DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC12 and him-4

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	112/480 - (23%)
Similarity:	169/480 - (35%)	Gaps:	142/480 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     6 LLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGD-- 68
            :|:||.:           .:|...|:.|..|...|::.|    |..|....|..   ||:.|:
Worm  2283 VLVPPTI-----------IMLDKDKNKTAVEHSTVTLSC----PATGKPEPDIT---WFKDGEAI 2329

Human    69 HVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYK 133
            |:.....:..|......|                   |.|...:|.|||.|. | |..|...:.:
Worm  2330 HIENIADIIPNGELNGNQ-------------------LKITRIKEGDAGKYT-C-EADNSAGSVE 2373

Human   134 YDQLSVNVTASQDLLSRYRLE---VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGA 195
            .|   |||    ::::..::|   :|.....|:...|.:.|.|.       |..|...:|.|.|.
Worm  2374 QD---VNV----NVITIPKIEKDGIPSDYESQQNERVVISCPVY-------ARPPAKITWLKAGK 2424

Human   196 DIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKY--YFQVERGSRKWN 258
            .:..|..|.|:                     .|...|.:...|:.||.||  ....|.|:.|.:
Worm  2425 PLQSDKFVKTS---------------------ANGQKLYLFKLRETDSSKYTCIATNEAGTDKRD 2468

Human   259 YIYDKLSVHVTALTHMPTFSIPG-----TLESGHPRNLTCSVPWACEQGTP-PTITWM--GASVS 315
            :   |:|:.|.     |:|..|.     |:.||:|..|.|..     :|:| |||||:  |.::.
Worm  2469 F---KVSMLVA-----PSFDEPNIVRRITVNSGNPSTLHCPA-----KGSPSPTITWLKDGNAIE 2520

Human   316 SLDPTI----TRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGD 376
            ..|..:    .|...:|. .:..|.| ..||..|.......:...  |.:..||      |..|:
Worm  2521 PNDRYVFFDAGRQLQISK-TEGSDQG-RYTCIATNSVGSDDLENT--LEVIIPP------VIDGE 2575

Human   377 GTASTTLRNGSALSVLEGQSLHLVCAVDSNPP-ARLSWTWGSLTLS------------PSQSSNL 428
                    ...|::|:||.|..|.|  |||.. ..:.|....||::            ||....:
Worm  2576 --------RREAVAVIEGFSSELFC--DSNSTGVDVEWQKDGLTINQDTLRGDSFIQIPSSGKKM 2630

Human   429 GVLELPRVHVKDEGEFTCRAQNPLG 453
            ..|...:   .|.|.:||..:||.|
Worm  2631 SFLSARK---SDSGRYTCIVRNPAG 2652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142	28/119 (24%)
		Ig	151..269	CDD:325142	26/122 (21%)
		Ig	232..345	CDD:325142	36/126 (29%)
		IG_like	389..462	CDD:214653	22/78 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652
		Ig	628..694	CDD:319273
		I-set	702..789	CDD:369462
		I-set	793..881	CDD:369462
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229
		IGc2	1563..1628	CDD:197706
		Ig	1651..1732	CDD:386229
		Ig	1755..1818	CDD:319273
		Ig	1839..1912	CDD:386229
		Ig	1930..2002	CDD:386229
		IG_like	2014..2095	CDD:214653
		Ig	2094..2182	CDD:386229
		Ig	2190..2283	CDD:386229	112/480 (23%)
		I-set	2296..2380	CDD:369462	28/118 (24%)
		Ig	2384..2471	CDD:386229	24/117 (21%)
		IGc2	2492..2556	CDD:197706	21/70 (30%)
		Ig	2580..2654	CDD:386229	22/78 (28%)
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653
		I-set	3046..3116	CDD:369462
		I-set	3127..3213	CDD:369462
		Ig	3217..3292	CDD:386229
		I-set	3300..3386	CDD:369462
		I-set	3396..3472	CDD:369462
		I-set	3481..3569	CDD:369462
		I-set	3591..3663	CDD:369462
		Ig	3667..3762	CDD:386229
		Ig	3775..3848	CDD:386229
		Ig	3859..3947	CDD:386229
		IGc2	3968..4031	CDD:197706
		Ig_3	4045..4119	CDD:372822
		Ig_3	4136..4210	CDD:372822
		Ig	<4262..4314	CDD:386229
		Ig	4318..4406	CDD:386229
		IG_like	4418..4496	CDD:214653
		I-set	4570..4654	CDD:369462
		I-set	4752..4836	CDD:369462
		EGF_CA	4996..5027	CDD:238011
		EGF_CA	5034..5076	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910