Protein Alignment RHOT2 and miro-1

DIOPT Version :10

• Sequence 1: NP_001339204.1
• Gene: RHOT2 / 89941
• HGNCID: 21169
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_500620.1
• Gene: miro-1 / 177238
• WormBaseID: WBGene00019544
• Length: 625
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 280/634 - (44%)
• Similarity: 389/634 - (61%)
• Gaps: 39/634 - (6%)

Human     4 DVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEEL 68
            ||||:|:|:...|||||::||:.:|:.:.||.|.:.:.||||||||.|.|.|||.|..|:.:..:
 Worm     9 DVRIVLIGDEGCGKTSLVMSLLEDEWVDAVPRRLDRVLIPADVTPENVTTSIVDLSIKEEDENWI 73

Human    69 REEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLP 133
            ..||.:|||:||||.|::|:|::.|:|||:||:.....:....|:|||||||| .:.::.:.:||
 Worm    74 VSEIRQANVICVVYSVTDESTVDGIQTKWLPLIRQSFGEYHETPVILVGNKSD-GTANNTDKILP 137

Human   134 IMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQ 198
            ||....|:||||||||:.::|:||:||||||||::||.||||.:.|||.....:||.|:|::.|:
 Worm   138 IMEANTEVETCVECSARTMKNVSEIFYYAQKAVIYPTRPLYDADTKQLTDRARKALIRVFKICDR 202

Human   199 DLDQALSDEELNAFQQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRG 263
            |.|..|||.|||.| ||.|||.||...||||||..|......||..|.|.|.|||:|:.|||:||
 Worm   203 DNDGYLSDTELNDF-QKLCFGIPLTSTALEDVKRAVSDGCPDGVANDSLMLAGFLYLHLLFIERG 266

Human   264 RHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPV 328
            ||||||.:||:|||..:|:|:.|||.|.|.:|.||||||:..|.|||..:|||:|:|:||.|||.
 Worm   267 RHETTWAVLRKFGYETSLKLSEDYLYPRITIPVGCSTELSPEGVQFVSALFEKYDEDKDGCLSPS 331

Human   329 ELQSLFSVFPAAPWGPELPRTVRT-EAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYP----- 387
            |||:||||.|......:....:.| :.|.|..:||:..|.:.|.:::......|.|||:|
 Worm   332 ELQNLFSVCPVPVITKDNILALETNQRGWLTYNGYMAYWNMTTLINLTQTFEQLAYLGFPVGRSG 396

Human   388 ------TLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGH-- 444
                  ||      .:|.||||::.|.|...|.|.|..|.||||:..||:.|:|:..|||:..
 Worm   397 PGRAGNTL------DSIRVTRERKKDLENHGTDRKVFQCLVVGAKDAGKTVFMQSLAGRGMADVA 455

Human   445 QDTREQPPGYAIDTVQVNGQEKYLILCEVGT----DGLLATSLDATCDVACLMFDGSDPKSFAHC 505
            |..|...| :.|:.|:|..:.|||:|.||..    |.|  .|.:.:.||...::|.|:|.|||.|
 Worm   456 QIGRRHSP-FVINRVRVKEESKYLLLREVDVLSPQDAL--GSGETSADVVAFLYDISNPDSFAFC 517

Human   506 ASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQ 570
            |:||:.::...:|||:.:::|.:..|........|.||||:..||.|:.||.....:.|:.||.|
 Worm   518 ATVYQKYFYRTKTPCVMIATKVEREEVDQRWEVPPEEFCRQFELPKPIKFSTGNIGQSSSPIFEQ 582

Human   571 LATMAAFPHLVHAELHPSSFWLR--GLLGVV--GAAVAAVLSFSLYRVL 615
            ||.||.:|||...      |:|.  .||..:  |||:.|:..|.:.:.|
 Worm   583 LAMMAVYPHLRRV------FYLNDSNLLSKITFGAAIVALAGFLVLKNL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT2	NP_001339204.1	Miro1	3..169	CDD:206680	83/164 (51%)
		EF_assoc_2	221..304	CDD:462444	48/82 (59%)
		EF_assoc_1	342..409	CDD:462443	20/78 (26%)
		Miro2	414..590	CDD:206679	67/181 (37%)
miro-1	NP_500620.1	Miro1	9..173	CDD:206680	83/164 (51%)
		EF-hand_7	190..>235	CDD:463900	26/45 (58%)
		EF_assoc_2	224..307	CDD:462444	48/82 (59%)
		FRQ1	<311..370	CDD:444056	26/58 (45%)
		EF_assoc_1	352..418	CDD:462443	20/71 (28%)
		Miro2	423..592	CDD:206679	65/171 (38%)