DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC12 and si:ch211-1f22.3

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	XP_021333796.1	Gene:	si:ch211-1f22.3 / 100148240	ZFINID:	ZDB-GENE-121214-89	Length:	290	Species:	Danio rerio

Alignment Length:	307	Identity:	81/307 - (26%)
Similarity:	140/307 - (45%)	Gaps:	51/307 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   167 VSVPCSVLYPHYNWTASSPVYGSWFKEGA-DI-PWDIPVATNTPSGKVQEDTHGRFLLLGDPQTN 229
            |.:.|:..||    |........|.|:.. || |.|:   :..|      :...|...|||.| .
Zfish    25 VIMSCTFTYP----TRHQIKKVFWTKDNVKDIEPTDL---SKDP------EYSQRLQYLGDKQ-Q 75

Human   230 NCSLSIRDARKGDSGKYYFQ--VERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLT 292
            ||::.:....|.|..:|||:  ....:.||.   .|..||: ::|.:...| |..:..|....||
Zfish    76 NCTVRLSHVTKKDEHQYYFRFITNVPNEKWT---GKPGVHL-SVTDLQLES-PERVTEGDSVRLT 135

Human   293 CSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTR-A 356
            |:.  :|:....||..|...|.:..:.  |....|.||...:::.....|.|.    |.|:|. .
Zfish   136 CNS--SCKLTDTPTFIWYRNSHTLTEG--TTGDKLILISFREEYAGRYRCAVD----GHTLTSPE 192

Human   357 VRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLS 421
            |.||::|||:::::|:            :|||: ::.|.|:.|.|:.||||||.:.|..|...:.
Zfish   193 VYLNVTYPPKSVSVTI------------SGSAV-IMSGDSVTLSCSSDSNPPAEIHWFKGETFVG 244

Human   422 PSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQH-ISLSLSLQNEY 467
            ..:     :|.:.::...|..::.|:|:|..|.:: .:::|::|.|:
Zfish   245 SGR-----ILNISKISSDDSKKYKCKAKNDHGVKYSAAVTLNVQCEF 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142
		Ig	151..269	CDD:325142	29/105 (28%)
		Ig	232..345	CDD:325142	27/114 (24%)
		IG_like	389..462	CDD:214653	18/73 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591
si:ch211-1f22.3	XP_021333796.1	Ig	15..106	CDD:325142	25/94 (27%)
		IG	122..197	CDD:214652	22/83 (27%)
		Ig_2	211..282	CDD:316418	21/76 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I34796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910