DRSC/TRiP Functional Genomics Resources

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Protein Alignment KALRN and zormin

DIOPT Version :10

Sequence 1:XP_006713873.1 Gene:KALRN / 8997 HGNCID:4814 Length:2988 Species:Homo sapiens
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:2606 Identity:471/2606 - (18%)
Similarity:883/2606 - (33%) Gaps:785/2606 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   547 VQQVLDWIENHGEAFLS------KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 605
            :|.|:..:::..:.::.      |.|.:|::|..:..:|:.||:.....|:.....|:.::.|::
  Fly   107 IQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADK 171

Human   606 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDV 670
            |..:.....|.:...|..|.:..||.:..::.|:.||.:...||....:.:..|:.|:....|.:
  Fly   172 LLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRKMDQLELACEETL 236

Human   671 CADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPH 735
            ....|..|||.:.:|:|.:...|...:..:|:|.:|:.||...     |..|..|:...:.|...
  Fly   237 HPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQLEEL-----EKLETLDTRPEHIKRDA 296

Human   736 SSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND 800
            :.::..::..|:.|.|.:..:|..:..|||:::..|.|.:..:..:::.|.|.....:|      
  Fly   297 TRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAALQQARMEL------ 355

Human   801 FNT-----EDLTLAEQRLQRHTERK---LAMNNMTFEVIQQGQDLHQ--YITEVQA--------S 847
             ||     |....|.:.|.::.|.|   |.:.:...::.:..:.:..  :.||..|        |
  Fly   356 -NTMYSLGECEHTANEMLTKYREWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLS 419

Human   848 GIELICEKDIDLAAQVQELL----EFLHEKQH--------ELEL--------------------- 879
            |    |.:.:||..|.:..|    ||..:.:|        ||||                     
  Fly   420 G----CTEHLDLVDQREHWLHQSREFFAKAEHTVSVLEKLELELTSVKLPPHSPESYAMFSKVDR 480

Human   880 -------------------------------------------------NAEQTHKRLEQCLQ-- 893
                                                             |:.:..:::::.|.  
  Fly   481 DVRNFTEEPLRLGYGILDEVGRTQPETQGVKRVLDELENRKVYIQGICANSSEDQQKVQRALSEF 545

Human   894 LRHLQAEVKQVLGWIR-NGESMLNASLVNASSLSEAEQ-LQREHEQFQ----------LAIESLF 946
            |.|    ..::|.|:| :|:..|..|:....:|.:|:| |.:.||..|          |.:||: 
  Fly   546 LNH----HNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESI- 605

Human   947 HATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHW---QQLMLKMEDRLKLVNASV 1008
                  |.|..:|..|::         ||.|:..|...|   ||   :.|:||..|.:.|:   :
  Fly   606 ------KVHLESLSPQER---------YDVDSKAESLHK---HWIELKDLVLKRVDYVSLL---I 649

Human  1009 AFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARR 1073
            .|::.:.::.|.|::|:::.::..|                         |.|..||:|......
  Fly   650 DFFELANELSSQLDNLQRQLQQTPD-------------------------EHKLQFLQATWTGIA 689

Human  1074 NAEVFLKYIHRNNVSMPSVASH--TRGPEQQVKAILSELLQRENRV---LHFWTLKKRRLDQCQQ 1133
            :....||...:..:::..|..:  |:...|.|:..|::..:|:..|   |..||..         
  Fly   690 STFGELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTS--------- 745

Human  1134 YVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQ----TKEKVKLLI 1194
             :..:|..:..|:.:....|      .:..::|:...:|...:....|.:||    |:||:..:|
  Fly   746 -IAEKREVEYLLEKVMSDNE------ETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVI 803

Human  1195 QLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDL-ELDIIPAS 1258
            |                            |......:.:..::..||:.|:|...| :::.:..:
  Fly   804 Q----------------------------DIERAQDEIQQRIQTTLGIQTKDQPSLAKIEQVINN 840

Human  1259 LSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYV---RDLHECLETYLWEMTSGVEEI 1320
            |...:.||....::...           ::..::|..:..|   |::.:.......|..||.:. 
  Fly   841 LRMLKAKLDGIKYDYRT-----------LVESVIQFLENIVQLRREIDDYFARQQKEPASGADR- 893

Human  1321 PPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSN 1385
                                     .:.|.||:..      .|.    |||:..:|..:...|..
  Fly   894 -------------------------SIAEHEKFRD------QCM----DKFRSLITQSELLIDRV 923

