGWVPGSILAPLTKATAAE-SSDGSIKKSCSW----HTLRMRKRAEVENTGK------ 2421
Human 2422 --NEATGPRKPKDILGNKVSVKETNSSEESEC-------------DDLDPNTSMEILNPNFIQEV 2471
Human 2472 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2536
Human 2537 ICNLMPQDS-GIYTCIATNDHGTTSTSATVKVQ--GVPAAPN-RPIAQERSCTS--VILRWLPPS 2595
Human 2596 STGNCTISGY-----TVEYREEGSQIWQ------QSVASTLDTYLVIE-----DLSPGCPYQFRV 2644
Human 2645 S------ASNPWGISLPSEPSEFVR--LPEY---------DAAAD-----------GATISWKEN 2681
Human 2682 ----FDSAYT-----------ELNEIG---RGRFSI-VKKCIHKAT-RKDVAVK----------- 2715
Human 2716 FVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESP---------------TSYILILE---LM 2762
Human 2763 DDGRLL 2768 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| KALRN | XP_006713873.1 | SEC14 | 41..179 | CDD:214706 | |
| SPEC | 192..412 | CDD:238103 | |||
| SPEC | 313..538 | CDD:238103 | |||
| SPEC | 539..768 | CDD:238103 | 49/226 (22%) | ||
| SPEC | 893..1131 | CDD:238103 | 56/259 (22%) | ||
| SPEC | <1101..1240 | CDD:295325 | 22/145 (15%) | ||
| RhoGEF | 1286..1456 | CDD:238091 | 29/172 (17%) | ||
| PH1_Kalirin_Trio_like | 1463..1585 | CDD:270060 | 22/133 (17%) | ||
| PH | 1496..1581 | CDD:278594 | 14/90 (16%) | ||
| SH3_Kalirin_1 | 1651..1710 | CDD:212786 | 9/58 (16%) | ||
| SH3-RhoG_link | 1708..1934 | CDD:293215 | 32/235 (14%) | ||
| RhoGEF | 1935..2105 | CDD:279015 | 39/182 (21%) | ||
| PH2_Kalirin_Trio_p63RhoGEF | 2109..2243 | CDD:270061 | 29/153 (19%) | ||
| PH | 2142..2228 | CDD:278594 | 17/89 (19%) | ||
| SH3_Kalirin_2 | 2327..2385 | CDD:212787 | 15/77 (19%) | ||
| I-set | 2473..2567 | CDD:254352 | 24/94 (26%) | ||
| Ig | 2490..2564 | CDD:143165 | 19/74 (26%) | ||
| FN3 | 2571..2662 | CDD:238020 | 19/115 (17%) | ||
| S_TKc | 2686..2940 | CDD:214567 | 26/128 (20%) | ||
| STKc_Kalirin_C | 2692..2939 | CDD:271017 | 23/111 (21%) | ||
| zormin | NP_001261317.1 | SPEC | 126..332 | CDD:238103 | 47/210 (22%) |
| SPEC | <504..641 | CDD:295325 | 33/159 (21%) | ||
| COG1340 | 960..1298 | CDD:224259 | 72/454 (16%) | ||
| RILP-like | <1190..1315 | CDD:304877 | 17/131 (13%) | ||
| MAP7 | 1233..1365 | CDD:283355 | 23/150 (15%) | ||
| I-set | 1390..1479 | CDD:254352 | 20/110 (18%) | ||
| IGc2 | 1403..1469 | CDD:197706 | 18/87 (21%) | ||
| I-set | 1491..1580 | CDD:254352 | 17/97 (18%) | ||
| IGc2 | 1504..1570 | CDD:197706 | 13/71 (18%) | ||
| I-set | 1589..1675 | CDD:254352 | 21/101 (21%) | ||
| Ig | 1605..1675 | CDD:299845 | 18/85 (21%) | ||
| I-set | 1702..1786 | CDD:254352 | 17/85 (20%) | ||
| Ig | 1713..1786 | CDD:299845 | 12/74 (16%) | ||
| I-set | 1811..1902 | CDD:254352 | 17/97 (18%) | ||
| Ig | 1828..1892 | CDD:143165 | 12/69 (17%) | ||
| I-set | 1927..2015 | CDD:254352 | 24/94 (26%) | ||
| IGc2 | 1940..2005 | CDD:197706 | 18/71 (25%) | ||
| I-set | 2142..2231 | CDD:254352 | 16/88 (18%) | ||
| Ig | 2158..2231 | CDD:299845 | 13/72 (18%) | ||
| I-set | 2238..2325 | CDD:254352 | 16/77 (21%) | ||
| Ig | 2254..2324 | CDD:299845 | 13/61 (21%) | ||
| I-set | 3566..3655 | CDD:254352 | |||
| Ig | 3583..3650 | CDD:143165 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG4240 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||