Protein Alignment TRPA1 and pyx

DIOPT Version :10

• Sequence 1: XP_011515926.1
• Gene: TRPA1 / 8989
• HGNCID: 497
• Length: 1144
• Species: Homo sapiens
• Sequence 2: NP_612015.1
• Gene: pyx / 38037
• FlyBaseID: FBgn0035113
• Length: 956
• Species: Drosophila melanogaster
• Alignment Length: 1107
• Identity: 236/1107 - (21%)
• Similarity: 402/1107 - (36%)
• Gaps: 317/1107 - (28%)

Human   102 ELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKF-----LLSRGANPNLRNFNMMAPLH 161
            |..|...|....::|.::|:...|.......|:.::.|:.     |::..|:.||      |.:.
  Fly    47 EAHEIFARQQQNQILWDLDEVKETLTESPGGKHVVDMVQSGCFLELMTDSADCNL------ALIC 105

Human   162 IAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGC-- 224
            .:|.|.....: .||:|...|.|:....|.|.:..||...|:...::||..||.|   |:|..
  Fly   106 CSVFGSVENTL-FLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADP---NRWDARK 166

Human   225 --FPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNG 287
              ..:|.||.|.|.||:.::||        |:..|| :...|.:.||.|:....::.:::.|..|
  Fly   167 EVTSLHCAASSKSVECILLLLR--------RKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYG 222

Human   288 AQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADY 352
            |  ||                                   ||.....||.||.||.....:....
  Fly   223 A--DP-----------------------------------NTPQVYTETPLHTASAAGFAKCVQL 250

Human   353 LISVGADINKIDSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKN 416
            |:|..||:.....||: :.|.||..:.......|||...|:||.     ||..|.
  Fly   251 LLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDC-----RNASHQ---------- 300

Human   417 LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA-AS 480
                                   ||||.||.....|:|:.|:.:..::::..:|.::.||.| ..
  Fly   301 -----------------------TPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVK 342

Human   481 YGR-INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALH 544
            ..| ::.|..||:..:|   :|:.|.:|.||||:||.|.....|...::.||
  Fly   343 QSRSLDCCNALLKAGAD---VNKADNYGYTPLHIAALNEFSSCVYTFIEHGA------------- 391

Human   545 HASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFL 609
                               ..|.|.|             |...|::.::....:|:
  Fly   392 -------------------DITARTD-------------GRVSALSFIVRRTPEII--------- 415

Human   610 HLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTE-- 672
                                                          |:.|:.|......:..|
  Fly   416 ----------------------------------------------PKLMQKLDSSIKANDQEIG 434

Human   673 DKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWL 737
            |..|            |..|:|....|:..:.......|.::::..:..:|.||:|:.:|.:||.
  Fly   435 DVDC------------QIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRILMHPLCETFLFLKWR 487

Human   738 AYGFRAHMMNLGSYCLGLIPMTILVV------------NIKPGMAFNSTGIINETSDHSEILDTT 790
            ... :..:|:|..:.|.:|..|..|:            .:.||
  Fly   488 RIR-KFFLMSLAYHTLFVILFTFYVIWVYVRCCKKEELCVAPG---------------------- 529

Human   791 NSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFV---EIP 852
               .:.|...||.:.::....||..|:....|.|.....|.|:|.|.|..::.|.|..|   ::.
  Fly   530 ---YVSTIGYLVIILNLILLGKEVFQMAHGLRGYAKYWENWLQWTIGTGVLLCVTPETVRTDDLT 591

Human   853 AHLQWQ--CGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYI 915
            |...||  ..||.:...|:..::.:.||...|:::.|...:.....:..:.:|.||:||||||.:
  Fly   592 AVPVWQHHVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAV 656

Human   916 LLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNL 980
            |.|....|.:...|.:::.:||.|::.:.:.|...|   .:..||.:....:||.:.|.::|.||
  Fly   657 LFNDYPAFENITWSFLKSITMMSGELEFEDIFYGDY---AVKFPVTAHIIFLSFVLLVTVILTNL 718

Human   981 LIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKV---------------------D 1024
            ::||||.||..:|..|:|.|:..|.||.:.||.   |:|.|.:                     |
  Fly   719 MVGLAVSDIQGLQVSATLDRLVRQAELVSRLES---LFFSRLLRSAPTNLIQLCKRSALLRTSRD 780

Human  1025 QKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHEL 1089
            :....:.||.||...:...|...::   ::..|..:.::||.....:..|.:  .:..|::|.:.
  Fly   781 KLQFTIRPNDPRDNQLPEDIKLNVY---KLVAERRDRNQSLRRRQFENNYNI--FSRSLQRQQQP 840

Human  1090 IKLIIQKMEIISETEDDD--------------SHCSFQDRFKKE-----QMEQRNSRWNTVLRAV 1135
            :.....|.|..:.|....              |..:...:|::|     ||:.:.:..:.||..|
  Fly   841 LHTDFLKPEPATGTTKKTPQNLFHMHELLRPRSATNVPQQFRQEAEGTVQMKNQANVLSAVLAEV 905

Human  1136 KA 1137
            :|
  Fly   906 QA 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPA1	XP_011515926.1	ANKYR	72..371	CDD:440430	67/278 (24%)
		ANK repeat	92..120	CDD:293786	4/17 (24%)
		ANK repeat	122..153	CDD:293786	7/35 (20%)
		ANK repeat	155..187	CDD:293786	8/31 (26%)
		ANK repeat	189..214	CDD:293786	7/24 (29%)
		ANK repeat	222..261	CDD:293786	13/42 (31%)
		ANKYR	254..544	CDD:440430	68/292 (23%)
		ANK repeat	266..294	CDD:293786	8/27 (30%)
		ANK repeat	296..364	CDD:293786	12/67 (18%)
		ANK repeat	366..397	CDD:293786	11/31 (35%)
		ANK repeat	437..468	CDD:293786	9/30 (30%)
		ANK repeat	470..504	CDD:293786	10/35 (29%)
		ANK repeat	506..536	CDD:293786	11/29 (38%)
		Ank_2	511..602	CDD:463710	14/90 (16%)
		ANK repeat	538..570	CDD:293786	2/31 (6%)
		ANK repeat	572..597	CDD:293786	2/24 (8%)
		Ion_trans	<821..997	CDD:459842	53/180 (29%)
pyx	NP_612015.1	Ank_2	88..161	CDD:463710	22/82 (27%)
		ANK repeat	102..130	CDD:293786	8/28 (29%)
		ANK repeat	132..163	CDD:293786	11/33 (33%)
		ANKYR	148..435	CDD:440430	95/476 (20%)
		ANK repeat	166..196	CDD:293786	12/38 (32%)
		ANK repeat	200..229	CDD:293786	10/65 (15%)
		ANK repeat	231..262	CDD:293786	10/30 (33%)
		ANK repeat	268..296	CDD:293786	9/32 (28%)
		ANK repeat	298..329	CDD:293786	10/63 (16%)
		ANK repeat	331..364	CDD:293786	10/35 (29%)
		ANK repeat	366..396	CDD:293786	12/61 (20%)
		Ion_trans	<562..734	CDD:459842	51/174 (29%)