DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIGLEC10 and LOC101884840

DIOPT Version :10

Sequence 1:NP_149121.2 Gene:SIGLEC10 / 89790 HGNCID:15620 Length:697 Species:Homo sapiens
Sequence 2:XP_068069729.1 Gene:LOC101884840 / 101884840 -ID:- Length:716 Species:Danio rerio


Alignment Length:783 Identity:164/783 - (20%)
Similarity:272/783 - (34%) Gaps:224/783 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     4 PLLLSSLLGGSQAMDGRFW-IRVQESVMVPEGLCISVPCSFS---YPRQDWTGSTPAYGYWFKAV 64
            ||||..||.|....|...| :.:.:::...:|.|:.:|||||   ||.:|     |....|::.|
Zfish     3 PLLLKLLLQGVLLFDALAWNVNMPQAIHGLQGSCLVIPCSFSYTLYPPKD-----PRRVVWYQWV 62

Human    65 TETTKGAP-VATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFR---VERGSY 125
               ::|.| |..:...|:|....||:..|..: :..:|||:|::.:.....:..:.   .|...:
Zfish    63 ---SRGYPLVYDSWYPRDVIDKFRGKTDLYRN-SGWDCSLLIKNLEQSHHREKIYAWIDPENVGW 123

Human   126 VRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGT 190
            ..|.|.:....:.|......|.:.|....:.|..:||:|.   :|..||     |:...::..|.
Zfish   124 RTYAFYDITSTILVENQPPTPTILIYGGEKMGDKITVVCS---SFHTCP-----WSKPNITLNGA 180

Human   191 KPTTS-----------HFSV-LSFTPRPQDHNTDLTCHVDF-SRKGVSA-----QRTVRLRVAYA 237
            |.:.|           |..: |:.|...:..||...|.|.: ..|.:||     .:.|..|:...
Zfish   181 KGSESDQIKDECNEYGHCKINLTRTVVVKAENTAFNCSVTYHGGKSISAAIDKSAQCVHHRIVIE 245

Human   238 PR--DLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHP 300
            |.  |:...::::.|..:         |...||            :.| ::||..:|..:|    
Zfish   246 PEMADVTEGVAQNFTCTI---------YHSCQK------------ENP-SISWNYENMQVS---- 284

Human   301 WGPRPLGLELPGVKAGDSGRYTCRAENR--------LGS---QQRALDLSVQYPPEN------LR 348
                             .||.|....:|        ||:   |.|.|..:..:...|      ||
Zfish   285 -----------------EGRKTLSGSDRVAFSNITFLGTIEDQGRKLTCTASFSGGNIAASAVLR 332

Human   349 VMVSQ------ANRTVLENLGNG----TSLP----VLEGQSLCLVCVTHS-SPPARLSW-TQRGQ 397
            |...|      .|.|..:.:.:.    |:||    |:.    |...|.|. ....|:.| ...|.
Zfish   333 VQKYQKPAIPVQNETYFQYMADVIPEITALPRSCVVIP----CSFSVEHKYLTGLRVRWVNNNGG 393

Human   398 VLSPSQPSD--------------PG----VLELPRVQVEHEGEFTCHA-----RHPLGSQHVSLS 439
            .:..:.|.|              |.    .||:..|:....|.|...|     ::...:..|.:.
Zfish   394 YMYHTDPVDVLDNFKGRTRLLGNPDERNCTLEMDDVRTHDNGPFCFQAEKKEEKYSFNNSCVFII 458

Human   440 L----------SVHYSPKLLGPSCSWEAEGLHCS----CSSQASPAPSLRWWLGEELLEGNSSQD 490
            :          ||   |:.:.|.   .|..:.||    |||.   .|.:.|.:       .:.::
Zfish   459 MRASPDQPVMSSV---PEDIEPG---TAVTVKCSVKHTCSSH---PPKITWSV-------PTVRE 507

Human   491 SFEVTPSSAGPWANSSLS--LHGGLSSGLRLRCEAWNVHG--AQSGSILQLPDKKGLISTAFSNG 551
            :....|...|.|...|..  :..|......:.|.| |..|  .||.|...|..|:   ..|..:|
Zfish   508 TISHNPMGGGVWETVSKMKFIPTGYEEEDEIICSA-NFWGGKTQSNSSAPLSVKR---IQAVESG 568

