DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie1 and btl

DIOPT Version :9

Sequence 1:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	242/954 - (25%)
Similarity:	382/954 - (40%)	Gaps:	244/954 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat   347 KSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRGS-MELRKPDG-----------TMLLST 399
            :||...|.||.:..|:. |..:|:.....||..|.:..| |:   ||.           |.:|..
  Fly   128 ESDLFFQPLNESRSLKL-LQPLPKTVQRTAGGLFQLNCSPMD---PDAKGVNISWLHNDTQILGG 188

  Rat   400 KAIVEPDRTTAEFEVPRLTLG-----DSGFWECRVSTSGGQDSRR-----FKVNVKVPPVPLTAP 454
            :..::..|.:       ||:|     |:|.:.|.:...  ||.:|     .:|..:...||:..|
  Fly   189 RGRIKLKRWS-------LTVGQLQPEDAGSYHCELCVE--QDCQRSNPTQLEVISRKHTVPMLKP 244

  Rat   455 RLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMITW-------------------SAIVVD 500
            ......|..|         ||.......|.....:..|||                   |.:.||
  Fly   245 GYPRNTSIAL---------GDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVD 300

  Rat   501 PSENVTLMNLKP---RTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDR 562
            .:..:|.|: :|   |.| ||.::        :|.| ...:........:...:|:.::......
  Fly   301 VTRLITRMD-EPQVLRLG-NVLME--------DGGW-YICIAENQVGRTVAASYVDLYSPSDTTT 354

  Rat   563 LR------VSWSLPSVPLSGDGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRL 621
            :|      |:..:|:              .:.|::..:::.:|.|..:  .|:.|....:...||
  Fly   355 VRTTTTTTVASPIPT--------------ASTGEDNDDDVENPAAEAS--GGVGPPVFRKELKRL 403

  Rat   622 YH------CTLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEI 680
            .|      ..|..|....|::.......|..|.|......:..:|.:    ||.......|..::
  Fly   404 QHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFV----EATSEDSGLYNCKV 464

  Rat   681 QVAGG----SGDPQWMD-------VDKPEETSTTVRGL-------------NASTRYLFRVRASV 721
            ..|.|    ....|..|       :..|:..:..|.|.             ..|.:.:....||:
  Fly   465 CNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL 529

  Rat   722 QGLGDWSNTVEETTLGNGLQSASPVQESR------------VAEDGL---DQQLVLAVVGSV--- 768
            .||    .:||...|...:.:.|.|...|            :|..||   :..:.|.||..:
  Fly   530 DGL----KSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPL 590

  Rat   769 -------------SATCLTILAALL----------------ALVCIRRSCLHR--RHTFTYQSGS 802
                         :...:||:|..|                .|:.:|...:|:  :....|:.|
  Fly   591 EIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPG- 654

  Rat   803 GEE-----------TILQFSSGTLTLTRRPKPQPEP------LSYPV-LEWE----DITFEDLIG 845
            |||           .:::......|::.......:|      ..:|: ..||    .::...::|
  Fly   655 GEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILG 719

  Rat   846 EGNFGQVIRAMIKKDGLKMN-------AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLL 903
            ||.||:|:  |.:.:||..:       .|:||:||..::.|......|:||:..:|.|.||||||
  Fly   720 EGAFGRVV--MAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLL 782

  Rat   904 GACENRGYLYIAIEYAPYGNLLDFLRKSR------------VLETDPAFAREHGTASTLSSRQLL 956
            |.|...|.|::.:||||:|||.|||:::|            .|:..|..:.:|     |..::|.
  Fly   783 GCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQH-----LGEKELT 842

  Rat   957 RFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRW 1018
            :||...|.||:||:.::.||||||||||||.:....|||||||:|   ..|.|.|.|.||||::|
  Fly   843 KFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKW 907

  Rat  1019 MAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA-ELYEKLPQGYRMEQPRNCDDEVY 1082
            ||.|||....|.::|||||:|||||||::.|..||..:..| |||..|..|.|||:|..|...:|
  Fly   908 MAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIY 972

  Rat  1083 ELMRQCWRDRPYERPPFAQIALQLGRMLE-----ARKAYVNMSL 1121
            .:|||||......||.||::......:|:     ...||:::|:
  Fly   973 VVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSM 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie1	NP_445997.1	ig	130..211	CDD:278476
		EGF_Lam	228..266	CDD:238012
		EGF_CA	315..346	CDD:238011
		ig	357..442	CDD:278476	22/106 (21%)
		IG_like	370..444	CDD:214653	20/95 (21%)
		fn3	450..530	CDD:278470	20/101 (20%)
		fn3	549..631	CDD:278470	14/93 (15%)
		FN3	643..735	CDD:238020	21/115 (18%)
		PTKc_Tie1	835..1131	CDD:270671	130/319 (41%)
		TyrKc	838..1106	CDD:197581	124/290 (43%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	20/94 (21%)
		IGc2	157..215	CDD:197706	14/67 (21%)
		IG	247..336	CDD:214652	20/108 (19%)
		Ig	258..340	CDD:143165	16/92 (17%)
		I-set	394..479	CDD:254352	15/88 (17%)
		IGc2	408..469	CDD:197706	11/64 (17%)
		IG_like	492..583	CDD:214653	18/94 (19%)
		Ig	507..583	CDD:299845	15/79 (19%)
		PKc_like	700..1000	CDD:304357	127/306 (42%)
		TyrKc	712..996	CDD:197581	124/290 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810