Human  1386 QLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLS 1450
            : :||..|            |..|.:      .||.|   ||:.|....|.........||.:..
  Fly   924 R-VLEPPG------------AREIDT------DRILK---LLENLRLHFESNSSARMSTLERLEK 966

Human  1451 VPKKANDAMHVSMLEGFDENLDVQGELILQ------DAFQVWDPKSLIRKGRERHLFLFEISLVF 1509
            :.:..:|      ||..|.:||...:.:.:      |:.......||..:..||.:   |.|:  
  Fly   967 IEQFRSD------LEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTI---ECSM-- 1020

Human  1510 SKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWI 1574
            .:::|.:....::           |.|.|              |.....|.:.|.:...::|.:|
  Fly  1021 PRQLKSTRHQRRW-----------GQTAH--------------TIELLEKRIEKFTESTSQQLFI 1060

Human  1575 KN------IREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG------VEDIDSQGDGSSQP 1627
            .|      :::.:::        |.|..|..|...||:..|....      ||.||      ::.
  Fly  1061 TNPESERYVKDELRK--------LNEKWQSFKDQVKQKRKSLNQATDFFEVVEKID------AEY 1111

Human  1628 DTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRT 1692
            ..||....:..|.|.            .|:|         :::.|..|..:|.          ..
  Fly  1112 REISYFYTSVSNKVP------------YLRD---------SVEAGNLVNDIEN----------YV 1145

Human  1693 TERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIH 1757
            |.|...|...:.|::.| :|..:.|.     .|..|.                       :|...
  Fly  1146 TSREAALRSKLDSASQC-AHDMNKVS-----SLYNDV-----------------------MNIFQ 1181

Human  1758 SSPGPKRSTNTLKKWLTSPVRRLNSGKADG--NIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSA 1820
            |....|...|.:::.|....|:....:.|.  ..:::|.:::......|...:.......:..:|
  Fly  1182 SFIKLKMDINVVQERLKQEQRQKEQRERDARDQAEREKAIKEAEAKERLHREEQSRLENQRQQAA 1246

Human  1821 DEKSKKGWGEDE--------PDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADL 1877
            .|::::.....|        .:||:.      ::......|:::::.. .|||:....:.:..|:
  Fly  1247 IEQAQRELAARELALREQAVREEEAR------LQAIREQATREQLARE-QAAREEELRIQSLRDI 1304

Human  1878 VNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQT 1942
            ....|::....:..|.:..|...::.....||..:        :.|::|:..|..:..|    ||
  Fly  1305 ARREEEVRLQNIRDEETRIRREEEERIRRENESRS--------KREEEARIQREEITRL----QT 1357

Human  1943 EKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCI-QEQDRL 2006
            .:|.|....||.|...|.|:...:..::|               :....|...|:..: :|.|| 
  Fly  1358 LRDQVDQQRIVTENIRKDIQVNSIFTELR---------------YASPLFTRPLKDAVSREGDR- 1406

Human  2007 AQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDF---LIKPIQRITKY 2068
                         :|:.|:       :....:...|..|..|:.: |.||:   ..|.|.|:...
  Fly  1407 -------------FVFECE-------VTGTPEPAVEWFKDGISIQ-TNSDYKTTFDKGICRLVIE 1450

Human  2069 QLLLKDFLRYSEKA---------GLECSDIEKAVELMCLVPKRCNDMMNLGRL---QGFEGTLTA 2121
            :....|..|:|.:|         ....|..|.|.|:. |||.|....:..|:.   ..|:.....
  Fly  1451 ETFAADSARFSCRASNLVGTCDTNATLSVRENAAEVQ-LVPPRILRFLQSGKATEGSSFQFACVV 1514

Human  2122 QG------------KLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFK 2174
            .|            |.:.....|||..:.| ::..|...|||.:..|...     .:..|..:..
  Fly  1515 AGVPLPTVQWFKNDKCIDDSPDYVISYNNG-EATLKFEEVFLEDDAVYTC-----SASNPAGIEH 1573

Human  2175 RSIKMNYLVLE--ENVDNDPCKFALMN--RETSERVVLQAANADIQQAWVQDINQVLETQ-RDFL 2234
            .|..   |::|  |..:....|..|.|  ....:::.|:|....|.:..|..::.....| ||  
  Fly  1574 CSAS---LIVEPLEPTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQPRD-- 1633

