Protein Alignment RHOT2 and rhot2

DIOPT Version :10

• Sequence 1: NP_001339204.1
• Gene: RHOT2 / 89941
• HGNCID: 21169
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_001032768.1
• Gene: rhot2 / 557574
• ZFINID: ZDB-GENE-051120-96
• Length: 617
• Species: Danio rerio
• Alignment Length: 626
• Identity: 409/626 - (65%)
• Similarity: 479/626 - (76%)
• Gaps: 28/626 - (4%)

Human     1 MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTD 65
            |:||||||||||.:|||||||:|||||||||:||.|||||||||||||||||||||||||.||||
Zfish     1 MKRDVRILLLGEPKVGKTSLIMSLVGEEFPEQVPLRAEEITIPADVTPEKVPTHIVDYSENEQTD 65

Human    66 EELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEA 130
            |.|||||.|||||||||||::|.||:|||||||||||||..:|.::||||||||||||||||||.
Zfish    66 EVLREEIVKANVVCVVYDVTQEETIDKIRTKWIPLVNGGAEKGSKIPIILVGNKSDLRSGSSMET 130

Human   131 VLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRL 195
            :||||:||.|||||||||||||:||||||||||||||||||||||||.|||:..|.:||:|||.:
Zfish   131 ILPIMNQFSEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEDKQLKAQCVRALSRIFSI 195

Human   196 SDQDLDQALSDEELNAFQQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFI 260
            ||||.|..|||.|||.| ||.|||:||||||||||||||.:|.:.||:::.|||:||||||||||
Zfish   196 SDQDNDHILSDAELNCF-QKLCFGNPLAPQALEDVKTVVWKNTSDGVQDNGLTLNGFLFLNTLFI 259

Human   261 QRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGAL 325
            |||||||||||||:|||.|.||||.|||.|::.|..||:|||||||:||:.::|||:|:|:|.||
Zfish   260 QRGRHETTWTILRKFGYDDTLELTDDYLYPVLRVSVGCTTELNHLGHQFLLKLFEKYDEDKDSAL 324

Human   326 SPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPL--------HGYLCQWTLVTYLDVRSCLGHLG 382
            ||.||::||||.|..||.       .|....:||        |||||||.|:.||||..||.|||
Zfish   325 SPAELKNLFSVLPYMPWS-------STVYSNIPLTDDCYISQHGYLCQWMLLAYLDVHRCLEHLG 382

Human   383 YLGYPTLCEQD-QAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQD 446
            |||||.|.||: |..||||||||.||.:..||||:|.||||:|.||.||:.||:|||.|.....|
Zfish   383 YLGYPILMEQECQTSAITVTREKALDLDNRQTQRTVFLCKVIGPRGTGKTDFLRAFLQRSTERSD 447

Human   447 TREQPPG----YAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCAS 507
               :.||    |||:||.:..|:|||||.||..:.....:.||.|||||||:|.|||.||.:|||
Zfish   448 ---RDPGAPSIYAINTVSIANQDKYLILEEVDVETEFLKAADAACDVACLMYDVSDPDSFNYCAS 509

Human   508 VYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLA 572
            :||.||||...||:.:.|||||.|.....|.||:|||.|||||:|:.|| |......|.|:::|.
Zfish   510 IYKQHYMDSGIPCVVLGSKADLVEVKQHHGMSPSEFCYKHRLPSPLHFS-ALLTHTHTHIYSKLT 573

Human   573 TMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYR 613
            ..|.:|||..:::..:|||||..|   ||.:||:|.|:|||
Zfish   574 WAAMYPHLNGSDMSSTSFWLRVTL---GATIAAMLGFALYR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT2	NP_001339204.1	Miro1	3..169	CDD:206680	142/165 (86%)
		EF_assoc_2	221..304	CDD:462444	61/82 (74%)
		EF_assoc_1	342..409	CDD:462443	40/75 (53%)
		Miro2	414..590	CDD:206679	88/179 (49%)
rhot2	NP_001032768.1	Miro1	3..169	CDD:206680	142/165 (86%)
		EF_assoc_2	220..303	CDD:462444	61/82 (74%)
		EF_assoc_1	341..409	CDD:462443	39/74 (53%)
		Miro2	415..591	CDD:206679	88/179 (49%)