DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF628 and znf628

DIOPT Version :9

Sequence 1:	NP_149104.3	Gene:	ZNF628 / 89887	HGNCID:	28054	Length:	1059	Species:	Homo sapiens
Sequence 2:	XP_002941933.2	Gene:	znf628 / 100489381	XenbaseID:	XB-GENE-5996090	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	1208	Identity:	529/1208 - (43%)
Similarity:	677/1208 - (56%)	Gaps:	266/1208 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     5 MVGS-HADMAPASTAEGAGEKPGPAAPAPAAQYECGECGKSFRWSSRLLHHQRTHTGERPYKCPD 68
            |||: ..:|:...|. ...:.|.....:...||||.||||.|:|||||:||||||||||||||.:
Frog     1 MVGAQQLEMSELQTT-SVQQPPVQTVESNDHQYECHECGKVFKWSSRLIHHQRTHTGERPYKCTE 64

Human    69 CPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSVHTGLRAFICGQCGLAFKWSS 133
            ||||||||||||||||.|||||||:|..|.||||||||||||:|||||:::|.|..||:||||||
Frog    65 CPKAFKGSSALLYHQRSHTGERPYKCESCGKAFKRSSLLQIHQSVHTGVKSFKCNICGMAFKWSS 129

Human   134 HYQYHLRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYTCGVCGKSFTQSTNLRQHQRVH 198
            |||||:|||||||||.|..|.|||||||||||||::|||||||.|.:|||:||||||||||||:|
Frog   130 HYQYHVRQHTGERPYQCNVCEKAFKNSSSLRRHRNIHTGERPYECAICGKAFTQSTNLRQHQRIH 194

Human   199 TGERPFRCPLCPKTFTHSSNLLLHQRTHGAAPAPGTASAAPPPQSREPGKVFVCDAYLQRHLQPH 263
            |||||::|..|.|:||||||||||||||         ||....:....||||:.|::||:|||.|
Frog   195 TGERPYKCEDCGKSFTHSSNLLLHQRTH---------SAGVSHKCEICGKVFISDSFLQKHLQSH 250

Human   264 SPPAPPAPPPPPPPVVPELFL----------AAAETTVELVYRCDGCEQGFSSEELLLEHQPCPG 318
            :              :.:.|:          .||..|||:|::|..||..|.:|:|||.||....
Frog   251 A--------------IEQAFVHAEAEVYLTTTAAVETVEMVFKCGDCEMTFKNEDLLLGHQQTHV 301

Human   319 PDAAPQPQEAPAEAPKADQPPSPLPQPPPPAAAPAPGFACLPCGKSFRTVAGLSRH-QHSHGAAG 382
            ....|                                  |..|.|:|:..:||||| ||.|.:.
Frog   302 EQIYP----------------------------------CTNCDKTFKNPSGLSRHNQHCHSSE- 331

Human   383 GQAFRCGSCDGSFPQLASLLAHQQCHVEEAAAGRPPPQAEAAEVTCPQ--EPLAPAAPVPPPPPS 445
             :.|:|..|:.:|.||::||.||:.|.||    :...|.| |||||||  |.:.|:...|
Frog   332 -RPFKCSICEKTFVQLSNLLVHQRTHTEE----QQFIQTE-AEVTCPQTSEIIQPSTATP----- 385

Human   446 APASAERPYKCAECGKSFKGSSGLRYHLRDHTGERPYQCGECGKAFKRSSLLAIHQRVHTGLRAF 510
            |..:.:|.|||.||||.|||:||||||:|||||||||:|.||||||||||||:||||||||:|||
Frog   386 ATETVDRQYKCTECGKVFKGTSGLRYHMRDHTGERPYKCSECGKAFKRSSLLSIHQRVHTGVRAF 450

