DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIGLEC12 and CG45263

DIOPT Version :9

Sequence 1:NP_443729.1 Gene:SIGLEC12 / 89858 HGNCID:15482 Length:595 Species:Homo sapiens
Sequence 2:NP_731246.2 Gene:CG45263 / 50003 FlyBaseID:FBgn0266801 Length:1876 Species:Drosophila melanogaster


Alignment Length:760 Identity:147/760 - (19%)
Similarity:230/760 - (30%) Gaps:286/760 - (37%)


- Green bases have known domain annotations that are detailed below.


Human     2 LLLLLLLPPLLC--GRVGAK---EQ---------KDYLLTMQKSVTVQEGLCVSVLCSFSYPQNG 52
            ||||:.:....|  |..|.:   ||         :|.|||.:  |..:.|.|            .
  Fly    33 LLLLIGIAVASCLPGSEGFQRFSEQPKYTEVNPAEDTLLTCK--VIDKRGTC------------S 83

Human    53 WTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHL-LGDPQ---NKDCTLSIRD-TR 112
            |...:...|.:.:..:..|| :|.:.|.          :..|| |..|.   ..||:|.||. |.
  Fly    84 WQKDNKPVGIYTKKYEWASR-MPTSDNG----------NVLHLDLHPPPVQLGGDCSLWIRSATL 137

Human   113 ESDAGTYVFCVERGNMKWNYKYDQLSVNVTAS----QDLLS-------------RYRLE-----V 155
            :.|.|.:                  ...||||    ||.|:             |.|||     |
  Fly   138 DFDDGLW------------------ECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHV 184

Human   156 P--ESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADI----------------PWDIP 202
            |  .::|...|...:|.|   ..||   .:.|....||....:|                .|.  
  Fly   185 PPGHNITADAGALATVKC---ISHY---GNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWS-- 241

Human   203 VATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVH 267
             ||:........:.||..|        .|:                       .::..|...||.
  Fly   242 -ATSVVQVSAMRERHGDIL--------RCA-----------------------AYHESYTAKSVV 274

Human   268 VTA---LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPP-TITWMGA---SVSSLDPTITRSS 325
            |.|   :.:.|:..:.|:.|.....:....|........|| :|.|..|   .::||..|     
  Fly   275 VEARLDVKYAPSIRLIGSPEIDLEEDKDALVLRCVADANPPASIVWRRAGRSEIASLQET----- 334

Human   326 MLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQ------------------------ 366
             |.|.|..:......|||.. ...|.:...:|:|::.|||:                        
  Fly   335 -LQLRPVGRRDAGLYTCQAQ-NSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLA 397

Human   367 --------------------------------NLTMTVFQGD-GTASTTLRNGS----------- 387
                                            |:|.. :||: ...:|:..||.           
  Fly   398 DGNPLPSFKWVQRMAHGSKYVERGSESRLVIDNVTYE-YQGEYECRATSYINGQERVAISDPVSL 461

Human   388 ----------------ALSVLEGQSLHLVCAVDSNP-PARLSWTWGSLTLSPS------------ 423
                            .:||..|::..|...|.::| |.|::|.||||.|...            
  Fly   462 QVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQ 526

Human   424 ----QSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPIS-GVTLGAFG 483
                :...|..|.:......|...:....:|..|:...::.|.::..:.   .|.. ...:|..|
  Fly   527 PDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDRHAIHLIVEGTFA---EPYEMSYLMGVAG 588

Human   484 GAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDAN--------AVRGSASQGP----L 536
            |..|..|:.:..||..:..:.|..|        |.||.:.::        ..|..::.||    :
  Fly   589 GCMAAILLLVCLCIYAIKSKRCCFK--------GSTGYKSSDKDSEKADLKSRSDSTSGPQGDSI 645

Human   537 IESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQ 581
            ..:||..   ||..........::.....|:.:.| |..|:||:|
  Fly   646 YTTPAGF---HHHQQQQQQQQQQQHAAAAAAAALH-AASQHPQQQ 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGLEC12NP_443729.1 Ig 24..142 CDD:325142 24/122 (20%)
Ig 151..269 CDD:325142 25/140 (18%)
Ig 232..345 CDD:325142 23/119 (19%)
IG_like 389..462 CDD:214653 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..560 10/59 (17%)
ITIM motif 563..568 1/4 (25%)
SLAM-like motif 586..591
CG45263NP_731246.2 I-set 53..149 CDD:254352 27/138 (20%)
Ig 198..281 CDD:299845 20/122 (16%)
IG_like 302..368 CDD:214653 18/72 (25%)
IGc2 302..357 CDD:197706 15/61 (25%)
Ig 372..446 CDD:299845 6/74 (8%)
Ig 475..568 CDD:299845 19/92 (21%)
IG_like 478..570 CDD:214653 20/91 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11775
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X34
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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