Protein Alignment ATG16L2 and atg16l2

DIOPT Version :10

• Sequence 1: NP_203746.1
• Gene: ATG16L2 / 89849
• HGNCID: 25464
• Length: 619
• Species: Homo sapiens
• Sequence 2: XP_004919969.2
• Gene: atg16l2 / 100485143
• XenbaseID: XB-GENE-6047387
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 616
• Identity: 260/616 - (42%)
• Similarity: 369/616 - (59%)
• Gaps: 45/616 - (7%)

Human    12 ARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEES 76
            |.|||||:|||:.|||||.|.|.:::.:||.||||:.||.:.::.:|.||.|.......||....
 Frog    12 AGWKRHIIRQLKHRDRTQNARFHDVIHSYNKLLEKSTLLKQLTETIQTEPGSRFHDEAPGPPGVP 76

Human    77 ELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALEARVAQ 141
            |.|..            |:|.|.|....|::|::..|..|.:...|..::.:.:|:|.|    :.
 Frog    77 ETDGQ------------QKEMEELDTYNGKLAFEACEMRARIQAQEDVMRIQNTRMADL----SH 125

Human   142 LREARAQQAQQVEE---W-RAQNAVQRAAYEALRAHVGLREAALR-RLQEEARDLL---ERLVQR 198
            ..|::..|..|:.:   | .|.||..:..|:    ||..::..|. ..|.:...||   :.:::|
 Frog   126 TLESQINQKNQLLDDLAWIVATNADLKEDYD----HVHRQKQGLEAEYQSKVVALLAITDDIMKR 186

Human   199 KARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLE 263
            ||..|..:|..|:||   |:....:..|||.::.||        .|...|..:|..........|
 Frog   187 KAADAENQNELNDRR---KEELWRRHCKKALRKCVS--------SDAGLEHTQTAGGTETSGSAE 240

Human   264 KEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIP-VCVAARLPTR 327
            .||..|   ..||.|..||..|..:..::.:|.|..|:| .:....|:.:...| |||...:||:
 Frog   241 GEATVK---KTRSQSMISLGTSRFMGTIRNVLGFSFRKG-KVDLPREEPWHCSPNVCVLCCVPTK 301

Human   328 AQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSG 392
            |....:.|.|||:||:|.|||..:|||||||:|.:|||....|:..:||||:||.|||::|||||
 Frog   302 ALCNKEVHESEVHAVQFSPNSRTVATGGADRVIKIWNVNHGMLQVCRTLEGSGGGITSIEFDPSG 366

Human   393 YQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCS 457
            .|:||::::.||.|||: :.::.|:|:||..||||||||::.::|||.|.|||::||||.:|.|.
 Frog   367 LQILASSFDGAAHLWKL-DGKAYESLTGHTGKVTAAKFKMSLYRAVTCSLDRTIREWDLQKAACI 430

Human   458 RTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSR 522
            |.|:|.|||:||||.|:.:||||:|:||||||||...|.:.:.::.::|||.:..:|..||||||
 Frog   431 RRISVSSYCSDVVCSDYYMISGHHDKKIRFWDSRSESCFREVTLEEKITSLFMDQEQGQLLSCSR 495

Human   523 DNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQ 587
            |:.|.:.|||.||:||||||||||||.|||||:.|||.||.||||.||.::||:..||.||..|.
 Frog   496 DDALSLFDLRSSNVRQVFRADGFKCGCDWTKAILSPDGSYTLAGSADGTIFIWNTRTGLLERSLN 560

Human   588 GPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
            |.|.|:||||.|..||.::||||:|:..|:|
 Frog   561 GQHRASVNAVTWSMSGDYVVSVDRGKMAVVW 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L2	NP_203746.1	WD40 repeat	505..543	CDD:293791	22/37 (59%)
		WD 6. /evidence=ECO:0000255	546..585		25/38 (66%)
		WD40 repeat	551..587	CDD:293791	21/35 (60%)
		WD 7. /evidence=ECO:0000255	589..619		16/30 (53%)
		ATG16	32..203	CDD:462536	46/178 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..78		6/20 (30%)
		SMC_N	<121..>295	CDD:481474	45/181 (25%)
		WD40	331..619	CDD:238121	163/288 (57%)
		WD 1. /evidence=ECO:0000255	334..373		22/38 (58%)
		WD40 repeat	341..378	CDD:293791	20/36 (56%)
		WD 2. /evidence=ECO:0000255	378..417		19/38 (50%)
		WD40 repeat	384..420	CDD:293791	17/35 (49%)
		WD 3. /evidence=ECO:0000255	420..454		21/33 (64%)
		WD40 repeat	425..461	CDD:293791	21/35 (60%)
		WD 4. /evidence=ECO:0000255	455..498		26/42 (62%)
		WD40 repeat	467..499	CDD:293791	19/31 (61%)
		WD 5. /evidence=ECO:0000255	500..539		18/38 (47%)
atg16l2	XP_004919969.2	ATG16	33..195	CDD:462536	47/181 (26%)
		WD40	<309..592	CDD:441893	163/284 (57%)
		WD40 repeat	315..352	CDD:293791	20/36 (56%)
		WD40 repeat	358..393	CDD:293791	17/35 (49%)
		WD40 repeat	398..432	CDD:293791	20/33 (61%)
		WD40 repeat	440..473	CDD:293791	19/32 (59%)
		WD40 repeat	478..516	CDD:293791	22/37 (59%)
		WD40 repeat	524..560	CDD:293791	21/35 (60%)
		WD40 repeat	567..591	CDD:293791	13/23 (57%)