Protein Alignment PLOD3 and Plod

DIOPT Version :10

• Sequence 1: NP_001075.1
• Gene: PLOD3 / 8985
• HGNCID: 9083
• Length: 738
• Species: Homo sapiens
• Sequence 2: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 332/733 - (45%)
• Similarity: 475/733 - (64%)
• Gaps: 26/733 - (3%)

Human    13 LLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRG 77
            ||.|||...:.........|     |:.|.||||..|:||.|::|||..::..|.||||||||:|
  Fly     8 LLLLLLAVTSQGDAESNWND-----KIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKG 67

Human    78 GDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAES 142
            ||:.:. |||.|:..|::.:..|.:..:.||:|.||||||:..:..|:.:||.:||:::|||||.
  Fly    68 GDMQKP-GGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEK 131

Human   143 FCWPEWGLAEQYPEV-GTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLRE 206
            :|||:..||..|||| |...||||||.|||:|..:..::.. ..:|..||||::|:::||...|.
  Fly   132 YCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETKRA 195

Human   207 KLSLNLDHKSRIFQNLNGALDEVVLKFD--RNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYV 269
            ||.|.||.:||:||||:||.::|.||.|  .|:..::||.:.|.|.::||||.:|:.||..|||:
  Fly   196 KLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYL 260

Human   270 PNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHN 334
            ..  |..|.|..|.::...|.....|. :.||:.|.||.||..:||:.:..|:||.:::.|.:::
  Fly   261 AR--TFNGVCLLCQENLLDLEETNLPV-ISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYS 322

Human   335 NEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTN 399
            |..||:..|.....:....::..|.....:.|...:.|.:|:|..|.. :.::.|.:||||.:.:
  Fly   323 NVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLH-QSDYIFFVDADAHIDD 386

Human   400 LQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQA 464
            .:.||.|:..|::.:||:.|:|.:||||||||||...|||||.|||::|:|:.:|::|||:::..
  Fly   387 GEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSI 451

Human   465 YVIRG---DTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHL 526
            |:::.   |.:.        |...:.|||||.|:|.|:.|||::.||...||.|:....::|...
  Fly   452 YLVKKTAFDAIS--------FKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVT 508

Human   527 HPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWS 591
            .||.:.:|.|.:||.|:|||.|||..|.....::|||||||||.::|:..||:|||.||.:..||
  Fly   509 RPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWS 573

Human   592 GGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGY-HTKARAVMNFVVR 655
            .|.:.|:||.||||.|||.||||||||.|..:|:.|:.:|.|:.|..|.|| |...||:|||:||
  Fly   574 DGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVR 638

Human   656 YRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHE 720
            |||||||||||||||||:|:|:|:|..|:||:||||||:||:|.::..:|||.|:||||||||||
  Fly   639 YRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHE 703

Human   721 GLPTTWGTRYIMVSFVDP 738
            ||..|.||||||:||:||
  Fly   704 GLLVTNGTRYIMISFIDP 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLOD3	NP_001075.1	Required for glycosyltransferase activity. /evidence=ECO:0000269|PubMed:18298658, ECO:0000269|PubMed:30089812	25..290		116/267 (43%)
		GT_LH3	37..266	CDD:438558	108/231 (47%)
		Accessory region. /evidence=ECO:0000269|PubMed:30089812	295..520		80/227 (35%)
		P4Hc	573..736	CDD:214780	103/163 (63%)
		Important for dimerization. /evidence=ECO:0000269|PubMed:30089812	672..715		24/42 (57%)
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	109/236 (46%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	23/92 (25%)
		P4Hc	555..719	CDD:214780	103/163 (63%)