DRSC/TRiP Functional Genomics Resources

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Protein Alignment PAPLN and dpr3

DIOPT Version :9

Sequence 1:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens
Sequence 2:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster


Alignment Length:461 Identity:99/461 - (21%)
Similarity:139/461 - (30%) Gaps:145/461 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   878 WPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLVRLSCSDDTAPESQAA 942
            ||:       ..||...|.|...|..|        |..|:|       ...||.|...:|...||
  Fly   124 WPF-------CNGLAAAAASTGQPDDS--------GDGPTL-------STFLSSSQSQSPSPPAA 166

Human   943 WQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAEL 1007
            ......|.|       |....:.|..|.|        :|.....|........|.|:...::|:.
  Fly   167 SASASSPSS-------FSSFAVAHGPQTE--------ATNHTFKSLAFLDASFGSDLFAQTDAKR 216

Human  1008 SRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQ-RIRMTCRAEGFP 1071
            .|.....:.:||            ..:|...|.    .|...||.:....|. ...:.||.:...
  Fly   217 ERSGAADEESQD------------ADTSQSLPI----FDFGMPRNITGRTGHTEAIIKCRVDSLH 265

Human  1072 PPAIEW--QRD--------GQPVSSPRHQL-----QPDGSLVISRVAVEDGGFYTCVAFNGQDRD 1121
            ..::.|  :||        ....|..|.|:     ..:.:|.:.....:|.|.|.| ..|.:.:.
  Fly   266 DKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYEC-QVNTEPKM 329

Human  1122 QRWVQLRVL-----GELTISGLPPTVTVPEGDTARLLCVVAGESVN----IRWSRNG---LPVQA 1174
            ....||.::     .:..||| ||.:....|....|.|:|...||.    |.|.|..   .|..|
  Fly   330 SMAFQLNIIEISPDAKAVISG-PPDLHFKAGSAIILNCLVQQPSVKDIGPIYWYRGEHMITPFDA 393

Human  1175 D----------GHRVHQSPDGT--------------------------------LLIYNLRARDE 1197
            |          |......|:.|                                |.|.|.:..|.
  Fly   394 DDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDT 458

Human  1198 GSYTCSAYQGSQAVSRSTEVKVVSPA-PTAQPRDPGRDC-----------VDQPELANCDLILQA 1250
            |:|||   |.:.|.|.|..|.|::.. |.|..:.....|           :..|||    |:|:|
  Fly   459 GNYTC---QPTTASSASVLVHVINDENPAAMQKSGACPCALGPLQLLLHLLLLPEL----LLLRA 516

Human  1251 QL-CGN 1255
            .| .||
  Fly   517 GLAAGN 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559
ADAM_spacer1 183..298 CDD:310520
TSP1 308..361 CDD:214559
TSP1 369..424 CDD:214559
TSP1 424..481 CDD:214559
TSP1 488..539 CDD:214559
Kunitz_BPTI 753..805 CDD:278443
Papilin_u7 814..905 CDD:318767 7/26 (27%)
Ig 914..>978 CDD:325142 14/63 (22%)
I-set 1049..1119 CDD:254352 17/85 (20%)
IG 1139..1219 CDD:214652 30/128 (23%)
PLAC 1235..1267 CDD:312271 10/33 (30%)
dpr3NP_001014459.2 Ig 243..330 CDD:299845 17/87 (20%)
IG_like 243..329 CDD:214653 17/86 (20%)
Ig 350..464 CDD:299845 26/117 (22%)
IG_like <441..477 CDD:214653 13/38 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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