DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC12 and igcm-4

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_508377.1	Gene:	igcm-4 / 180518	WormBaseID:	WBGene00022418	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	81/447 - (18%)
Similarity:	143/447 - (31%)	Gaps:	125/447 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   190 WFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERG- 253
            |.|.|..:.||       ...|:.:|:.              .|.::..:..|||:|..|...|
Worm    70 WSKNGEQLDWD-------SQYKLSKDSK--------------ELKMKSVKFEDSGRYQCQATNGF 113

Human   254 --------------SRKWNYIYDKLSVHVTALTHMPTFSI--------PGTLESGHPRNLTCSVP 296
                          ..|.|.:.|.|.:..|  |..|::.|        |..:.:|....|.|..
Worm   114 GHKTIEFIVHVHDQHDKENSVKDYLVLSNT--TASPSWLIDMNSEWRSPIKINTGGKLELRCPA- 175

Human   297 WACEQGTP-PTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLN 360
                ||.| |.|.|....:...:.|....|.:::.|....|.....|.|..|...::....|.:.
Worm   176 ----QGNPLPEIRWYQNEMEISEKTHKHVSTITVEPVESSHSGVYRCVVENPLGSLSFAFDVSVG 236

Human   361 ISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW---------- 415
            ..:.|.....|.:| :......:.....:||..|.:....|.|.||....:.|..
Worm   237 DFFDPTTTEATEYQ-ETAMEPVIDQPYNISVYAGHTAQFQCKVKSNENTIIKWLKEVSDPLSIRR 300

Human   416 --GSLTLSPSQSSNLGVLE-------LPR------------VHVKD---EGEFTC---RAQNPLG 453
              .:.|:......||.||:       ||:            :|..|   .|::.|   .||..:.
Worm   301 KDPNSTVIHVNGMNLLVLDHIQTESSLPQEDMDNIYTNRLTIHKVDYHHAGKYICVVTSAQGQIV 365

Human   454 SQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGD 518
            .:...|.:....::|...:....:.|.|       .:|.|:..::.:.:...:|..
Worm   366 YKSAELKVLSAYDFTFPFKSDGFLVLLA-------VVVTLFIFVVILAIIWLKKNQ--------- 414

Human   519 TGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARP 575
                       .::.|..::.|   .||...|||    :|::.:.. :..:.|.::|
Worm   415 -----------ESTSGKDLKPP---PPPRMPPPA----APQDNDWS-SDRTLHSSKP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142
		Ig	151..269	CDD:325142	18/93 (19%)
		Ig	232..345	CDD:325142	30/136 (22%)
		IG_like	389..462	CDD:214653	22/109 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560		8/47 (17%)
		ITIM motif	563..568		0/4 (0%)
		SLAM-like motif	586..591
igcm-4	NP_508377.1	IGc2	52..114	CDD:197706	14/64 (22%)
		I-set	159..235	CDD:254352	18/80 (23%)
		IGc2	166..225	CDD:197706	16/63 (25%)
		IG_like	261..373	CDD:214653	22/111 (20%)
		Ig	269..374	CDD:299845	20/104 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910