Protein Alignment SEC16B and sec16b

DIOPT Version :10

• Sequence 1: NP_001377763.1
• Gene: SEC16B / 89866
• HGNCID: 30301
• Length: 1062
• Species: Homo sapiens
• Sequence 2: XP_031756826.1
• Gene: sec16b / 100488357
• XenbaseID: XB-GENE-6468128
• Length: 978
• Species: Xenopus tropicalis
• Alignment Length: 1118
• Identity: 439/1118 - (39%)
• Similarity: 599/1118 - (53%)
• Gaps: 198/1118 - (17%)

Human     1 MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDN-RGSPQPQQEPRA 64
            |:..||..:.|::|:..| ..||.||.    |...:||...|....:..|.: |....|...|..
 Frog     1 MDRGAPPWVRQSQGRPDA-EMDPWRGL----HPHDIPHQLSNSTYGYYPQPHARSGRPPWPAPWM 60

Human    65 DHQQQPHYASRP--GDWHQPVSGVDYYEGG----YRNQLYSRPGYENSYQSYQSPTMREEYAYGS 123
            |:..| |.|:.|  .:|.:|.|.::..|..    ||.  .||.||:..|..||:...  |...|:
 Frog    61 DYYSQ-HSAAAPWYENWGRPASQMETTERSNTVTYRP--LSRQGYDERYAVYQNTGW--ENNTGA 120

Human   124 YYYHGHPQ-------WLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNS 181
            .|::.||:       ||:|  :.|:::....|.  |.|...|.|.:...:
 Frog   121 DYFYAHPRTMPREEAWLRE--IQRKQTEQWSHG--RPQPQTDSHKWIRGY--------------- 166

Human   182 RNPCKDSPASNSGQEWPGELFPGSLLAEAQK----NKP---SLASESNLLQQRESGLSSSSYELS 239
                        |..|        :|::.|.    :||   |..:.|.|.|.|:||:||||||||
 Frog   167 ------------GDSW--------VLSQEQDGDVLDKPESQSSTAPSILSQYRDSGMSSSSYELS 211

Human   240 QYIRDAPERDDPPASAAWSPVQAEDVSSAGPK--APMKFYIPHVPVSFGPGGQLVHVGPSSPTDG 302
            ||::|:    ||     |:.:|.|::|...|:  ||.||.:|||.|.||..|.||.|.|:.|.:|
 Frog   212 QYLQDS----DP-----WNTMQGEEMSECTPQPTAPFKFSLPHVTVCFGAQGHLVRVCPNFPDEG 267

Human   303 QAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGSRDSALL 367
            |.||||:||:||:|:|:.||||||:|.||:.|||:|||||:.|||...::..|::..||.|.|||
 Frog   268 QPALVEIHSLEVLLHDTVEQEEMRNFPGPVQREDLHKVDIIKFCQHNVSRCLKTKGNGSCDEALL 332

Human   368 WQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVL-SSGTPNLLTGE 431
            ||:|:.:|||||.|.|||:||||:||.|| |:|:.:...||||:|: ||.|:: .....:|||||
 Frog   333 WQILLQMCRQNGCMAGSDVAELLLQDWKK-ERYQVEKHEANLISLS-EDPPLIPDCFQADLLTGE 395

Human   432 IPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLAL 496
            :|.:.||.|:.|||||:||::|||||||:||||:.:|||||||||||||:||||||..||||||.
 Frog   396 MPSASETYAKAVEKFTKLLFFGRKKEALDWAMKSQMWGHALFLSSKMDPRTYSWVMGRFTSTLAQ 460

Human   497 NDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLV 561
            |||||||||.|:|||||||..||:.:||||||||||||||...|.|..:|:::.:||.|..||..
 Frog   461 NDPLQTLFQFMAGRIPQAAMSCGDSKWGDWRPHLAVILSNPMADSETNRRSVITMGDNLVLKGFT 525

Human   562 EAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPS 626
            ||.|.|||.|.:.:|.....:|.:|||||.|::.|.|||:...||.|||.||||.|.:|...:||
 Frog   526 EAGHCCYLSAGIAYGQNCENSDLIVLLGSKHNKSFQKFASLRNIQCTEILEYCQSLRKPMHCMPS 590

Human   627 FQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERR 691
            |||||||||:||.||||.|.||||||.|.:|||:  .|...||:.:||||||:|:.|||.:|:|.
 Frog   591 FQVYKLLYAARLMDYGLTSLALHYCECIASAVLA--HSGSVVLISQLIKLAERLRYSDPRLLDRP 653

Human   692 SGDRDLEPDWLAQLRRQLEQ-----------KVAGDIGDPHPTRSDISGAGGTTTENTFYQD--- 742
            ..::.|:|:||:|||..|.|           .|...:.|.....:|      :.:.||.:.|
 Frog   654 ELEQSLDPEWLSQLRALLRQLQLNAPAARLTPVNDSVQDNKVADTD------SISRNTVHHDEEK 712

Human   743 ----FSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPF--PLQPGSYPAGGGAGQTGTPRPFYS 801
                |.|....||| ||.            ||.:||.|.  |.:..:|       .....:|..|
 Frog   713 TYPMFEGQNLESEA-GYG------------LQCTPQFPAVKPTEVLNY-------SLADSQPVIS 757

Human   802 VPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPP---DGQEVISKPQTPLAA 863
            |   .:|   .|.::.|           |.|.....:::||...|..   :....:..|.  |:.
 Frog   758 V---EVP---QSKSIHE-----------QDHQQESMDSLSQSVCQSSYIHNSDPTVQCPS--LSR 803

Human   864 RPRSISESSASSAKED--EKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGWFSWFRSKPTK- 925
            |.|::||||..|.:||  |:::.|:|....|.:.            .|.|.||||.||||||:|
 Frog   804 RIRTVSESSTVSMEEDGGEEQTEDQAVSKEPNDI------------KKGSSFGWFGWFRSKPSKQ 856

Human   926 NASPAGDEDSSDSPDSEQETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRG---RGGGEGRGS 987
            .|.||      :.|:::.|    .||:...|..| .|....||....:.:|||   :...|.:.:
 Frog   857 TAIPA------EVPETKPE----MSPNAVNLSTS-HPPQYMPPNTKRNLYSRGTDIKAIEEPQNN 910

Human   988 ASSGGAAAGAG-VGGLSGP---ESVSFELCSNPGVLLPPPALKGAVPLYNPSQVPQLPTATSLNR 1048
            .|:...:...| :..:..|   .||:....:.|.         ||||:|||.|.|.  ...:::.
 Frog   911 NSTSVLSENQGHLENMMSPTHFSSVADWQTNQPA---------GAVPMYNPLQFPS--DGKTVSN 964

Human  1049 PNRLAQRRYPTQP 1061
            ||.|.:.|||.||
 Frog   965 PNCLIRGRYPVQP 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC16B	NP_001377763.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		26/87 (30%)
		Required for endoplasmic reticulum localization	34..224		47/210 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..236		16/79 (20%)
		Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000269|PubMed:21768384	272..714		260/453 (57%)
		ACE1-Sec16-like	328..684	CDD:187750	212/356 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..734		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..797		5/27 (19%)
sec16b	XP_031756826.1	ACE1-Sec16-like	293..646	CDD:187750	212/356 (60%)