Protein Alignment ATG16L2 and Atg16l2

DIOPT Version :10

• Sequence 1: NP_203746.1
• Gene: ATG16L2 / 89849
• HGNCID: 25464
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_001178489.1
• Gene: Atg16l2 / 308865
• RGDID: 1311400
• Length: 623
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 509/624 - (81%)
• Similarity: 553/624 - (88%)
• Gaps: 8/624 - (1%)

Human     1 MAGPGV---PGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPN 62
            ||||..   |.||.|.|||||:||||.||||||||||||||||||||||||||.|||:||:.||.
  Rat     1 MAGPSAPCDPCAPVAAWKRHILRQLRHRDRTQKALFLELVPAYNHLLEKAELLAKFSEKLKSEPK 65

Human    63 SVTPTTHQGPWEE-SELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQ 126
            .|..|.||...|| |....|||.|..:|:||||:|::||:|||||||||||.|.|||.||:|:|:
  Rat    66 DVISTPHQDSREEASGTGPDQVSSPASLKVKWQQEKKGLQLVCGEMAYQVVRKSAALNTLQSQLE 130

Human   127 QRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDL 191
            :||.||.||:|.|.||:||||||::|:||.:|:|:.||.|||.||.....:||||||||||||||
  Rat   131 ERQGRLEALQACVVQLQEARAQQSRQLEERQAENSAQREAYETLREQAAHQEAALRRLQEEARDL 195

Human   192 LERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALA 256
            ||:||||||||||||||||||||||.||||||||||||||||||||.|:||.||.:|  ||:||.
  Rat   196 LEQLVQRKARAAAERNLRNERRERANQARVSQELKKAAKRTVSISEIPNTLEDGTKE--ETVALG 258

Human   257 P--EPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVC 319
            |  :||.||.::|||||||:|||||||||||.||||||||||||||||||:||..|||||.||||
  Rat   259 PAAKPEFLESDSCEKWKRPYRSASATSLTLSRCVDVVKGLLDFKKRRGHSVGGVSEQRYQSIPVC 323

Human   320 VAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSIT 384
            |:|::|::|||||||||||||||.|.||||||||||||||||||||||.||||||||||||||||
  Rat   324 VSAQIPSQAQDVLDAHLSEVNAVCFAPNSSLLATGGADRLIHLWNVVGGRLEANQTLEGAGGSIT 388

Human   385 SVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEW 449
            ||||||||.||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   389 SVDFDPSGSQVLAATYNQAAQLWKVGETQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEW 453

Human   450 DLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQ 514
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||:|||||
  Rat   454 DLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCIQVIPVQGRVTSLNLSHDQ 518

Human   515 LHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDT 579
            ||||||||||||||||||:||||||||||||||.||||||||||||||||.||.:|.||||||:|
  Rat   519 LHLLSCSRDNTLKVIDLRISNIRQVFRADGFKCSSDWTKAVFSPDRSYALVGSSNGTLYIWDVNT 583

Human   580 GKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
            ||||:.||||||.||||||||:||:|:|||||.||||||
  Rat   584 GKLETSLQGPHCTAVNAVAWCFSGNHVVSVDQVRKVVLW 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L2	NP_203746.1	WD40 repeat	505..543	CDD:293791	35/37 (95%)
		WD 6. /evidence=ECO:0000255	546..585		32/38 (84%)
		WD40 repeat	551..587	CDD:293791	28/35 (80%)
		WD 7. /evidence=ECO:0000255	589..619		25/30 (83%)
		ATG16	32..203	CDD:462536	115/171 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..78		10/21 (48%)
		SMC_N	<121..>295	CDD:481474	129/175 (74%)
		WD40	331..619	CDD:238121	267/288 (93%)
		WD 1. /evidence=ECO:0000255	334..373		35/38 (92%)
		WD40 repeat	341..378	CDD:293791	33/36 (92%)
		WD 2. /evidence=ECO:0000255	378..417		36/38 (95%)
		WD40 repeat	384..420	CDD:293791	33/35 (94%)
		WD 3. /evidence=ECO:0000255	420..454		33/33 (100%)
		WD40 repeat	425..461	CDD:293791	35/35 (100%)
		WD 4. /evidence=ECO:0000255	455..498		41/42 (98%)
		WD40 repeat	467..499	CDD:293791	30/31 (97%)
		WD 5. /evidence=ECO:0000255	500..539		36/38 (95%)
Atg16l2	NP_001178489.1	ATG16	35..207	CDD:462536	115/171 (67%)
		WD40	335..612	CDD:238121	256/276 (93%)
		WD40 repeat	345..382	CDD:293791	33/36 (92%)
		WD40 repeat	388..424	CDD:293791	33/35 (94%)
		WD40 repeat	429..465	CDD:293791	35/35 (100%)
		WD40 repeat	471..503	CDD:293791	30/31 (97%)
		WD40 repeat	509..547	CDD:293791	35/37 (95%)
		WD40 repeat	555..591	CDD:293791	28/35 (80%)
		WD40 repeat	598..622	CDD:293791	19/23 (83%)