Human  2235 NALQSPIEYQRKERSTAVMRSQPARLPQASP---------------RPYSS--------VPAGSE 2276
                |..||   .|.|.:       :|||.|               ..|:|        :|..:.
  Fly  1634 ----SKYEY---GRVTLI-------IPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETS 1684

Human  2277 KPPKGSSYNPPLP----PLK-ISTSNGSP--------------GFEYHQPGDKFEASKQNDLGGC 2322
            .....|...|..|    ||| :|...|.|              ...||......|::....|  .
  Fly  1685 DSEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLL--F 1747

Human  2323 NGTSSMAVIKDYYALKENEICV----SQGEV-----VQVLAVNQQNMCLVYQPAS---------- 2368
            .|.....:|::.|........|    |.||.     ::|..:||.      :||:          
  Fly  1748 QGDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQA------EPATRAQAERQSLP 1806

Human  2369 -DHSPAAEGWVPGSILAPLTKATAAE-SSDGSIKKSCSW----HTLRMRKRAEVENTGK------ 2421
             |..|..|..: ..:||...:....| .:.|....:..|    ..|::.:|...::..:      
  Fly  1807 KDSQPKFERLL-SDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKL 1870

Human  2422 --NEATGPRKPKDILGNKVSVKETNSSEESEC-------------DDLDPNTSMEILNPNFIQEV 2471
              |..:|..|      ...:||.||.:.:::|             :.....:|:||:.    :..
  Fly  1871 ILNNVSGDDK------GVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIE----RHQ 1925

Human  2472 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2536
            .|||.....|....:.:.:..:|.|.|:|.|.:.|...||.:     ....:.||:  |||..:.
  Fly  1926 CPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFNDQPV-----HGHNFLVST--SGERQVL 1983

Human  2537 ICNLMPQDS-GIYTCIATNDHGTTSTSATVKVQ--GVPAAPN-RPIAQERSCTS--VILRWLPPS 2595
            ....:..|: |..:|:|.|:.|..:..|.:.::  |:||:.: :.::||.:..|  |.::....:
  Fly  1984 TIQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFT 2048

Human  2596 STGNCTISGY-----TVEYREEGSQIWQ------QSVASTLDTYLVIE-----DLSPGCPYQFRV 2644
            :|....::.|     ..|.....:.|.|      |.....::::...|     ::|.....|...
  Fly  2049 TTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSF 2113

Human  2645 S------ASNPWGISLPSEPSEFVR--LPEY---------DAAAD-----------GATISWKEN 2681
            |      |:....:::|..|:...|  .|.:         |..||           ...|..::|
  Fly  2114 SFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKN 2178

Human  2682 ----FDSAYT-----------ELNEIG---RGRFSI-VKKCIHKAT-RKDVAVK----------- 2715
                |:.|:|           ||.::|   .||::: ....:.::| ..|:.||           
  Fly  2179 GGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFPPVFGRR 2243

Human  2716 FVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESP---------------TSYILILE---LM 2762
            ..::..||.|:...|.. :..|..|....|.|  :.|               .||.||:|   ..
  Fly  2244 LQAQVSKKGEKLTMEVE-VTGLPEPTVTWLKD--DKPLKDAGISEHRLLAQGNSYRLIIEKAQTT 2305

