DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIGLEC12 and si:ch211-1f22.3

DIOPT Version :10

Sequence 1:NP_443729.1 Gene:SIGLEC12 / 89858 HGNCID:15482 Length:595 Species:Homo sapiens
Sequence 2:XP_073763170.1 Gene:si:ch211-1f22.3 / 100148240 ZFINID:ZDB-GENE-121214-89 Length:520 Species:Danio rerio


Alignment Length:610 Identity:147/610 - (24%)
Similarity:238/610 - (39%) Gaps:155/610 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLLLLLLLPP------LLCGRVGAKEQKDYLLT-MQKSVTVQEGLCVSVLCSFSYPQNGWTASDP 58
            ||:.|.:.|.      |:..||.:   .|:.:. :...:...:...|.:.|:|:||    |....
Zfish     1 MLMWLRMAPALHLIFLLIIHRVSS---ADWAVNYIHSRICALKNSSVIMSCTFTYP----TRHQI 58

Human    59 VHGYWFRAGDHVSRNIPV-ATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYV-- 120
            ...:|.:  |:|....|. .:.:|      |...|...|||.| ::||:.:....:.|...|.  
Zfish    59 KKVFWTK--DNVKDIEPTDLSKDP------EYSQRLQYLGDKQ-QNCTVRLSHVTKKDEHQYYFR 114

Human   121 FCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSP 185
            |.....|.||..| ..:.::||   ||    :||.||.||  ||..|.:.|:....    ...:|
Zfish   115 FITNVPNEKWTGK-PGVHLSVT---DL----QLESPERVT--EGDSVRLTCNSSCK----LTDTP 165

Human   186 VYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQV 250
            .: .|::.               |..:.|.|.|..|:|         :|.|:..   :|:|...|
Zfish   166 TF-IWYRN---------------SHTLTEGTTGDKLIL---------ISFREEY---AGRYRCAV 202

Human   251 ERGSRK-----WNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWM 310
            :..:..     .|..|...||.|       |.|....:.||....|:||    .:...|..|.|.
Zfish   203 DGHTLTSPEVYLNVTYPPKSVSV-------TISGSAVIMSGDSVTLSCS----SDSNPPAEIHWF 256

Human   311 GASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQG 375
            ..     :..:....:|::.....|......|:.. ...||..:.||.||:.|||:||::|:   
Zfish   257 KG-----ETFVGSGRILNISKISSDDSKKYKCKAK-NDHGVKYSAAVTLNVQYPPRNLSVTI--- 312

Human   376 DGTASTTLRNGSALSVLE-GQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVK 439
                     :|||  |:| |.|:.|:|..|||||| ||::|    ...:|||.:|..:  .....
Zfish   313 ---------SGSA--VIEYGDSVGLMCISDSNPPA-LSFSW----FKENQSSAVGSGQ--SFSAV 359

Human   440 DEGEFTCRAQNPLGSQH---ISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVV 501
            ..|.|.|.|.||.|:|.   :::::....|     |.|..:.....||        |:..||.::
Zfish   360 QSGRFYCEAHNPHGAQRSDAVTVTVHQHAE-----RNIIIIITATSGG--------LFIIIIIII 411

Human   502 VRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEG----- 561
            :...:|:.:....|:..| ..|.::..|||...                 ..|:.:|::|     
Zfish   412 LCLIKKQRSVKCEGLTLT-QNDLHSAPGSAGDA-----------------LYASVNPKKGRAAEC 458

Human   562 ----EIQYASLSFHKARPQYPQEQE 582
                |||||::.:|:......:|:|
Zfish   459 RDAEEIQYATVQYHRDTQMKREEEE 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGLEC12NP_443729.1 IgV_CD33 24..142 CDD:409377 26/121 (21%)
FR1 24..48 CDD:409377 3/24 (13%)
Ig strand A 24..28 CDD:409377 0/4 (0%)
Ig strand A' 31..35 CDD:409377 0/3 (0%)
Ig strand B 37..48 CDD:409377 3/10 (30%)
CDR1 49..58 CDD:409377 2/8 (25%)
FR2 59..66 CDD:409377 1/6 (17%)
Ig strand C 59..66 CDD:409377 1/6 (17%)
CDR2 67..90 CDD:409377 5/23 (22%)
Ig strand C' 77..80 CDD:409377 0/2 (0%)
FR3 91..124 CDD:409377 10/34 (29%)
Ig strand D 92..96 CDD:409377 1/3 (33%)
Ig strand E 102..110 CDD:409377 2/7 (29%)
Ig strand F 117..125 CDD:409377 2/9 (22%)
CDR3 125..128 CDD:409377 0/2 (0%)
FR4 129..142 CDD:409377 3/12 (25%)
Ig strand G 129..142 CDD:409377 3/12 (25%)
Ig 151..269 CDD:472250 27/122 (22%)
Ig strand B 167..171 CDD:409377 1/3 (33%)
Ig strand C 187..191 CDD:409377 0/3 (0%)
Ig strand E 231..235 CDD:409377 0/3 (0%)
Ig strand F 245..250 CDD:409377 1/4 (25%)
Ig strand G 258..264 CDD:409377 2/5 (40%)
Ig 275..360 CDD:472250 17/84 (20%)
Ig strand B 289..293 CDD:409579 1/3 (33%)
Ig strand C 306..310 CDD:409579 1/3 (33%)
Ig strand E 325..329 CDD:409579 1/3 (33%)
Ig strand F 339..344 CDD:409579 1/4 (25%)
Ig strand G 354..357 CDD:409579 0/2 (0%)
Ig 386..464 CDD:472250 30/81 (37%)
Ig strand B 397..401 CDD:409540 1/3 (33%)
Ig strand C 410..414 CDD:409540 2/3 (67%)
Ig strand E 432..436 CDD:409540 0/3 (0%)
Ig strand F 443..448 CDD:409540 2/4 (50%)
Ig strand G 458..461 CDD:409540 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..560 8/47 (17%)
ITIM motif 563..568 4/4 (100%)
SLAM-like motif 586..591
si:ch211-1f22.3XP_073763170.1 None
Blue background indicates that the domain is not in the aligned region.

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