Protein Alignment RHOT2 and Miro

DIOPT Version :10

• Sequence 1: NP_001339204.1
• Gene: RHOT2 / 89941
• HGNCID: 21169
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_651205.2
• Gene: Miro / 42845
• FlyBaseID: FBgn0039140
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 664
• Identity: 309/664 - (46%)
• Similarity: 420/664 - (63%)
• Gaps: 57/664 - (8%)

Human     2 RRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDE 66
            |::|||||:|:|.|||||||||||.||:|||||||||||||||:||||:|||.|||:|..||:::
  Fly     9 RKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSED 73

Human    67 ELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLV------------------NGGTTQGP-RVP 112
            .|..||:||:|||:||.|.::.|:::|.:.|:|||                  .|.|.:.| |.|
  Fly    74 ALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKP 138

Human   113 IILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPE 177
            |:|||||.||...|:|::||.||..:||||:|||||||:|.||||:||||||||||||:|||..|
  Fly   139 IVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMME 203

Human   178 AKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQQKSCFGHPLAPQALEDVKTVVCRNVAGGV 242
            .::|..||.::|.|||::.|.|.|..|:|.|||.||:: ||..||.||.|::||.|:.:||..|:
  Fly   204 EQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRR-CFNTPLQPQILDEVKAVIQKNVPDGI 267

Human   243 REDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGY 307
            ..|.:||.|||||:.|||||||:||||.:||||||:|.||:..:||.|.:.:|||.||||:|.|.
  Fly   268 YNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQ 332

Human   308 QFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPW--GPELPRT--VRTEAGRLPLHGYLCQWTL 368
            ||:..|||::|:|.||||||.|.:.|||..|||||  ..::.::  :....|.:.|||:||:|||
  Fly   333 QFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTL 397

Human   369 VTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAF 433
            :|.:||...:.:|.|||:.......|..||.||||:|:|..|.|:.|||..|.|:|.:|.||:..
  Fly   398 MTLIDVVKTMEYLAYLGFNVHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGM 462

Human   434 LQAFLGRGLGHQDTREQPPGY--AIDTVQVNGQEKYLILCEVGTDGLL--ATSLDATCDVACLMF 494
            .:.||...:.....:|.....  .|::|||.||||:|||.::.....|  ....:..||||||::
  Fly   463 CRGFLVEDMHKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVY 527

Human   495 DGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAG 559
            |.|:|:||.:.|.:|..:|.:.:.|.:.|.:|.|:.|........|:|||.|::|..|..||.
  Fly   528 DSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLFSL-- 590

Human   560 PAEPSTTIFTQLATMAAFPHLVHA--------------ELHPSSF---------WLRGLLGVVGA 601
             ......::|:||||||||....|              ..|...|         ||:..|||
  Fly   591 -KTNKKELYTKLATMAAFPRFQAAWILFYKHRLVQLWESAHLRQFGLMTEDPKLWLKAGLGV--- 651

Human   602 AVAAVLSFSLYRVL 615
            |.|.:|.|.:.:.:
  Fly   652 AAATMLGFIVLKTI 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT2	NP_001339204.1	Miro1	3..169	CDD:206680	109/184 (59%)
		EF_assoc_2	221..304	CDD:462444	49/82 (60%)
		EF_assoc_1	342..409	CDD:462443	26/70 (37%)
		Miro2	414..590	CDD:206679	63/193 (33%)
Miro	NP_651205.2	Miro1	10..195	CDD:206680	109/184 (59%)
		EF_assoc_2	245..329	CDD:462444	49/83 (59%)
		FRQ1	<333..>360	CDD:444056	15/26 (58%)
		EF_assoc_1	367..437	CDD:462443	25/69 (36%)
		Miro2	444..620	CDD:206679	62/178 (35%)