DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAPLN and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	74/369 - (20%)
Similarity:	121/369 - (32%)	Gaps:	141/369 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   924 GQLVRLSCSDDTAPESQAAWQKDGQPI--------------------SSDRHRLQFDGSLIIHPL 968
            |:.|:|:||.......:.||....|..                    ..|:||..|   |.|:.:
  Fly    66 GRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWF---LHINNV 127

Human   969 QAEDAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIP 1033
            |.||.|.|.|........:|...::::                                    :|
  Fly   128 QEEDRGRYMCQINTVTAKTQYGFVKVV------------------------------------VP 156

Human  1034 SSHPQPANRLRLDQNQPRVVDA--------SPGQRIRMTCRAEGFPPPAIEWQR-DGQPVSSPR- 1088
                            |.:.||        ..|..:.:.|:|:|.|.|.|:|:| ||..:...:
  Fly   157 ----------------PNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKT 205

Human  1089 ---HQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVT------- 1143
               |.|:.| ||.:.|::....|.|.|:|.|                    |:||:|:
  Fly   206 LEVHDLETD-SLELERISRLHMGAYLCIASN--------------------GVPPSVSKRIKVSV 249

Human  1144 --------------VPEGDTARLLCVVAGESVNIR-WSRNGLPVQADGHRV-------HQSPDGT 1186
                          :|.|....|.|.:.....::. |:|....:..:..:.       |.|...|
  Fly   250 DFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKAT 314

Human  1187 --LLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQP 1228
              |.|.|:::.|.|:|.|.|......:..:.::.:.|| ||.||
  Fly   315 MRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSP-PTTQP 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767
		Ig	914..>978	CDD:325142	19/73 (26%)
		I-set	1049..1119	CDD:254352	25/82 (30%)
		IG	1139..1219	CDD:214652	20/110 (18%)
		PLAC	1235..1267	CDD:312271
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/127 (17%)
		Ig	69..139	CDD:143165	19/72 (26%)
		IG_like	165..249	CDD:214653	26/104 (25%)
		IGc2	172..237	CDD:197706	22/85 (26%)
		IG_like	267..348	CDD:214653	16/80 (20%)
		Ig	270..339	CDD:299845	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900