Protein Alignment ATG16L2 and SPOM_SPCC126.01C

DIOPT Version :10

• Sequence 1: NP_203746.1
• Gene: ATG16L2 / 89849
• HGNCID: 25464
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_588444.2
• Gene: SPOM_SPCC126.01C / 2538691
• PomBaseID: SPCC126.01C
• Length: 369
• Species: Schizosaccharomyces pombe
• Alignment Length: 290
• Identity: 64/290 - (22%)
• Similarity: 104/290 - (35%)
• Gaps: 91/290 - (31%)

Human   268 EKWKRPFRSASATSLTLSHCVDVVKGLLDFKK------RRGHSIGGAPEQRYQIIPVCVAARLPT 326
            :||          :::...||:.:.|..|:.|      ..|..:.|:.:....:..|   :..|:
pombe   115 KKW----------NVSTGECVETLIGHTDYVKCLLLLEEEGLLLSGSTDASLIVWDV---SSQPS 166

Human   327 RAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVV---GSRLEANQTLEGAGGSITSVD- 387
            |....|..|...:..:...||:.:..|.|::..|..|::.   ||:||.    ||..|..::|.
pombe   167 RLLYKLTGHSRGIECITRQPNTDIFWTCGSESSIRCWHITKVGGSQLEE----EGFWGHQSNVYC 227

Human   388 --FDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
              |||          ..:..||                               |.|.|:||:||.
pombe   228 LLFDP----------QDSEALW-------------------------------TASADKTVREWS 251

Human   451 LGRAYCSRT-INVLSYCNDVV-CGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHD 513
            |.:.....| :.....|.||: ..|..|.:...|::||.||:          ..|.|..:...|.
pombe   252 LYQGIHEETRMEHPDVCTDVLTLADGNIATACRDEEIRVWDT----------TTGNVKDIYSGHY 306

Human   514 Q---------LHLLSCSRDNTLKVIDLRVS 534
            :         .:|:|.|.|.|::|.||..|
pombe   307 ESVTKILQWKSYLISSSLDQTIRVWDLEYS 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L2	NP_203746.1	WD40 repeat	505..543	CDD:293791	11/39 (28%)
		WD 6. /evidence=ECO:0000255	546..585
		WD40 repeat	551..587	CDD:293791
		WD 7. /evidence=ECO:0000255	589..619
		ATG16	32..203	CDD:462536
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..78
		SMC_N	<121..>295	CDD:481474	5/26 (19%)
		WD40	331..619	CDD:238121	52/221 (24%)
		WD 1. /evidence=ECO:0000255	334..373		11/41 (27%)
		WD40 repeat	341..378	CDD:293791	10/39 (26%)
		WD 2. /evidence=ECO:0000255	378..417		8/41 (20%)
		WD40 repeat	384..420	CDD:293791	6/38 (16%)
		WD 3. /evidence=ECO:0000255	420..454		8/33 (24%)
		WD40 repeat	425..461	CDD:293791	9/36 (25%)
		WD 4. /evidence=ECO:0000255	455..498		11/44 (25%)
		WD40 repeat	467..499	CDD:293791	9/32 (28%)
		WD 5. /evidence=ECO:0000255	500..539		12/44 (27%)
SPOM_SPCC126.01C	NP_588444.2	WD40	54..332	CDD:238121	61/284 (21%)
		WD40 repeat	89..130	CDD:293791	4/24 (17%)
		WD40 repeat	135..173	CDD:293791	6/40 (15%)
		WD40 repeat	180..217	CDD:293791	10/40 (25%)
		WD40 repeat	225..263	CDD:293791	15/78 (19%)
		WD40 repeat	271..307	CDD:293791	11/45 (24%)
		WD40 repeat	309..331	CDD:293791	5/21 (24%)