Protein Alignment HPS4 and Hps4

DIOPT Version :10

• Sequence 1: XP_011528788.1
• Gene: HPS4 / 89781
• HGNCID: 15844
• Length: 752
• Species: Homo sapiens
• Sequence 2: NP_001100618.2
• Gene: Hps4 / 304555
• RGDID: 1308070
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 759
• Identity: 427/759 - (56%)
• Similarity: 488/759 - (64%)
• Gaps: 105/759 - (13%)

Human     1 MATSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVS 65
            ||.:|..|.|||:|||||||||||||:.||||||||||||||||||||||||||||:||||||:.
  Rat     1 MANTTPPETKSAAWWNYFFLYDGSKVQGEGDPTRAGICYFYPSQTLLDQQELLCGQLAGVVRCLW 65

Human    66 DISDSPPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENC 130
            |:|.:||.|:|||.||||::|||||||.|||.|||.|.||::|||||:|||:||.|||||||::.
  Rat    66 DLSGTPPMLIRLRNLKFALRVDGDYLWALGCGVELSDASCRQFLDQLIGFFHFYMGPVSLAYKSH 130

Human   131 SQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKSHGTWSDIKPPVSPWGLCFRRKVEDRVE 195
            .||||..:|||||.|:|::||:.|:|||:|||||:||                          ||
  Rat   131 PQEELRLQWDTFITQVLRSTSESHRIFNALWNLDRTK--------------------------VE 169

Human   196 PLLLLKAARILQTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQE 260
            ||||||||.||||||||||:|||||||:||||::|||||||||||||.|...:||.|....|.||
  Rat   170 PLLLLKAALILQTCQRSPHVLAGCILYEGLIVNSQLPPSLTAKVLLHHTVAADQRPPGAGAATQE 234

Human   261 HGKWMLWSFKNRVTHQNPNGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSLASPAGLQDGSA 325
                              .|.||||.|||.|||:::||..||||||||...|       |::.|.
  Rat   235 ------------------TGPALPPAVQITPVFLSEEEVASLHEFPVEHDPR-------LEESSF 274

Human   326 QHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHD--LESIR--PAGLH 386
            |..|...||....|:        |||:.....|          ..|..||.  ||..|  |.||.
  Rat   275 QCPPWDQSTPTGAED--------AWTSATVLEP----------TPCGGGHSPRLEQERAGPTGLC 321

Human   387 NSARGEVLGLSSSLGKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLS 451
            ..|......||..|.:||. |.:|||||.:|:.|||:        ||..||..      |.....
  Rat   322 TEACDRSSDLSGRLQRELC-LSQELDLSAMHLSEAQD--------AFPPVPAS------CDLQAL 371

Human   452 ASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHP---GHSSQAPIPRADPLPRRTRRPL 513
            ..|...||.||||||.|...||..|...:.|:.|.|.|.|   ||:.   :|..:||| .:|..:
  Rat   372 CVSRDTPTLPEDTAICSCLDPSPLERPPEGGSLEALADLPLTHGHTH---VPGTEPLP-SSRTMV 432

Human   514 LLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAES 578
            |||:...|......|.|....|.          .|.|..||.||:.||..||||......:|:..
  Rat   433 LLPQHPEGVEPGVEPCGSGAQDR----------LPALARSSHSADSQGPSPSADRTGFNPSPSGP 487

Human   579 CMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLNGLEVHLKETLPRDEAASTS 643
            ..||:.||||||.|.||||||||:|.|..|:|||||||||||||||||||||||||||||.:.|.
  Rat   488 HAGLMPMNLYTHSVNGLVLSLLAKETLGSDTAAIEEVYHSSLASLNGLEVHLKETLPRDETSPTG 552

Human   644 STYNFTHYDRIQSLLMANLPQVATPQDRRFLQAVSLMHSEFAQLPALYEMTVRNASTAVYACCNP 708
            |||||.|||||||:|.||||.||.||:|||||||:||||:|||||.|||||:||||||||||.||
  Rat   553 STYNFLHYDRIQSVLSANLPLVAAPQNRRFLQAVNLMHSDFAQLPMLYEMTIRNASTAVYACSNP 617

Human   709 IQETYFQQLAPAARSSGFPNPQDGAFSLSGKAKQKLLKHGVNLL 752
            .||||||||||.|||||||||||.||||||||||||||||||||
  Rat   618 AQETYFQQLAPTARSSGFPNPQDCAFSLSGKAKQKLLKHGVNLL 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	XP_011528788.1	Intu_longin_1	15..121	CDD:436911	84/105 (80%)
		dnaA	<458..>575	CDD:455861	43/119 (36%)
		Intu_longin_3	642..743	CDD:436913	85/100 (85%)
Hps4	NP_001100618.2	Intu_longin_1	15..121	CDD:436911	84/105 (80%)
		PHA03307	225..>490	CDD:223039	112/336 (33%)
		Intu_longin_3	551..652	CDD:436913	85/100 (85%)