DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC10 and si:ch73-380l3.2

DIOPT Version :9

Sequence 1:	NP_149121.2	Gene:	SIGLEC10 / 89790	HGNCID:	15620	Length:	697	Species:	Homo sapiens
Sequence 2:	NP_001348166.1	Gene:	si:ch73-380l3.2 / 100003913	ZFINID:	ZDB-GENE-080303-1	Length:	266	Species:	Danio rerio

Alignment Length:	227	Identity:	63/227 - (27%)
Similarity:	96/227 - (42%)	Gaps:	30/227 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    22 W-IRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAY---GYWFKAVTETTKGAPVATNHQSREV 82
            | :.|:..:......|:.:||:|:||...  ...|:|   |.|.|    ..|...:........|
Zfish    24 WKVDVEHKMKALVSSCVVLPCNFTYPVHQ--QQQPSYRIRGIWHK----MNKWDDIIFYGDKTLV 82

Human    83 EMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRV--ERGSYVRYNFMNDGFFLKVTALTQK 145
            |.:.:||.:|.|.....||||.|.:.:..|...|.|||  |.....:|:|:::...:.......|
Zfish    83 EDNFKGRTRLIGSLGSFNCSLEIDEVKNTDNGPYCFRVELETAPKDKYSFVDNCVSITTIEEAPK 147

Human   146 PDVYIPETLEPGQPVTVICVFNWAFEECP--PPSFSW--TGAALSSQGTKPTTSH-----FSVLS 201
            |.:....::..|:|....|...   ..||  .|||||  .|..:||..   ...|     .|:|:
Zfish   148 PMLEAETSVLEGEPAIFKCSVR---HTCPTYQPSFSWNRAGKIISSYN---DLGHGNWEAESLLT 206

Human   202 FTPRPQDHNTDLTCHVDF--SRKG-VSAQRTV 230
            |||..:|:.|.:.|.|.:  :.|| :.|.|.|
Zfish   207 FTPTKEDNYTSIECTVKYHGNVKGEMKASRPV 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC10	NP_149121.2	Ig	23..140	CDD:299845	32/121 (26%)
		IG_like	26..126	CDD:214653	29/104 (28%)
		IG_like	262..340	CDD:214653
		IGc2	269..330	CDD:197706
		IG_like	367..442	CDD:214653
		Ig	378..439	CDD:143165
si:ch73-380l3.2	NP_001348166.1	Ig	24..141	CDD:325142	33/122 (27%)
si:ch73-380l3.2	NP_001348166.1	Ig	148..226	CDD:325142	24/83 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I12412
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.060