DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC10 and CG45263

DIOPT Version :9

Sequence 1:	NP_149121.2	Gene:	SIGLEC10 / 89790	HGNCID:	15620	Length:	697	Species:	Homo sapiens
Sequence 2:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	174/770 - (22%)
Similarity:	275/770 - (35%)	Gaps:	184/770 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLPLLLSSLLGGSQAMDGRF-----WIRVQES--------VMVPEGLCISVPCSFSYPRQDWTG 52
            :|:.:.::|.|.||:... ||     :..|..:        |:...|.|            .|..
  Fly    35 LLIGIAVASCLPGSEGFQ-RFSEQPKYTEVNPAEDTLLTCKVIDKRGTC------------SWQK 86

Human    53 STPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQ-DESQY 116
            .....|.:.|.. |.....|.:.|.....:::.. ...||.||     |||.||.|.:. |:..:
  Fly    87 DNKPVGIYTKKY-EWASRMPTSDNGNVLHLDLHP-PPVQLGGD-----CSLWIRSATLDFDDGLW 144

Human   117 FFRVERGSYVRYNFM-NDGFFLKVTALTQKP-----DVYIPE----TLEPGQPVTVICVFNWAFE 171
            ..:|....:...:.: :....|.|....|:|     .|::|.    |.:.|...||.|:.::.
  Fly   145 ECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCISHYG-- 207

Human   172 ECPPPSFSWTGAALSSQGTKP--------------TTSHFSVLSFTPRPQDHNTDLTC---HVDF 219
             .||.:..|   .|..|...|              |.|..||:..:...:.|...|.|   |..:
  Fly   208 -NPPATLKW---FLGDQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHGDILRCAAYHESY 268

Human   220 SRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPA 284
            :.|.|..:  .||.|.|||     ||....:|.::         ||..| ..|.|.|.||:.|||
  Fly   269 TAKSVVVE--ARLDVKYAP-----SIRLIGSPEID---------LEEDK-DALVLRCVADANPPA 316

Human   285 TLSWVLQNR--VLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLG-SQQRALDLSVQYPPEN 346
            ::.|....|  :.|.......||:|..       |:|.|||:|:|.:| |:|.::.|.|:|||
  Fly   317 SIVWRRAGRSEIASLQETLQLRPVGRR-------DAGLYTCQAQNSVGTSEQLSVQLDVKYPP-- 372

Human   347 LRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGV-- 409
             :::.:..:|.        |:.|:.  ......|:...:|.....|.||  :...|:..:.|.
  Fly   373 -KIISAGPDRL--------TTAPLF--SPAAFECLADGNPLPSFKWVQR--MAHGSKYVERGSES 424

Human   410 -LELPRVQVEHEGEFTCHARHPL-GSQHVSL----SLSVHYSPKL--LGPSCSW----EAEGLHC 462
             |.:..|..|::||:.|.|...: |.:.|::    ||.|..:|::  |.||...    ..|....
  Fly   425 RLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAASL 489

Human   463 SCSSQASPAPS-LRWWLGEELLEGNSSQDSF---EVTPSSAGPWANSSLS-LHGGLSSGLRLRCE 522
            :....|.|.|. :.|..|...||..|..|.|   ::.|.:......|:|. ||............
  Fly   490 TMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYYLV 554

Human   523 AWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGI--GITA--LLFLCLALIIMKI---------- 573
            ..|..|....:|..:.:  |..:..:.....:|:  |..|  ||.:||.:..:|.
  Fly   555 VENERGTDRHAIHLIVE--GTFAEPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKGSTG 617

Human   574 ------------LPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQK------------ 614
                        |..|...|..|:.         |.|...|......|::.|:
  Fly   618 YKSSDKDSEKADLKSRSDSTSGPQG---------DSIYTTPAGFHHHQQQQQQQQQQQHAAAAAA 673

Human   615 ----ATPNSPRTPLPPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQESQEEL 665
                |....|:... ||..|||:.|.:.....|.  |..:.......:.||.|:|
  Fly   674 AALHAASQHPQQQY-PGHGSPEAMKVRMAAMILQ--PPTRVXQAIDTTSESNEQL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC10	NP_149121.2	Ig	23..140	CDD:299845	23/126 (18%)
		IG_like	26..126	CDD:214653	21/108 (19%)
		IG_like	262..340	CDD:214653	28/80 (35%)
		IGc2	269..330	CDD:197706	21/62 (34%)
		IG_like	367..442	CDD:214653	19/82 (23%)
		Ig	378..439	CDD:143165	16/68 (24%)
CG45263	NP_731246.2	I-set	53..149	CDD:254352	23/114 (20%)
		Ig	198..281	CDD:299845	21/90 (23%)
		IG_like	302..368	CDD:214653	25/72 (35%)
		IGc2	302..357	CDD:197706	21/61 (34%)
		Ig	372..446	CDD:299845	18/88 (20%)
		Ig	475..568	CDD:299845	20/92 (22%)
		IG_like	478..570	CDD:214653	19/91 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11775
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910