DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC12 and sma-10

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	401	Identity:	70/401 - (17%)
Similarity:	119/401 - (29%)	Gaps:	167/401 - (41%)

- Green bases have known domain annotations that are detailed below.

Human   219 RFLLLGD-PQTNNCSLSIRDARKGDSGKYYF------------QVERGSRKWNY----------I 260
            |||.... |...|.||:..|..:.|.|.:|.            :|:..:..|.:          .
Worm   235 RFLAFNQLPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLDLS 299

Human   261 YDKL-SVHVTALTHMP----------------------------------------TFSIPGTLE 284
            |::: |.|:::.:|.|                                        .|::.| :.
Worm   300 YNQIQSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDSLHKFALVG-MS 363

Human   285 SGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRS-----SMLSLIPQ------PQDHGT 338
            |.|..:|:.:....|.:.        ||.:.:......||     :.|.:||:      |.....
Worm   364 SLHKLDLSSNTLAVCVED--------GAVLYNTSMPFLRSLRFTNNQLRVIPKRAFERFPALEEL 420

Human   339 SLT------------------------------CQVTLPGAGVTMTRAVRLNI----SYPPQNLT 369
            .||                              ||::...:.:...:..:.:|    ||||....
Worm   421 DLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIAKCSYPPPLAD 485

Human   370 MTVFQGDGTASTTLRNGS----------ALSVLEGQSLHLVCAVDSNPPARLSW----------- 413
            :.|...| ||:.|..|.|          .:|.|.|:.....|.|....|..:.|
Worm   486 LYVVAID-TANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQPRVL 549

Human   414 ------------------TWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQ---HI 457
                              |:....|:.::      |.|..|.:.|..|:.|.|:|..||.   |:
Worm   550 VQDSATFLSINRTAVVNGTFDERELAAAE------LLLDNVAMTDNSEYQCVARNRFGSDFSTHV 608

Human   458 SLSLSLQNEYT 468
            .|.:....::|
Worm   609 KLQVYQAPKFT 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142
		Ig	151..269	CDD:325142	16/73 (22%)
		Ig	232..345	CDD:325142	31/216 (14%)
		IG_like	389..462	CDD:214653	21/104 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064	14/67 (21%)
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380	3/8 (38%)
		LRR_8	243..303	CDD:290566	11/59 (19%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRR_RI	269..453	CDD:238064	23/192 (12%)
		leucine-rich repeat	269..292	CDD:275380	2/22 (9%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		LRR_8	315..373	CDD:290566	6/58 (10%)
		leucine-rich repeat	317..340	CDD:275380	0/22 (0%)
		leucine-rich repeat	341..364	CDD:275380	2/23 (9%)
		leucine-rich repeat	365..392	CDD:275380	5/34 (15%)
		LRR_8	393..450	CDD:290566	8/56 (14%)
		leucine-rich repeat	393..416	CDD:275380	5/22 (23%)
		leucine-rich repeat	417..438	CDD:275380	2/20 (10%)
		I-set	506..612	CDD:254352	21/111 (19%)
		Ig	522..606	CDD:143165	16/89 (18%)
		I-set	616..705	CDD:254352	1/4 (25%)
		Ig	633..705	CDD:299845
		Ig	716..786	CDD:299845
		IG	719..788	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910