Protein Alignment USP13 and Usp32

DIOPT Version :10

• Sequence 1: NP_003931.2
• Gene: USP13 / 8975
• HGNCID: 12611
• Length: 863
• Species: Homo sapiens
• Sequence 2: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Alignment Length: 971
• Identity: 188/971 - (19%)
• Similarity: 315/971 - (32%)
• Gaps: 324/971 - (33%)

Human    59 EGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRR-------NSKI 116
            |..:|..:...|..|...::..||......|.|||..:      ::..:||...       ||:|
  Fly   923 ENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKL------STMCSLPPNLMLVCELWNSQI 981

Human   117 FLDLDTDDDLNSDD----YEYEDEAKLVIFPD-------------HYEIALPNIEELPALVTIAC 164
            ...|:.|:.|.:..    |.|:       .|:             |.|..|.:|:...||:|.|.
  Fly   982 RQVLNDDEKLRTQSAKELYVYQ-------LPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQ 1039

Human   165 DAVLS----SKSPYRKQDP-------------------------DTWENELP-VSKYANNLTQLD 199
            |::.|    ..|.:|....                         ::..|..| ||.|:.|.:. |
  Fly  1040 DSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSG-D 1103

Human   200 NGVR--IPPSGWKCARC-DLRENLWLNLTDGSVLCGK--WFFDSSGGN----GHALEHYRDMGYP 255
            |.|.  :|....|.:|| ..||.:     ..|:.|.|  ....||..|    |.|.:..|.....
  Fly  1104 NQVHELLPDEAGKVSRCFGKRECM-----PHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAK 1163

Human   256 LAVKLGTITPDGADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHGTENGLQDNDIKLRVSEWEVI 320
            |   |.|.:...:..|:....|..::..|.:.:....::.:   .:.||....|...|.|
  Fly  1164 L---LHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPV---SSRNGSGGEDCSYRTS----- 1217

Human   321 QESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNT 385
                    |....|.:....||.|..:.            ::|..||..   |:   |......|
  Fly  1218 --------PNDSSGLSTGHTLGASLDVD------------EQAEEGNAE---DH---DQPDQITT 1256

Human   386 QMTKLGHGLLSGQYSKPPVKS-----ELIEQVMKEE------HKPQQNGISPRMFKAFVSKSHPE 439
            ...:...|:.|.:.|:||.|:     .:..::.:.:      ||.:     |.:|.  |....|.
  Fly  1257 SQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTR-----PSLFG--VPLLIPN 1314

Human   440 FSSNRQQDAQEFFLHLVNLVERNRIGSENPSD--------------------VFRFLVEERIQC- 483
            ......:|     |:....::.:|:.|..|:.                    ..|.:..:.:.|
  Fly  1315 SEGGTHKD-----LYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCA 1374

Human   484 -------CQTRKVRYTERVDYLMQ--LPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKI 539
                   |:..::|...  ||::|  ||....||:|..                  .|:: .||.
  Fly  1375 ICPWSSFCRGCEIRCNN--DYVLQGALPPINAAASNTS------------------TPKM-NAKF 1418

Human   540 PFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSI- 603
            |....|:|...||         ..|..:...|:::          .:.||..:||.|....:..
  Fly  1419 PSLPNLEAKRTPE---------YTASLSYTPTTKY----------FEDFTIAIDWDPTALHLRYQ 1464

Human   604 ------------------DMPDLLDINH-LRA----------------RGLQPGEEELPDIS-PP 632
                              :..:.:|:|| |||                :|.:|..::|.... ||
  Fly  1465 STLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQWYHCSHCKGKKPATKKLQIWKLPP 1529

Human   633 IVIPDDSKDRLMN------QLI--------DP----SDIDESSVMQLAEMGFPLEACRKAVYFTG 679
            |:|....:...:|      |.:        ||    :.:.:.::::..|:   ||       ...
  Fly  1530 ILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKEL---LE-------LKN 1584

Human   680 NMGAEVAFNWIIVHMEE---PDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGF 741
            :....:|.|.::..::|   |.......:|...|:..|.||          ||.  ...|.....
  Fly  1585 DAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATAS----------PPP--TGNILRQSK 1637

Human   742 QRNQAIQALRATNNNLERA--LDWIFSHPEFEEDSDFVIEMENNANANIISEAKPEGPRVKDGSG 804
            .:| |::..|..:.:|.:.  :|     .|||:.....::                 |.|.....
  Fly  1638 TKN-AVRRQRLISTSLTKTPIVD-----GEFEDYHQHRLK-----------------PDVDQFDP 1679

Human   805 TYELFAFISHMGTSTMSGHYICHIKK-EGRWVIYNDHKVC--ASERPPKD--LGYMYFYRR 860
            .|.|:|.:||.|... .||||.:... .|.|..|||.. |  .|::|..|  ..|:.||.|
  Fly  1680 RYRLYAVVSHSGMLN-GGHYISYASNATGSWYCYNDSS-CREISQKPVIDPSAAYLLFYER 1738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP13	NP_003931.2	zf-UBP_var	35..98	CDD:407678	10/38 (26%)
		zf-UBP	211..284	CDD:460464	18/79 (23%)
		Peptidase_C19B	337..859	CDD:239123	116/627 (19%)
		UBA1_UBP13	652..700	CDD:270567	7/50 (14%)
		UBA2_UBP5	728..769	CDD:270569	8/42 (19%)
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	19/84 (23%)
		Peptidase_C19	<1480..1737	CDD:470612	63/303 (21%)