Protein Alignment SEC16B and Sec16

DIOPT Version :10

• Sequence 1: NP_001377763.1
• Gene: SEC16B / 89866
• HGNCID: 30301
• Length: 1062
• Species: Homo sapiens
• Sequence 2: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Alignment Length: 1337
• Identity: 323/1337 - (24%)
• Similarity: 489/1337 - (36%)
• Gaps: 401/1337 - (29%)

Human    21 KDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQ-----------------PQQEPRADHQQ 68
            :||||.:   .|.|...:|.:.||..:...::.|..:                 ..:|...|:::
  Fly   820 EDPDRSY---DHSRRYNNSNYEGESDNPEYNHMGDAELDGSGGRSSKTSRHRRSAAEEDFDDYER 881

Human    69 QPHYASRPGDWHQPVSGVD--YYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQ 131
            :.:.:.|.   .:|.|..:  ...||.||       ||||.:|.::...|..|
  Fly   882 ERNRSRRS---TKPQSSAEKSRSSGGRRN-------YENSGRSARADDGRRRY------------ 924

Human   132 WLQEERVPRQRSP-----YIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPAS 191
              |::|.|..:.|     |:.:..| ||...:...|.:.::.|...     ..||.|....:.||
  Fly   925 --QDQRNPGAQYPVSATGYVPYGMY-EQMSRNPQVYADMYAKFYGQ-----MINSMNAAVSAAAS 981

Human   192 NSGQEWPGELFPG-----------SLLAEAQKNKPSLASESNLL--------------------- 224
            ..|......:.||           .|:|.......|.:||:.:|
  Fly   982 KGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERYTHAYITQANEFHRHQ 1046

Human   225 -------------------QQRESGLSSS------------------------SYELSQ------ 240
                               ||||..|:||                        ||.||.
  Fly  1047 YKELIYQQQQQQQQQQQQQQQREDHLNSSFSVAEDNASFYGSHGGGSIYNQYQSYPLSSARSLSN 1111

Human   241 ------------YIRDAPERDDPPASAAWSPVQAEDVS-SAGP------------KAPMKFYIPH 280
                        |...:....|..|:|..:|.....|: :|||            :.|::|..||
  Fly  1112 LNGDGRNSRCGPYYAGSECGLDIRAAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPH 1176

Human   281 VPVSFGPG------------GQL---VHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSG 330
            :..|:...            |:|   |.|.|....||.::|                  :|.:.|
  Fly  1177 LVASYAMSLLLKVKPKYAGRGRLRNDVEVAPPRIRDGTSSL------------------LRMYPG 1223

Human   331 PLIREDVHKVDIMTFCQQK----------AAQSCKSETLGS-----RDSALLWQLLVLLCRQNGS 380
            ||....:||..|::||:::          |..:.:.:..||     ...||:|.||:||.||||.
  Fly  1224 PLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALMWHLLILLLRQNGY 1288

Human   381 MVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDED----------------------------W 417
            :..:|:.:||:::   .::|...|......|..|.|                            .
  Fly  1289 IADTDVGDLLLEN---QQEYPYDPSEFEAENEPDADAEQDAAAPADKTVDSDLDSESAAGVTPAE 1350

Human   418 PVLSSGTPNLLTGEIPPSVETPAQ---IVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMD 479
            |:.:....:.:.|....:..||..   ..:||...:..|..:|||:||..|.||.||.||:...|
  Fly  1351 PLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYED 1415

Human   480 PQTYSWVMSGFTS-TLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPEL 543
            ....:.|...|.: .:..|||||||:|:.|...|...:...::||||||.||:::::|::..||.
  Fly  1416 RYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTNKSRQPEY 1480

Human   544 YQRAIVAIGDTLAGKGLVEAAHFCYLMAHVPFGHY----------TVKTDHLVLLGSSHSQEFLK 598
            .:.::||:||||..:|.:.|||||||:|...||.|          |.....|:||||||.:.|.:
  Fly  1481 DRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTANVPRLILLGSSHYKHFNE 1545

Human   599 FATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGE 663
            ||:.|||..|||:||.:.|..||..|..||.||.|.|:|:.|||...:..:|.|.|...:..:.|
  Fly  1546 FASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIELKPE 1610

Human   664 SSHPVLLVELIKLAEKLKLSDPLVLER-------RSGDRDL----EPDWLAQLR----------- 706
            |.....:..:..|||:|:..||:::.|       .:..:|.    |..||.|||
  Fly  1611 SYDSNFIQRVCGLAERLRYHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLRSLAYVQPQQEQ 1675

Human   707 -RQLE--QKVAGDIGDPHPTRSDISG---------AGGTTTENTFYQDFSGC--QGYSEAPGYRS 757
             :||:  |:|..:..|.....::::.         ...:..|||........  |...:.....|
  Fly  1676 LQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNSNMENTLQPQLPPVDQQPPQQQQQVLS 1740

Human   758 ALWLTPEQTCLLQPSPQQPFPL------QPGSYPAGGG-------AGQ--------TGTPRPFYS 801
            ..:..|.|. ..:|.||.|...      ||..|....|       |.|        ...|.|.|.
  Fly  1741 ESYQQPTQQ-YYEPPPQAPTESDPYGQGQPSYYDPNAGQLHYDPNAAQHQYDQQQPQPQPTPSYG 1804

Human   802 V----PETHLPG--TGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKPQTP 860
            .    .|.:.||  |....||....|...|                ..|.|||.|.|.
  Fly  1805 QIEPGTEAYQPGQATADPAAVPSGYGYDYW----------------SGTQQPPYGDEP------- 1846

Human   861 LAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGK-------EHTKSSGFGWF-S 917
                    :|:.|  |.:||:|..:|.|:......|::..|...|       :||:|:|.... :
  Fly  1847 --------NENQA--ALKDEEEEDEEQDEQQILQYAKQQILQQTKQQQLQQEQHTRSNGAASINN 1901

Human   918 WFRSKPTKNASPAGDEDSSDSPDSEQETPRASSPHQAGLGLS-LTP----SPESPP--------L 969
            .|:|...|      .|.||.|....||..|.::...|...:: :||    :..:||        |
  Fly  1902 RFKSNALK------QERSSGSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPAASAKAFNL 1960

Human   970 PDVSAFS----RGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVP 1030
            .|||:||    |.:........:||..|||.|.....:...:|.    :.|..||       :..
  Fly  1961 NDVSSFSSTNKRHQATSSSNNRSSSNQAAAAAAATKAAAIATVP----AAPNQLL-------SCR 2014

Human  1031 LYNPSQVPQLPTATSLNRPNRLAQRR------YPTQP 1061
            ..|....|.|.|..:|..|.|....:      .||.|
  Fly  2015 KSNSQNSPYLATPKTLTTPTRFIAAKAATVTATPTAP 2051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC16B	NP_001377763.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		15/81 (19%)
		Required for endoplasmic reticulum localization	34..224		44/224 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..236		22/147 (15%)
		Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000269|PubMed:21768384	272..714		160/538 (30%)
		ACE1-Sec16-like	328..684	CDD:187750	133/412 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..734		2/30 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..797		10/46 (22%)
Sec16	NP_001285158.1	DUF4813	<279..379	CDD:435117
		ACE1-Sec16-like	1371..1631	CDD:187750	101/259 (39%)