Protein Alignment RHOT2 and rhot2

DIOPT Version :10

• Sequence 1: NP_001339204.1
• Gene: RHOT2 / 89941
• HGNCID: 21169
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_001006725.1
• Gene: rhot2 / 448378
• XenbaseID: XB-GENE-489616
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 439/622 - (70%)
• Similarity: 500/622 - (80%)
• Gaps: 9/622 - (1%)

Human     1 MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTD 65
            |:|||||||||||||||||||::|||||||:|||.||||||||||||||::||||||||..|||:
 Frog     1 MKRDVRILLLGEAQVGKTSLIMALVGEEFPDEVPSRAEEITIPADVTPERIPTHIVDYSGVEQTE 65

Human    66 EELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEA 130
            :||||||.|||||||||||::..|||||.:||||:|||...:..|:|||||||||||:.|||||:
 Frog    66 DELREEIAKANVVCVVYDVTDLETIEKIGSKWIPMVNGNAERNSRLPIILVGNKSDLQCGSSMES 130

Human   131 VLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRL 195
            :||||:||.|||||||||||||:||||:|||||||||||||||||||.|||||.|.:||||||.:
 Frog   131 ILPIMNQFSEIETCVECSAKNLKNISEVFYYAQKAVLHPTAPLYDPEEKQLRPQCKKALTRIFTI 195

Human   196 SDQDLDQALSDEELNAFQQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFI 260
            |:||.:|.|||||||.||| ||||:|||||||||||.||.:|.|.|||::.|||:||||||||||
 Frog   196 SEQDNNQILSDEELNFFQQ-SCFGNPLAPQALEDVKMVVKKNTADGVRDNGLTLNGFLFLNTLFI 259

Human   261 QRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGAL 325
            |||||||||||||||||.||||||.|||.|.:.:|...||||||.||||:|:.|||||.|.||||
 Frog   260 QRGRHETTWTILRRFGYDDALELTDDYLYPPLRIPHESSTELNHFGYQFLQKAFEKHDLDEDGAL 324

Human   326 SPVELQSLFSVFPAAPWGPELPRTVRT-EAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTL 389
            ||.||||.|||||..||||||..||.| :.|.|||||||||||||.||||..||.||||||||.|
 Frog   325 SPSELQSFFSVFPYTPWGPELASTVCTAQGGYLPLHGYLCQWTLVAYLDVHRCLEHLGYLGYPIL 389

Human   390 CEQD-QAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPG 453
            |||: |.|||||||||.:|.|||||||:|.||:|:|.||.||||||:||||:.|..|....:||.
 Frog   390 CEQESQTHAITVTREKSIDLEKGQTQRNVFLCRVIGPRGTGKSAFLRAFLGQSLEEQQQSNKPPS 454

Human   454 -YAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQ 517
             |:::||.|.||||||||.||..|.....:.||.|||||||:|.||.|||.:|||:||.|||:.|
 Frog   455 FYSVNTVLVGGQEKYLILFEVDVDTEFLKTSDAPCDVACLMYDVSDSKSFNYCASIYKQHYMESQ 519

Human   518 TPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVH 582
            ||||||..|.|..|.....|.||||||.|||||.|..|:|.|  .|..||:::|||.||||||..
 Frog   520 TPCLFVGCKYDQGEVKQQHGISPAEFCHKHRLPPPYHFTCQG--TPDRTIYSKLATAAAFPHLHD 582

Human   583 AELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ 619
            .||..:|||||..|   ||.||||:.|:||:.|::|:
 Frog   583 TELSTASFWLRVAL---GATVAAVVGFTLYKALLRSK 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT2	NP_001339204.1	Miro1	3..169	CDD:206680	132/165 (80%)
		EF_assoc_2	221..304	CDD:462444	63/82 (77%)
		EF_assoc_1	342..409	CDD:462443	51/68 (75%)
		Miro2	414..590	CDD:206679	101/176 (57%)
rhot2	NP_001006725.1	Miro1	3..169	CDD:206680	132/165 (80%)
		EF_assoc_2	220..303	CDD:462444	63/82 (77%)
		FRQ1	<307..>346	CDD:444056	29/38 (76%)
		EF_assoc_1	341..410	CDD:462443	51/68 (75%)
		Miro2	415..590	CDD:206679	101/176 (57%)