DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC12 and wrk-1

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	51/245 - (20%)
Similarity:	81/245 - (33%)	Gaps:	53/245 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   379 ASTTLR---NGSALSVLEGQSLHLVCAVDSNPPARLSW---------------TWGSLTLSPSQS 425
            |||:.:   .|..|...||:||.|.|.|: :|...:.|               |:|...:|...|
Worm    14 ASTSAQIRTKGGTLIAKEGESLTLRCEVE-DPSVAIIWRKNTEVVAVDDEILDTYGGYEISMEGS 77

Human   426 SNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPI------SGVTLGAFGG 484
            ::  ||.:.||...:...::|....|..|....:.:.:.......::|:      :||.....|.
Worm    78 TS--VLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVFKPTQVSVKPLVVISPDTGVYHARVGE 140

Human   485 AGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGM-----EDANAVRGSASQGPLIESPADDS 544
            ..              :|.:|..|...|..||..|..     ||.....|.|      .....:.
Worm   141 KN--------------LVITCHVKEGNPKPGVVWTKQAAKLPEDIKREHGGA------RIVITEV 185

Human   545 PPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIP 594
            ..|||...........|. ..|::..|.|.|...:.:|....:..:..||
Worm   186 KKHHAGKYNCLAENIAGS-DRATIDIHVAEPLQGEREEKPWVKNEDTFIP 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142
		Ig	151..269	CDD:325142
		Ig	232..345	CDD:325142
		IG_like	389..462	CDD:214653	21/87 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560		11/52 (21%)
		ITIM motif	563..568		1/4 (25%)
		SLAM-like motif	586..591		0/4 (0%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	21/90 (23%)
		IGc2	31..96	CDD:197706	17/67 (25%)
		IG_like	132..212	CDD:214653	19/100 (19%)
		IGc2	142..202	CDD:197706	14/79 (18%)
		IG_like	235..320	CDD:214653	51/245 (21%)
		Ig	245..318	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000