Human   511 TCGQCGLTFKWSSHYQYHLRLHSGERPYACGECGKAFRNTSCLRRHRHVHTGERPHACGVCGKSF 575
            .|.:||||||||||||||||.|:|||||.|.:|||:|:|||||||||.:||||||..|.:|||:|
Frog   451 KCAECGLTFKWSSHYQYHLRQHTGERPYTCTDCGKSFKNTSCLRRHRQLHTGERPFTCLMCGKTF 515

Human   576 AQTSNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHSAERPFTCPICGRGFVMAAYLQRH 640
            .||||||||:|.||||||::|..|.|:|||||||.|||||||:::||.|.:||:.|||::|||||
Frog   516 TQTSNLRQHERTHTGERPYKCDKCDKSFTHSSNLQLHQRTHSSDKPFKCTVCGKSFVMSSYLQRH 580

Human   641 LRTHAPAN--TPPSTTAPAAGPQPPAPLAAARAPPATQDVHVLPHLQATLSLEVAGGTAQAPSLG 703
            ||||..|.  |..::|......|....|      |....|.::|.:.|.|:.|   |:.|
Frog   581 LRTHVSATLVTTENSTQNIQNSQNIQVL------PNNPGVQIIPSMPAPLTFE---GSNQ----- 631

Human   704 PAAPNSQTFLLVQTAQGLQLIPSSVQPPTPPPPPAPPKLILLPSS-------------------- 748
            |:..|.|||:|||.          ||..|       |||:|||::
Frog   632 PSGSNPQTFVLVQV----------VQQNT-------PKLLLLPNTQLFQTQQKVPIAVNTSSVSL 679

Human   749 ----------SAGAGGGRARQ-GPRAVGKAGQGAGVVWLPGPGGL-------------GVQGAAS 789
                      .:..|..|::| .|.|.........:|.:|..|.:             .:||:..
Frog   680 VQDNSQQRNLQSKPGRRRSKQKKPAAPFNVAPNHNIVIMPNTGHVVPNIQTLQNVQFQAIQGSPR 744

Human   790 AGASGTGQSLIVLQNVGGGEAGPQEMSGVQLQPLRPAPEVTTVQLQPA----------------- 837
            ..:...||:::|||||  .:.|..:::.:|:..:..:.:...:|:|||
Frog   745 TQSLPLGQNVLVLQNV--SDQGSHQLANMQINAISSSQKTPNIQIQPAPMTRDMANVHIQTSTTP 807

Human   838 QEVTTVQLQ---PAQEVTTVQLQ---PAQEVTTVQLQPVAG----------QLSNSSGGAVATEA 886
            |:|:.::::   .:||:..:|:|   .||.::.|.:|.||.          .||.|.|.....|:
Frog   808 QDVSGIRIRTVSSSQEIPNLQIQTVPSAQAISNVHVQAVANTPDLSNIQIQTLSGSQGVTGLQES 872

Human   887 PNLLVVQSGAAEELLTGPGPGEAGDGEASTGVVQDVLFETLQTDEGLQSVLVLSGADGEQTRLCV 951
            .||:|||: :.||:|:.   ||:.:...|...|.||..|||||:||||:|:||..|:||||||||
Frog   873 QNLIVVQN-SPEEILSA---GESVENLQSMEDVHDVHIETLQTEEGLQNVIVLQNANGEQTRLCV 933

Human   952 QEVETLP-------------PGLTEPPATGPPGQKLLIIRSAPATELLD---------------- 987
            ||||.:.             ..|.:|....|.|||:.||:|:...:.|.
Frog   934 QEVEDIQNLQDVQNVQIQAMTNLQKPTTAIPAGQKVFIIQSSQGEQTLQVVDNIQGDQNVQVVEN 998

Human   988 -------------SSNTGGGTA----TLQLLAPPPSGPASGPAGLPGAPASQMVQVVPAGAGPGV 1035
                         |:|...||.    .|||.|.|.:      .|:......|..|.:|.......
Frog   999 THSLQGGQNIQMVSNNHNPGTVQILQNLQLRAIPNN------QGIQAIQNVQNFQSIPTTTNENQ 1057