Human  2763 DDGRLL 2768
            |.|:.:
  Fly  2306 DSGKYM 2311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KALRNXP_006713873.1 SEC14 41..179 CDD:214706
SPEC 192..412 CDD:238103
SPEC 313..538 CDD:238103
SPEC 539..768 CDD:238103 49/226 (22%)
SPEC 893..1131 CDD:238103 56/259 (22%)
SPEC 1137..1237 CDD:197544 14/103 (14%)
RhoGEF 1286..1456 CDD:238091 29/172 (17%)
PH1_Kalirin_Trio_like 1463..1585 CDD:270060 22/133 (17%)
SH3_Kalirin_1 1651..1710 CDD:212786 9/58 (16%)
SH3-RhoG_link 1708..1934 CDD:465196 32/235 (14%)
RhoGEF 1935..2104 CDD:459876 39/181 (22%)
PH2_Kalirin_Trio_p63RhoGEF 2109..2243 CDD:270061 29/153 (19%)
SH3_Kalirin_2 2327..2385 CDD:212787 15/77 (19%)
I-set 2473..2567 CDD:400151 24/94 (26%)
Ig strand B 2490..2494 CDD:409570 0/3 (0%)
Ig strand C 2503..2507 CDD:409570 0/3 (0%)
Ig strand E 2533..2537 CDD:409570 0/3 (0%)
Ig strand F 2547..2552 CDD:409570 1/4 (25%)
Ig strand G 2560..2563 CDD:409570 0/2 (0%)
FN3 2571..2662 CDD:238020 19/115 (17%)
STKc_Kalirin_C 2692..2939 CDD:271017 23/111 (21%)
zorminNP_001261317.1 SPEC 126..332 CDD:238103 47/210 (22%)
SPEC <504..641 CDD:413338 33/159 (21%)
SMC_prok_B 654..>1389 CDD:274008 162/1016 (16%)
Smc <1192..>1377 CDD:440809 32/203 (16%)
I-set 1390..1479 CDD:400151 20/110 (18%)
Ig strand B 1407..1411 CDD:409564 1/3 (33%)
Ig strand C 1420..1424 CDD:409564 1/3 (33%)
Ig strand E 1445..1449 CDD:409564 1/3 (33%)
Ig strand F 1459..1464 CDD:409564 2/4 (50%)
Ig strand G 1472..1475 CDD:409564 0/2 (0%)
I-set 1491..1580 CDD:400151 17/97 (18%)
Ig strand B 1508..1512 CDD:409353 1/3 (33%)
Ig strand C 1521..1525 CDD:409353 0/3 (0%)
Ig strand E 1546..1550 CDD:409353 0/3 (0%)
Ig strand F 1560..1565 CDD:409353 1/9 (11%)
Ig strand G 1573..1576 CDD:409353 0/2 (0%)
I-set 1589..1675 CDD:400151 21/101 (21%)
Ig strand B 1606..1610 CDD:409353 1/3 (33%)
Ig strand C 1619..1623 CDD:409353 1/3 (33%)
Ig strand E 1641..1645 CDD:409353 1/10 (10%)
Ig strand F 1655..1660 CDD:409353 0/4 (0%)
Ig strand G 1668..1671 CDD:409353 1/2 (50%)
I-set 1702..1786 CDD:400151 17/85 (20%)
Ig strand B 1714..1718 CDD:409353 0/3 (0%)
Ig strand C 1727..1731 CDD:409353 0/3 (0%)
Ig strand E 1752..1756 CDD:409353 0/3 (0%)
Ig strand F 1766..1771 CDD:409353 1/4 (25%)
Ig strand G 1779..1782 CDD:409353 0/2 (0%)
I-set 1811..1902 CDD:400151 17/97 (18%)
Ig strand B 1828..1832 CDD:409353 0/3 (0%)
Ig strand C 1841..1845 CDD:409353 0/3 (0%)
Ig strand E 1868..1872 CDD:409353 0/3 (0%)
Ig strand F 1882..1887 CDD:409353 1/4 (25%)
I-set 1927..2015 CDD:400151 24/94 (26%)
Ig strand B 1944..1948 CDD:409353 0/3 (0%)
Ig strand C 1957..1961 CDD:409353 0/3 (0%)
Ig strand E 1981..1985 CDD:409353 0/3 (0%)
Ig strand F 1995..2000 CDD:409353 1/4 (25%)
Ig strand G 2008..2011 CDD:409353 0/2 (0%)
Ig 2142..2231 CDD:472250 16/88 (18%)
Ig strand B 2159..2163 CDD:409353 0/3 (0%)
Ig strand C 2172..2176 CDD:409353 1/3 (33%)
Ig strand E 2197..2201 CDD:409353 0/3 (0%)
Ig strand F 2211..2216 CDD:409353 1/4 (25%)
Ig strand G 2224..2227 CDD:409353 1/2 (50%)
I-set 2238..2325 CDD:400151 16/77 (21%)
Ig strand B 2255..2259 CDD:409353 0/3 (0%)
Ig strand C 2268..2272 CDD:409353 0/3 (0%)
Ig strand F 2309..2314 CDD:409353 0/3 (0%)
PHA03247 <2593..2893 CDD:223021
I-set 3566..3655 CDD:400151
Ig strand B 3583..3587 CDD:409353
Ig strand C 3596..3600 CDD:409353
Ig strand E 3621..3625 CDD:409353
Ig strand F 3635..3640 CDD:409353
Ig strand G 3648..3651 CDD:409353
Blue background indicates that the domain is not in the aligned region.

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