DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SEC16B and sec-16A.2

DIOPT Version :10

Sequence 1:NP_001377763.1 Gene:SEC16B / 89866 HGNCID:30301 Length:1062 Species:Homo sapiens
Sequence 2:NP_509400.3 Gene:sec-16A.2 / 181084 WormBaseID:WBGene00017419 Length:1632 Species:Caenorhabditis elegans


Alignment Length:1155 Identity:253/1155 - (21%)
Similarity:408/1155 - (35%) Gaps:333/1155 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    41 HNGERFHQWQDNRG----------------------SPQPQQEPRADHQQQPHYASRPGDWHQPV 83
            ||....||...:||                      |.:..|||     |:....|...|....|
 Worm   615 HNHSYQHQQMQHRGRHSALGVPFDARRTPSSYIRTFSGEYGQEP-----QETSSISENEDDGDNV 674

Human    84 SGVDYYEGGYRNQLYSRPGYENS-YQSYQSPTMREEYAYGSYYYHG--HPQ---WLQ-------- 134
            ...|...|....:.:.|.||.|: ||..|.|...:..|   .||.|  |..   |.:        
 Worm   675 ESDDELRGFNMERQHERRGYNNAQYQEVQCPIEEDGSA---LYYCGVVHVNMDIWRRITQSYQIP 736

Human   135 ---EERVPRQRSPYIWH-----------EDYREQ------KY-----------------LDEHHY 162
               .|..|.:::.||::           :.:|:|      ||                 :..|:.
 Worm   737 AEFNELKPIEKAAYIFYAVIHKQPCRNLDTFRKQFNFYFYKYGMEGDSDDDALFKVCRTMQNHYI 801

Human   163 ENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEW---------PGELFPGSLLAEAQKNKPSLA 218
            |.|......|     |:.......|..:.:.|..:         |    |.|::|:.|.:..|:.
 Worm   802 ERQREKERAN-----QNMMSTLFSDDTSIDGGNVYSLPNLSTVEP----PKSIIAKRQSDMNSVC 857

Human   219 SESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQAEDVSSAGPKAPMKFYIPHVPV 283
            .||                                      :.|.|:.:.|   |:||..||..:
 Worm   858 EES--------------------------------------LNAYDIYNNG---PLKFTCPHSFM 881

Human   284 SFGPGGQLVHVGPSSPTDGQAALVELHSMEVILND---SEEQEEMRSFSGPLI--REDVHKVDIM 343
            :...|||::.:.|    |...:.|....::.:|.|   .:.::...:|.||||  :...|.|.:.
 Worm   882 NISTGGQIISIRP----DQSISAVVFDDIKSVLKDVPTLQVKDAAMTFKGPLIPHQSAPHTVRLY 942

Human   344 TFCQQKAAQSCKSETLGSR--------DSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKY 400
            .   .|..::.|:..:...        :|.|:||||..:.:|.|::.|.|||||       |.|.
 Worm   943 I---TKQIENIKNSAVAIENPEANDVVESLLIWQLLETMVKQQGNITGPDIAEL-------LAKV 997

Human   401 KRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKN 465
            ..||                       :..|.||.....|..:.:||:.|..|...||:|.|::|
 Worm   998 ASQP-----------------------VQIEAPPQQANIAPALTQFTKFLLGGHIDEAVESALRN 1039

Human   466 HLWGHALFLSSKM---DPQTYSWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWR 527
            .|:..||.|:.::   |.:....:.|.|..|.::::|:.||..:..|..|...|.........|.
 Worm  1040 GLFADALVLTRRLFPNDERRIEQIESRFLQTRSMSNPVTTLVSVAKGESPPVLTNPPLDDHLSWG 1104

Human   528 PHLAVILSN--QAGDPELYQRAIVAIGDTLAGKGLVEAAHFCYLMAHV------------PFGHY 578
            .|.|:||:|  |.| |.:  ..|..:|..||.:....||.||:|:..|            |.|..
 Worm  1105 THAAIILANLDQRG-PAM--NTIYQLGRALAKRDYHSAADFCFLVCGVLGGTNPFEPIATPEGEE 1166

Human   579 TVKTDHLVLLGS------SHSQEFLKFATTEAIQRTEIFEYCQML----GRPKSFIPSFQVYKLL 633
            ..:. |:.|:.|      |:.:....|..|: :..||||:|...|    ..|.:....:|..::.
 Worm  1167 DYRR-HISLVNSDIPDNESNPKCQYGFLLTD-LHATEIFDYALRLKADRESPLTKSVEYQTARIK 1229

Human   634 YASRLADYGLVSQALHYCEAIGAAV-----LSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSG 693
            ||..||::|..:.|..||..:..|:     |.:.:.     |:||..|||.|:.:        :.
 Worm  1230 YAKLLANHGFNTDAYRYCTEVARAIWNNLYLFKADD-----LLELCDLAESLQYA--------AS 1281

Human   694 DRDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTEN----TFYQDF---SGCQGYSE 751
            ....|..|:..||..::   ||.:..|.||::      ....||    :.:|.:   |..|...|
 Worm  1282 VNPSESQWIHDLRTTVQ---AGFVYTPQPTQT------VKHLENKPVPSVHQGYDLQSNAQDDPE 1337

Human   752 APGYRSALWLTPEQTCLLQPSPQQPF---PLQPG----SYPAGGGAGQTGTPRPFYSVPETHLPG 809
            .|  |..:...|....::.|.|....   .:||.    |:|         .....|.....|:|.
 Worm  1338 VP--REPVQHVPITQNVIDPVPTHSAFTPTIQPKDPELSHP---------PQNQVYREEPPHIPP 1391

Human   810 TGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQ---------PPDGQE----VISKPQT-- 859
            |.:.         :|.:|.   |....:.:.||..:|         |||..:    :.|.|.|  
 Worm  1392 TPTP---------SVHQEQ---HYQQFDQSFSQSLTQQAQEDGFMTPPDYSDGPLTMASSPPTLP 1444

Human   860 -----PLAARPRSIS-ESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGWFSW 918
                 |::::|...| |:.|.::...::.:.::..:...||..|.               ||...
 Worm  1445 PVQSVPVSSKPAPPSAENQAQNSTSPQQPTQEQGQETQDRNPDQG---------------GWLKS 1494

Human   919 FRSKPTKNASPAGDEDSSDSPDSEQETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGGE 983
            .:|........|...:..:.|:....:....|.....:|..:...|.:||.|...|......||.
 Worm  1495 IQSTVQNTVQKATGRNPMNLPEDRNPSIVWDSTQNKYVGAGVEQEPVAPPPPMAQAGPAPPVGGG 1559

Human   984 GRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLL---PPPALKGAVP 1030
            |..:|.  ||:..|.|||.|...|.:      |..::   ||.|..|.:|
 Worm  1560 GLRAAR--GASRYARVGGTSSSASQA------PAGMMAPAPPTANFGFIP 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEC16BNP_001377763.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..86 14/66 (21%)
Required for endoplasmic reticulum localization 34..224 53/264 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..236 14/81 (17%)
Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000269|PubMed:21768384 272..714 123/486 (25%)
ACE1-Sec16-like 328..684 CDD:187750 106/397 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..734 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..797 6/32 (19%)
sec-16A.2NP_509400.3 PHA03307 185..>561 CDD:223039
PRK07003 <189..>330 CDD:235906
ACE1-Sec16-like 925..1280 CDD:187750 106/405 (26%)
PRK10263 <1350..>1472 CDD:236669 27/142 (19%)
Med25_SD1 1433..1627 CDD:463244 41/192 (21%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.