Protein Alignment SEC16B and sec16b

DIOPT Version :10

• Sequence 1: NP_001377763.1
• Gene: SEC16B / 89866
• HGNCID: 30301
• Length: 1062
• Species: Homo sapiens
• Sequence 2: XP_068074413.1
• Gene: sec16b / 553356
• ZFINID: ZDB-GENE-050208-274
• Length: 935
• Species: Danio rerio
• Alignment Length: 1047
• Identity: 377/1047 - (36%)
• Similarity: 515/1047 - (49%)
• Gaps: 199/1047 - (19%)

Human    28 RRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHY-----ASRPGDWHQPVSGVD 87
            ||:|...|          .:|:|    |.......|:.||.|.:|     ..|...|.|    ||
Zfish     5 RREGWRMP----------GYQYQ----SSDRDDHYRSSHQSQYYYPPTESRGRERQWQQ----VD 51

Human    88 YYEGGYRNQLYSR----PGYENSYQSYQ----SPTMREEY------------AYGSYYYHGHPQ- 131
            ...|.|......:    |||.::|.|.|    .|..|:||            .||.|.|||:.:
Zfish    52 PRYGSYMTSPPPKPEYIPGYSSAYASNQPSHFRPHSRQEYDYSTSSYWPYREDYGYYDYHGYHRT 116

Human   132 ---------WLQEE--RVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPC 185
                     |.|.:  |....:...:..|..| ..|.|:..|.     |.|:|:.....:.|:
Zfish   117 QYSSPDGGGWSQTDGWRTEGHQGQGLTQESAR-ASYSDQQGYS-----FKTDSQHDRGVSERH-- 173

Human   186 KDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDD 250
            ::|..:.:|   .||::..|.||.:                :.|||||||||||||:..|.:.
Zfish   174 RESMDNGNG---TGEVYDNSALANS----------------KASGLSSSSYELSQYMNGAEQS-- 217

Human   251 PPASAAWSPVQAEDVSSAG----PKAPMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHS 311
                      :.|.:|..|    ..||:||.||||.|||||.||||.|.|:..::|:.|.|||||
Zfish   218 ----------ELELISHTGVVPVEVAPLKFSIPHVAVSFGPAGQLVWVSPALASEGEPAQVELHS 272

Human   312 MEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGSRDS-ALLWQLLVLLC 375
            :||||.|:..|.:||.|.|||.|||:||||.:.|..|.:....|.|.|....| ||||..|:|||
Zfish   273 LEVILCDTHAQHDMRDFPGPLAREDLHKVDAINFAIQMSEMCLKDEKLEDHTSAALLWHFLILLC 337

Human   376 RQNGSMVGSDIAELLMQDCKKLEKYKRQPPVA---NLINLTDEDWPVLSSGTPN---LLTGEIPP 434
            ||||.::|||:|||||::...|..:......|   :||:|::.  |.:...|.|   ||||..|.
Zfish   338 RQNGRILGSDVAELLMRESSSLGVWGDTAEPADGKSLIDLSET--PTVEKETLNFSDLLTGFPPT 400

Human   435 SVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDP 499
            ..|...|.::|:|:||..||||||||.||::..|||||||:||||.::|:.|:|.||.:|..:||
Zfish   401 DKEAEEQNLQKYTKLLLSGRKKEALESAMQSGQWGHALFLASKMDSRSYNTVLSRFTGSLTPSDP 465

Human   500 LQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLVEAA 564
            |||||||:|||||..:.....::||||||||||:|||:..||.::.|:|:|:|||||.:.::.|:
Zfish   466 LQTLFQLLSGRIPAVSMSWSSEKWGDWRPHLAVMLSNETTDPVIHHRSIIAMGDTLASRDMLFAS 530

Human   565 HFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQV 629
            |.|||.|..|||.|..:::.||||||..|..|.||....||:.||:|||||.||..:..||:|||
Zfish   531 HICYLTAQCPFGWYRNRSERLVLLGSKQSVMFSKFCHNSAIRCTELFEYCQRLGNAEFVIPAFQV 595

Human   630 YKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSGD 694
            ||.|||.||.|.||||||.||||.:|.|:| :.:..|.|||.|||||.::||.|:..:.:...|.
Zfish   596 YKFLYACRLLDCGLVSQAFHYCEVVGKALL-RIDQPHVVLLGELIKLVDRLKFSEAQLNDTGDGQ 659

Human   695 RDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGT--TTENTFYQDFSGCQGYSEA----- 752
            ..|:||||.|:|.:.:..    :|:.:.:.:..|.|..|  |.::..|.||:  :|.:||
Zfish   660 LFLDPDWLVQIRCRHQTL----LGENYCSETYQSPAEETSWTQDSNKYSDFT--EGQAEAIDNPS 718

Human   753 -------PGYRSALWLTPEQTCLLQPSPQQPFPLQPGSYPAGGGAGQTGTPRPFYSVPETHLPGT 810
                   |.| ||:..|..|.       :..:.|...||.:...|.:|..|.|.|   .|..|.|
Zfish   719 TETESSNPPY-SAIPHTDAQF-------EGTYSLMSHSYSSEEQAPKTIAPVPLY---PTQQPMT 772

Human   811 GSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKPQTPL-AARPRSISESSAS 874
            ...|..||.             .||  .:||.|.|...|...........: ::.||:.:::...
Zfish   773 LPPVTPTEM-------------FGP--PSVSVEQSYANDSSTYHDDLHNAMSSSSPRNYTDTGGD 822

Human   875 SAKEDEKESSDEADKNSPRNTAQRGKLG--------DGKEHT---KSSGFGWFS-WFRSKPTKNA 927
            .:.|....|         .|.|..||:.        |.|..|   |:|..|||| ||:|||.
Zfish   823 FSAEAMIAS---------ENDATVGKVNQFGTFPSEDNKTKTQSAKASKPGWFSGWFKSKPK--- 875

Human   928 SPAGDEDSSDSPDSEQETPRASSPHQAGLGLSLTPSPESPP-------LPDVSAFSRGRGGGEGR 985
                ||...:.||.:..|..:::..         |.|..||       .|..:.||:..|..:.:
Zfish   876 ----DEPKEEIPDPDSPTEESTANF---------PFPPPPPRSILKTEQPQFNPFSKRAGQSQNQ 927

Human   986 GSASSGG 992
            ....|.|
Zfish   928 QQTLSEG 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC16B	NP_001377763.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		15/62 (24%)
		Required for endoplasmic reticulum localization	34..224		51/226 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..236		17/72 (24%)
		Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000269|PubMed:21768384	272..714		231/448 (52%)
		ACE1-Sec16-like	328..684	CDD:187750	188/362 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..734		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..797		5/25 (20%)
sec16b	XP_068074413.1	ACE1-Sec16-like	289..648	CDD:187750	188/361 (52%)