DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC12 and si:ch211-286b5.9

DIOPT Version :9

Sequence 1:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens
Sequence 2:	XP_017211393.1	Gene:	si:ch211-286b5.9 / 100003869	ZFINID:	ZDB-GENE-121214-63	Length:	347	Species:	Danio rerio

Alignment Length:	394	Identity:	93/394 - (23%)
Similarity:	160/394 - (40%)	Gaps:	93/394 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   129 KWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKE 193
            ||..||.::::....|.      .:.:..|.|...||.|:        ...||. :|..|.
Zfish    20 KWGVKYSKMAICALKSS------TIHLSGSYTHPYGLTVT--------KIFWTV-NPKIGE---- 65

Human   194 GADIPWDIPVATNTP-SGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKW 257
                  .|.:..|:. :|:|:.....:|..          :.:.:.|:.|.|.|..::|....|.
Zfish    66 ------SINLLDNSNYTGRVEYFDKDKFFF----------VKLSNVRQEDEGMYCLRIETKVEKE 114

Human   258 NYI-YDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWM--GASVSSLDP 319
            .:: |..:.:.||.|    ....|..:..|....|.|..  :|..|: ...:|.  |.|.|.
Zfish   115 RHLGYPGIELTVTEL----RVETPEEVVEGDSPVLICKS--SCNLGS-TNFSWYKNGESFSK--- 169

Human   320 TITRSSMLSLIPQPQDHGTSLTCQV----TLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTAS 380
            .:..:.::......:|.| :.:|.|    .||...:|      ||:.|||::::::|
Zfish   170 WVGENQLILQSVSREDSG-NYSCAVRDLKDLPSPALT------LNVRYPPKSVSVSV-------- 219

Human   381 TTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLG---VLELPRVHVKDEG 442
                :|||: ::.|.|:.|.|:.|||||| |:::|    ...:|||.:|   ...:...:....|
Zfish   220 ----SGSAV-IVSGDSVTLSCSSDSNPPA-LNFSW----FKENQSSAIGSGQSFSISSFNTNHSG 274

Human   443 EFTCRAQNPLGS-QHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCR 506
            .:.|.|.|..|| :..|:||:.::.        ....|.|..|.||   .|:..|||.|.::..|
Zfish   275 RYYCEAHNKYGSLRSASVSLTAKDG--------QNTLLYAAAGFGA---AFICICIIIVALKIIR 328

Human   507 KKSA 510
            :|:|
Zfish   329 RKTA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142	4/12 (33%)
		Ig	151..269	CDD:325142	21/119 (18%)
		Ig	232..345	CDD:325142	24/119 (20%)
		IG_like	389..462	CDD:214653	24/76 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591
si:ch211-286b5.9	XP_017211393.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I34796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910