DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIGLEC12 and CG45263

DIOPT Version :10

Sequence 1:NP_443729.1 Gene:SIGLEC12 / 89858 HGNCID:15482 Length:595 Species:Homo sapiens
Sequence 2:NP_731246.2 Gene:CG45263 / 50003 FlyBaseID:FBgn0266801 Length:1876 Species:Drosophila melanogaster


Alignment Length:760 Identity:147/760 - (19%)
Similarity:230/760 - (30%) Gaps:286/760 - (37%)


- Green bases have known domain annotations that are detailed below.


Human     2 LLLLLLLPPLLC--GRVGAK---EQ---------KDYLLTMQKSVTVQEGLCVSVLCSFSYPQNG 52
            ||||:.:....|  |..|.:   ||         :|.|||.:  |..:.|.|            .
  Fly    33 LLLLIGIAVASCLPGSEGFQRFSEQPKYTEVNPAEDTLLTCK--VIDKRGTC------------S 83

Human    53 WTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHL-LGDPQ---NKDCTLSIRD-TR 112
            |...:...|.:.:..:..|| :|.:.|.          :..|| |..|.   ..||:|.||. |.
  Fly    84 WQKDNKPVGIYTKKYEWASR-MPTSDNG----------NVLHLDLHPPPVQLGGDCSLWIRSATL 137

Human   113 ESDAGTYVFCVERGNMKWNYKYDQLSVNVTAS----QDLLS-------------RYRLE-----V 155
            :.|.|.:                  ...||||    ||.|:             |.|||     |
  Fly   138 DFDDGLW------------------ECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHV 184

Human   156 P--ESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADI----------------PWDIP 202
            |  .::|...|...:|.|   ..||   .:.|....||....:|                .|.  
  Fly   185 PPGHNITADAGALATVKC---ISHY---GNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWS-- 241

Human   203 VATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVH 267
             ||:........:.||..|        .|:                       .::..|...||.
  Fly   242 -ATSVVQVSAMRERHGDIL--------RCA-----------------------AYHESYTAKSVV 274

Human   268 VTA---LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPP-TITWMGA---SVSSLDPTITRSS 325
            |.|   :.:.|:..:.|:.|.....:....|........|| :|.|..|   .::||..|     
  Fly   275 VEARLDVKYAPSIRLIGSPEIDLEEDKDALVLRCVADANPPASIVWRRAGRSEIASLQET----- 334

Human   326 MLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQ------------------------ 366
             |.|.|..:......|||.. ...|.:...:|:|::.|||:                        
  Fly   335 -LQLRPVGRRDAGLYTCQAQ-NSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLA 397

Human   367 --------------------------------NLTMTVFQGD-GTASTTLRNGS----------- 387
                                            |:|.. :||: ...:|:..||.           
  Fly   398 DGNPLPSFKWVQRMAHGSKYVERGSESRLVIDNVTYE-YQGEYECRATSYINGQERVAISDPVSL 461

Human   388 ----------------ALSVLEGQSLHLVCAVDSNP-PARLSWTWGSLTLSPS------------ 423
                            .:||..|::..|...|.::| |.|::|.||||.|...            
  Fly   462 QVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQ 526

Human   424 ----QSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPIS-GVTLGAFG 483
                :...|..|.:......|...:....:|..|:...::.|.::..:.   .|.. ...:|..|
  Fly   527 PDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDRHAIHLIVEGTFA---EPYEMSYLMGVAG 588

Human   484 GAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDAN--------AVRGSASQGP----L 536
            |..|..|:.:..||..:..:.|..|        |.||.:.::        ..|..::.||    :
  Fly   589 GCMAAILLLVCLCIYAIKSKRCCFK--------GSTGYKSSDKDSEKADLKSRSDSTSGPQGDSI 645

Human   537 IESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQ 581
            ..:||..   ||..........::.....|:.:.| |..|:||:|
  Fly   646 YTTPAGF---HHHQQQQQQQQQQQHAAAAAAAALH-AASQHPQQQ 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGLEC12NP_443729.1 IgV_CD33 24..142 CDD:409377 24/122 (20%)
FR1 24..48 CDD:409377 6/23 (26%)
Ig strand A 24..28 CDD:409377 2/3 (67%)
Ig strand A' 31..35 CDD:409377 1/3 (33%)
Ig strand B 37..48 CDD:409377 2/10 (20%)
CDR1 49..58 CDD:409377 1/8 (13%)
FR2 59..66 CDD:409377 1/6 (17%)
Ig strand C 59..66 CDD:409377 1/6 (17%)
CDR2 67..90 CDD:409377 4/22 (18%)
Ig strand C' 77..80 CDD:409377 0/2 (0%)
FR3 91..124 CDD:409377 12/37 (32%)
Ig strand D 92..96 CDD:409377 2/4 (50%)
Ig strand E 102..110 CDD:409377 4/7 (57%)
Ig strand F 117..125 CDD:409377 1/7 (14%)
CDR3 125..128 CDD:409377 0/2 (0%)
FR4 129..142 CDD:409377 0/12 (0%)
Ig strand G 129..142 CDD:409377 0/12 (0%)
Ig 151..269 CDD:472250 25/140 (18%)
Ig strand B 167..171 CDD:409377 1/3 (33%)
Ig strand C 187..191 CDD:409377 0/3 (0%)
Ig strand E 231..235 CDD:409377 1/3 (33%)
Ig strand F 245..250 CDD:409377 0/4 (0%)
Ig strand G 258..264 CDD:409377 1/5 (20%)
Ig 275..360 CDD:472250 20/88 (23%)
Ig strand B 289..293 CDD:409579 0/3 (0%)
Ig strand C 306..310 CDD:409579 1/3 (33%)
Ig strand E 325..329 CDD:409579 1/3 (33%)
Ig strand F 339..344 CDD:409579 2/4 (50%)
Ig strand G 354..357 CDD:409579 0/2 (0%)
Ig 386..464 CDD:472250 21/121 (17%)
Ig strand B 397..401 CDD:409540 1/3 (33%)
Ig strand C 410..414 CDD:409540 1/3 (33%)
Ig strand E 432..436 CDD:409540 0/3 (0%)
Ig strand F 443..448 CDD:409540 0/4 (0%)
Ig strand G 458..461 CDD:409540 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..560 10/59 (17%)
ITIM motif 563..568 1/4 (25%)
SLAM-like motif 586..591
CG45263NP_731246.2 Ig 170..281 CDD:472250 28/150 (19%)
Ig strand B 198..202 CDD:409353 1/3 (33%)
Ig strand C 212..216 CDD:409353 0/3 (0%)
Ig strand E 244..248 CDD:409353 0/3 (0%)
Ig strand F 258..263 CDD:409353 2/35 (6%)
Ig strand G 274..277 CDD:409353 1/2 (50%)
Ig 304..364 CDD:409353 16/66 (24%)
Ig strand B 304..308 CDD:409353 1/3 (33%)
Ig strand C 317..321 CDD:409353 1/3 (33%)
Ig strand E 334..337 CDD:409353 2/8 (25%)
Ig strand F 347..352 CDD:409353 2/4 (50%)
Ig strand G 361..364 CDD:409353 0/2 (0%)
Ig_3 371..444 CDD:464046 6/73 (8%)
Ig 475..568 CDD:472250 19/92 (21%)
Ig strand B 487..491 CDD:409353 1/3 (33%)
Ig strand C 501..505 CDD:409353 1/3 (33%)
Ig strand E 536..540 CDD:409353 1/3 (33%)
Ig strand F 550..555 CDD:409353 0/4 (0%)
Ig strand G 563..566 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

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