Human   552 AFLGIGITALLFLCLALIIMKILPKRR--------TQTETPRPRFSRHSTILDY----------- 597
            .:  |..::|:|:.:.::....:.||.        |::|..|..::|.|:....           
Zfish   569 PY--IIASSLVFVLICILAGVFMYKRHQRQPCEDITRSEQRRSVWNRFSSRFSMPEGRAAWFNSG 631

Human   598 ----INVVPTAGPLAQKR----NQKATPNSPRTPLPPGAPSPESKKN------QKKQYQLPSFPE 648
                |...|...|..::|    ::.:...|||......|   |.|.|      :.|.:..|..|.
Zfish   632 NRSDIRDAPGRPPKPEQRRSIWSRFSRHQSPRNNANMRA---EYKANNTCNVPENKDFNKPHMPS 693

Human   649 PKS 651
            |.|
Zfish   694 PNS 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGLEC10NP_149121.2 IgV_CD33 21..140 CDD:409377 29/126 (23%)
FR1 21..45 CDD:409377 8/27 (30%)
Ig strand A 21..25 CDD:409377 1/4 (25%)
Ig strand A' 28..32 CDD:409377 0/3 (0%)
Ig strand B 34..45 CDD:409377 7/13 (54%)
CDR1 46..55 CDD:409377 2/8 (25%)
FR2 56..63 CDD:409377 1/6 (17%)
Ig strand C 56..63 CDD:409377 1/6 (17%)
CDR2 64..87 CDD:409377 6/23 (26%)
Ig strand C' 74..77 CDD:409377 0/2 (0%)
FR3 88..121 CDD:409377 6/35 (17%)
Ig strand D 89..93 CDD:409377 0/3 (0%)
Ig strand E 99..107 CDD:409377 4/7 (57%)
Ig strand F 114..122 CDD:409377 0/10 (0%)
CDR3 122..126 CDD:409377 0/3 (0%)
FR4 127..140 CDD:409377 2/12 (17%)
Ig strand G 127..140 CDD:409377 2/12 (17%)
Ig 146..233 CDD:472250 24/104 (23%)
Ig strand B 160..164 CDD:409353 2/3 (67%)
Ig strand C 177..181 CDD:409353 0/3 (0%)
Ig strand E 198..202 CDD:409353 1/4 (25%)
Ig strand F 212..217 CDD:409353 1/4 (25%)
Ig strand G 227..230 CDD:409353 0/2 (0%)
Ig 261..342 CDD:472250 17/91 (19%)
Ig strand B 272..276 CDD:409353 0/3 (0%)
Ig strand C 285..289 CDD:409353 1/3 (33%)
Ig strand E 309..313 CDD:409353 0/3 (0%)
Ig strand F 320..325 CDD:409353 2/4 (50%)
Ig strand G 335..338 CDD:409353 1/2 (50%)
Ig 365..444 CDD:472250 22/121 (18%)
Ig strand B 376..380 CDD:409353 1/3 (33%)
Ig strand C 389..393 CDD:409353 2/4 (50%)
Ig strand E 411..415 CDD:409353 1/3 (33%)
Ig strand F 422..427 CDD:409353 1/4 (25%)
Ig strand G 437..440 CDD:409353 0/2 (0%)
LOC101884840XP_068069729.1 Ig strand F 537..542 CDD:409579 1/4 (25%)
Ig strand G 552..555 CDD:409579 1/2 (50%)
Ig 21..>107 CDD:472250 26/94 (28%)
Ig strand B 37..41 CDD:409353 0/3 (0%)
Ig strand C 55..59 CDD:409353 0/3 (0%)
Ig strand E 96..100 CDD:409353 3/3 (100%)
Ig 250..327 CDD:472250 20/119 (17%)
Ig strand B 257..261 CDD:409579 0/3 (0%)
Ig strand C 273..277 CDD:409579 1/3 (33%)
Ig strand E 299..303 CDD:409579 0/3 (0%)
Ig strand F 313..318 CDD:409579 1/4 (25%)
Ig 359..450 CDD:472250 19/94 (20%)
Ig strand B 367..371 CDD:409353 1/7 (14%)
Ig strand C 384..388 CDD:409353 1/3 (33%)
Ig strand E 422..426 CDD:409353 1/3 (33%)
Ig strand F 436..441 CDD:409353 1/4 (25%)
Ig 470..557 CDD:472250 24/103 (23%)
Ig strand B 481..485 CDD:409579 0/3 (0%)
Ig strand C 497..500 CDD:409579 0/2 (0%)
Ig strand E 523..527 CDD:409579 1/3 (33%)

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