DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC10 and LOC101884775

DIOPT Version :9

Sequence 1:	NP_149121.2	Gene:	SIGLEC10 / 89790	HGNCID:	15620	Length:	697	Species:	Homo sapiens
Sequence 2:	XP_009298710.1	Gene:	LOC101884775 / 101884775	-ID:	-	Length:	509	Species:	Danio rerio

Alignment Length:	705	Identity:	139/705 - (19%)
Similarity:	217/705 - (30%)	Gaps:	277/705 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     5 LLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSF----SYPRQDWTGSTPAYGYWFKAVT 65
            ::...||.|....|  |.|.:.|.:....|.|:.:.|.|    :|.: |.|  ..|.|.|:|. |
Zfish     8 IIFCFLLQGVCCRD--FNISLPEKIQALSGSCVVIKCRFEINETYDK-DLT--ERAAGVWYKD-T 66

Human    66 ETTKGAPVATNHQSREVEMSTRGRF---QLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVR 127
            .....:||..:      ..||:..|   .:||.....:|:.|..|.......|||||:|.
Zfish    67 HDKSSSPVFNS------SASTQNSFIKGNITGQLNYKDCTTVFYDVTSNHSGQYFFRIEG----- 120

Human   128 YNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKP 192
                                       |.|        ..|.|                   ||.
Zfish   121 ---------------------------EGG--------LKWTF-------------------TKS 131

Human   193 TTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQP 257
            .|| ..|:.....||                                 :|:.:   |...|:.|.
Zfish   132 NTS-VVVIESPVNPQ---------------------------------VVLYV---NEQELQDQQ 159

Human   258 QGNVPYLEAQKGQFLRLLCAAD---SQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSG 319
                   |..:|:.:.|.|:||   |.|||||:|        ||
Zfish   160 -------EVLEGRSVSLRCSADDLCSSPPATLTW--------SS--------------------- 188

Human   320 RYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHS 384
              |.|..:...|:.:.|             ::|..|.|.
Zfish   189 --TARIPHSESSKLQEL-------------IISDLNFTA-------------------------- 212

Human   385 SPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPL----GSQHVSLSLSVHYS 445
                                          .|..|...|||...:.|    .:.|.|::|.|.|:
Zfish   213 ------------------------------AQRHHRVTFTCSISYQLQDNNKTAHSSITLHVQYA 247

Human   446 PKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSLH 510
            |::|..||:.....: |.|....:|:|.:.|.|...|:..:|:....|...|:..  ..|.:||.
Zfish   248 PQILNSSCNIGNVNV-CFCEVDGNPSPVVEWHLSGRLVSNSSNMFISEERLSNTS--LRSFISLD 309

Human   511 GGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITALLFLCLALIIMKILP 575
            ..|:....|.|.:.|.||.:|   |||     |.|:...:.:|:.||:..:|.:.|..:|:.:..
Zfish   310 QSLTQTSTLLCVSKNTHGNES---LQL-----LPSSTRLSFSFMLIGVAVVLLVTLISVIIYLRK 366

Human   576 KRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPLPPGAPSPESKKNQKKQ 640
            :|....:|.:...::.|            |..|.|.|:..:..:..:.:.....:|:..:.:...
Zfish   367 ERGKLQQTKQEESAKGS------------GQNADKENEGDSLYATVSSVEDATANPDIHRQKSII 419

Human   641 YQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEARMPKGTQADYAEVK 695
            |....|...|:.:   |..||...||                      ||||.|:
Zfish   420 YSSIDFKNYKAES---EEVESVSCLH----------------------ADYAVVQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC10	NP_149121.2	Ig	23..140	CDD:299845	30/123 (24%)
		IG_like	26..126	CDD:214653	29/106 (27%)
		IG_like	262..340	CDD:214653	19/80 (24%)
		IGc2	269..330	CDD:197706	16/63 (25%)
		IG_like	367..442	CDD:214653	9/78 (12%)
		Ig	378..439	CDD:143165	8/64 (13%)
LOC101884775	XP_009298710.1	Ig	22..137	CDD:299845	39/184 (21%)
		Ig	154..230	CDD:299845	29/182 (16%)
		IG_like	158..244	CDD:214653	32/192 (17%)
		DUF499	276..>493	CDD:303008	48/221 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I34127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010