Protein Alignment ATG16L2 and atg-16.2

DIOPT Version :10

• Sequence 1: NP_203746.1
• Gene: ATG16L2 / 89849
• HGNCID: 25464
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_495299.2
• Gene: atg-16.2 / 174067
• WormBaseID: WBGene00019427
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 621
• Identity: 151/621 - (24%)
• Similarity: 275/621 - (44%)
• Gaps: 109/621 - (17%)

Human    14 WKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESEL 78
            ::..|:.:|..|:|.|:.:        ..:.:...|||   ::||....|.:.:.:...::.:..
 Worm     8 FRLEILNRLCKRERQQRCV--------KDMFKNYSLLD---EQLQQSHRSRSVSVNDEHFKGNVN 61

Human    79 D-----SDQVPSLVALRVKWQEE--EEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALE 136
            |     .:::.::..::.|..::  :...:|...|..|.:|  .:....|..|......::..||
 Worm    62 DRLAVMKEEMANVYRMKSKNDQDLIDANRKLADSESRYSLV--SSQRDKLRIETDAIVKKMTVLE 124

Human   137 ARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKAR 201
            ..:|:|:|              :|:|......:|.|..........:|..|...||.|:.:.:.:
 Worm   125 NELAELKE--------------ENSVINTERVSLVATCNYLTEKKTQLDNERFQLLNRIRELQEK 175

Human   202 AAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEA 266
            :|...|.....:|...|.|:.:::   ||.|..::     |||    .|.:.|....||.|::
 Worm   176 SAEFMNAEIALQEERAQMRIREQI---AKATADLN-----LGD----ERASSAFGTSPETLDE-- 226

Human   267 CEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDV 331
                                                          :.:..|     ||:..:..
 Worm   227 ----------------------------------------------FMMTDV-----LPSEVKFK 240

Human   332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQ--TLEGAGGSITSVDFDPSGYQ 394
            |..|..||:.|.: .:....||.|:|..:.:|.|..::.:|::  ||.|..|.:..:|:|...:.
 Worm   241 LSTHDGEVHDVEW-MSDDTFATAGSDSKVQIWRVSPNKTDASKVSTLSGCLGPVNRLDYDSQRHV 304

Human   395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRT 459
            .||::.::..:||.:...:...|.|||.|||::|:. ...|..::||.|||:|.||:....|.::
 Worm   305 CLASSNDKTCRLWNIDSQRLLSTFSGHTDKVSSARL-FQSHNVISGSADRTIKNWDISSIRCLKS 368

Human   460 INVLSYCNDVV--CG--DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSC 520
            ..|.|...|:|  ||  ....||.|.|:|:||||:|....|..:.:..:|:||.:|.|.|.:|:.
 Worm   369 YLVGSTVFDIVAKCGVSQSSFISSHFDKKVRFWDARSSDATYSVELGQKVSSLDISMDGLQVLAS 433

Human   521 SRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLES- 584
            |||:||.:||:|...|..::.|:.:|...|.|:|:||....|.||||.:.:::||:..|.|||.
 Worm   434 SRDDTLSLIDVRNYGIIHLYSAEQYKTSCDSTRAIFSSTGEYVLAGSSNSSVFIWNTKTTKLEKV 498

Human   585 -RLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
             :......|.:.::||..||..:::.|:.:...||:
 Worm   499 VKTARSDSAQIMSLAWNPSGRGLLACDRQKTCTLWR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L2	NP_203746.1	WD40 repeat	505..543	CDD:293791	16/37 (43%)
		WD 6. /evidence=ECO:0000255	546..585		17/40 (43%)
		WD40 repeat	551..587	CDD:293791	15/37 (41%)
		WD 7. /evidence=ECO:0000255	589..619		7/29 (24%)
		ATG16	32..203	CDD:462536	28/177 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..78		3/20 (15%)
		SMC_N	<121..>295	CDD:481474	32/173 (18%)
		WD40	331..619	CDD:238121	98/295 (33%)
		WD 1. /evidence=ECO:0000255	334..373		10/38 (26%)
		WD40 repeat	341..378	CDD:293791	10/38 (26%)
		WD 2. /evidence=ECO:0000255	378..417		8/38 (21%)
		WD40 repeat	384..420	CDD:293791	7/35 (20%)
		WD 3. /evidence=ECO:0000255	420..454		15/33 (45%)
		WD40 repeat	425..461	CDD:293791	12/35 (34%)
		WD 4. /evidence=ECO:0000255	455..498		18/46 (39%)
		WD40 repeat	467..499	CDD:293791	15/35 (43%)
		WD 5. /evidence=ECO:0000255	500..539		16/38 (42%)
atg-16.2	NP_495299.2	DR0291	60..>206	CDD:441187	30/164 (18%)
		WD40	241..524	CDD:238121	96/284 (34%)
		WD40 repeat	294..330	CDD:293791	7/35 (20%)
		WD40 repeat	335..371	CDD:293791	12/36 (33%)
		WD40 repeat	379..411	CDD:293791	14/31 (45%)
		WD40 repeat	418..456	CDD:293791	16/37 (43%)
		WD40 repeat	464..502	CDD:293791	15/37 (41%)