Human  1036 MTP--------------QGLPSIQIVQTLPAVQLVHTF 1059
            ..|              |||||||||||:|.|||||||
Frog  1058 TIPTVELVQKSPVQGLQQGLPSIQIVQTVPKVQLVHTF 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF628	NP_149104.3	C2H2 Zn finger	38..58	CDD:275368	15/19 (79%)
		COG5048	<43..213	CDD:227381	134/169 (79%)
		C2H2 Zn finger	66..86	CDD:275368	17/19 (89%)
		C2H2 Zn finger	94..114	CDD:275368	15/19 (79%)
		C2H2 Zn finger	122..142	CDD:275368	15/19 (79%)
		C2H2 Zn finger	150..170	CDD:275368	15/19 (79%)
		C2H2 Zn finger	178..198	CDD:275368	16/19 (84%)
		zf-C2H2	204..226	CDD:306579	15/21 (71%)
		C2H2 Zn finger	206..226	CDD:275368	15/19 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280		3/19 (16%)
		C2H2 Zn finger	297..314	CDD:275368	8/16 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..351		3/38 (8%)
		C2H2 Zn finger	361..378	CDD:275370	10/17 (59%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		COG5048	<453..642	CDD:227381	142/188 (76%)
		C2H2 Zn finger	456..476	CDD:275368	15/19 (79%)
		C2H2 Zn finger	484..504	CDD:275368	17/19 (89%)
		C2H2 Zn finger	512..532	CDD:275368	17/19 (89%)
		C2H2 Zn finger	540..560	CDD:275368	14/19 (74%)
		C2H2 Zn finger	568..588	CDD:275368	14/19 (74%)
		C2H2 Zn finger	596..616	CDD:275368	14/19 (74%)
		C2H2 Zn finger	624..644	CDD:275368	13/19 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..674		6/31 (19%)
		4 X approximate tandem repeats. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	818..864		13/68 (19%)
		Interaction with TAF4B. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	943..1059		53/175 (30%)
znf628	XP_002941933.2	C2H2 Zn finger	34..54	CDD:275368	15/19 (79%)
		zf-H2C2_2	46..70	CDD:404364	20/23 (87%)
		C2H2 Zn finger	62..82	CDD:275368	17/19 (89%)
		zf-H2C2_2	74..99	CDD:404364	19/24 (79%)
		C2H2 Zn finger	90..110	CDD:275368	15/19 (79%)
		C2H2 Zn finger	118..138	CDD:275368	15/19 (79%)
		COG5048	142..576	CDD:227381	271/502 (54%)
		C2H2 Zn finger	146..166	CDD:275368	15/19 (79%)
		C2H2 Zn finger	174..194	CDD:275368	16/19 (84%)
		C2H2 Zn finger	202..222	CDD:275368	15/19 (79%)
		C2H2 Zn finger	230..250	CDD:275368	10/19 (53%)
		C2H2 Zn finger	280..300	CDD:275368	10/19 (53%)
		C2H2 Zn finger	307..328	CDD:275370	11/20 (55%)
		C2H2 Zn finger	336..356	CDD:275368	9/19 (47%)
		C2H2 Zn finger	396..416	CDD:275368	15/19 (79%)
		C2H2 Zn finger	424..444	CDD:275368	17/19 (89%)
		C2H2 Zn finger	452..472	CDD:275368	17/19 (89%)
		C2H2 Zn finger	480..500	CDD:275368	14/19 (74%)
		C2H2 Zn finger	508..528	CDD:275368	14/19 (74%)
		C2H2 Zn finger	536..556	CDD:275368	14/19 (74%)
		C2H2 Zn finger	564..584	CDD:275368	13/19 (68%)
		SP1-4_N	<586..>840	CDD:425404	61/286 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I23408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H72200
Inparanoid	1	1.050	893	1.000	Inparanoid score	I3743
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38139
OrthoDB	1	1.010	-	-		D39995at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto149323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980