DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SELENBP1 and CG7966

DIOPT Version :9

Sequence 1:	NP_001245218.1	Gene:	SELENBP1 / 8991	HGNCID:	10719	Length:	514	Species:	Homo sapiens
Sequence 2:	NP_650256.2	Gene:	CG7966 / 41610	FlyBaseID:	FBgn0038115	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	252/485 - (51%)
Similarity:	335/485 - (69%)	Gaps:	16/485 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    42 STATKCGNCGPGYSTPLEAMK-GPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRL 105
            |..|.|.  ||||:|||:||: ||||:::|...:..|......|||:||||||:||.|||::||.
  Fly     2 SNKTCCR--GPGYATPLDAMRSGPREKLLYTVTVQPNLDEPHGDYLSTVDVDPESPTYCQIVHRT 64

Human   106 PMPNLKDELHHSGWNTCSSCF--GDSTKS---RTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIE 165
            ......|||||||||.||||:  .:|:|:   |.:||||||.|..||::||.::||.|::.|.|:
  Fly    65 FTNRKGDELHHSGWNACSSCYYVDESSKTVPKRDRLVLPSLNSDFIYILDVVTDPRKPEIVKTID 129

Human   166 PKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGY 230
             .|:.....:...||:||||:|.:|||.:||.:|..||.|:|.|.: |...|||.:....|..||
  Fly   130 -GDVLKSHNVTAPHTTHCLANGNIMISVMGDAEGYAKGDFILFDSD-FNCIGTWTKGDKKALCGY 192

Human   231 DFWYQPRHNVMISTEWAAPNVLRDGFNPADVE-AGLYGSHLYVWDWQRHEIVQTLSL-KDGLIPL 293
            ||||||..:||:|:||.|||..|.|:...|:| ...||..|..:.|....:.||:.| .||:.||
  Fly   193 DFWYQPYFDVMVSSEWGAPNKWRRGWKNVDLEDMSQYGCRLNFYKWSTQTLYQTIDLGSDGITPL 257

Human   294 EIRFLHNPDAAQGFVGCALSSTIQRF-YKNEGGTWSVEKVIQVPPKKVK--GWLLPEMPGLITDI 355
            ||||||||..|:|||||||::.:..| .|::...:..:|||.:|.|.|.  ..:..:|.|:|:||
  Fly   258 EIRFLHNPKKAEGFVGCALNAKVFHFKKKSDSDEFEAKKVIDIPGKLVDTGSGVAEDMGGMISDI 322

Human   356 LLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGP-VQVLEDEELKSQPEPLV 419
            ::||||||||.:.|.|||:|||||:||:.|:|||||||||:|....| |.|.||:|||.:|....
  Fly   323 IISLDDRFLYVNCWRHGDVRQYDITDPENPKLTGQLFLGGAICSDLPNVIVKEDKELKERPPARY 387

Human   420 VKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNF 484
            |||:|:.|||||:||||||||||:::||||.|||||||.::.:|..::.:|||||.||:.||.:|
  Fly   388 VKGRRLEGGPQMLQLSLDGKRLYVSSSLYSPWDKQFYPKMVSQGGHIVLIDVDTVNGGISLNEDF 452

Human   485 LVDFGKEPLGPALAHELRYPGGDCSSDIWI 514
            ||||..||.||:|.||:|||||||:||||:
  Fly   453 LVDFANEPYGPSLPHEMRYPGGDCTSDIWL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SELENBP1	NP_001245218.1	SBP56	49..514	CDD:283374	248/476 (52%)
CG7966	NP_650256.2	SBP56	6..482	CDD:283374	249/479 (52%)
CG7966	NP_650256.2	LVIVD repeat	321..358	CDD:293789	25/36 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153123
Domainoid	1	1.000	496	1.000	Domainoid score	I358
eggNOG	1	0.900	-	-		E1_KOG0918
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2930
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1393
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61143
OrthoDB	1	1.010	-	-		D227621at33208
OrthoFinder	1	1.000	-	-		FOG0003227
OrthoInspector	1	1.000	-	-		oto88557
orthoMCL	1	0.900	-	-		OOG6_104861
Panther	1	1.100	-	-	LDO	PTHR23300
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5418
SonicParanoid	1	1.000	-	-		X2649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800