DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P4HA2 and CG34345

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	239/546 - (43%)	Gaps:	76/546 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     4 WVSALLMAWFGVLSCVQAE--------FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS 60
            |:   |:..|.|....:||        :..||..:::|...|...::.|..|:...:.|:..::.
  Fly    13 WI---LLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRI 74

Human    61 WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFI------ANLSVQ 119
            :.|.:.........|...|:::|:|::.|::|.:.|||.| ...|:|.  |.|      .|..:.
  Fly    75 FINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKL-IAYLKDQ--GNIKVDIEEMNKLIN 136

Human   120 RQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYH 184
            |.....|.:|  |...:.|::..|.|....:::|.:.|.:..:.:|..||..:....|...::..
  Fly   137 RTPHANDMEE--ALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRR 199

Human   185 TVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRY 249
            ...|....|...      |..|:.:. :..||. :..:|.:...::|
  Fly   200 AAEWYRIALSVF------TKPKNNIA-FKFYAP-KRKELEKMFVISR------------------ 238

Human   250 FEQLLEEEREKTLTNQTEAELATPEG--IYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCR 312
                |:|...:.||:..:.....|..  ::.||   .....:.|..|:|   |..|..|  |.||
  Fly   239 ----LQEGSVENLTDCLKELSQDPNNSLVHLRP---RKSPTMIEQGCQG---KFPPGPQ--LVCR 291

Human   313 YHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVA 377
            | :....|.:.|||.|||:....|.|..|:||:.|.||.::..:.:.::...|..:..|
  Fly   292 Y-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTT------ 349

Human   378 SYRVSKSSWLEEDDD---PVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDER 439
            ..||::...::..||   .:...:..||..|:||.|.....|...|||:||.::.|.|:.   :.
  Fly   350 PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYM---DI 411

Human   440 DTFKHL-GTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAA 503
            ..:..| ..|:|:.|||.||:||..||.|:||....||.||||:|:|||||..:|:.:..||||.
  Fly   412 KLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAV 476

Human   504 CPVLVGCKWVSNKWFHERGQEFLRPC 529
            ||.:||.:||..|......|.|.:||
  Fly   477 CPTIVGSRWVLVKSMLNYEQMFKKPC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	31/134 (23%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	62/176 (35%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	31/134 (23%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	61/173 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020