Protein Alignment P4HA2 and PH4alphaPV

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 169/511 - (33%)
• Similarity: 277/511 - (54%)
• Gaps: 30/511 - (5%)

Human    25 TSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKL 89
            ||:..|..|:..|.:|:.:|::|.:..|.||..::.....:.....|:.:..|.||::|:|::.|
  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98

Human    90 VKRLNTDWPALEDLVLQDSAAGF--IANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISR 152
            ::|:|.||...:  :..|...|.  :..:...|:..||..|...|..||.|:|.||.|....||.
  Fly    99 IRRMNRDWIIWQ--LYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISH 161

Human   153 GELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEAT---TTKSQVLDYLS 214
            |.|.|.:|...|:|.|.:.||:..:::.:|.....|:.|.:..::|...|.   .:|::|....:
  Fly   162 GFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYA 226

Human   215 YAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYER 279
            ..:.:|.....||::....|:.:| |:        .:.||::...:|:. :|....|.|..:...
  Fly   227 ETLLKLNQHADALKVVNIALTDNP-HD--------IKLLLKKSEIETMI-RTGTNNAPPVKVQAT 281

Human   280 PVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDV 344
            .|.     ..|:..|||:   ..|....:|:|.|:. ..:|.|::||.|.|.....|::|.|:||
  Fly   282 GVP-----TAYQIGCRGQ---FPPSADSKLYCLYNR-TTSPFLILAPLKMELVGLDPYMVLYHDV 337

Human   345 MSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLT 409
            :|.:||:.::.:|.|.|.||||....:|...|...|.||.:|..:..:|:..|:|.|:..:||..
  Fly   338 LSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFN 402

Human   410 VKTAELLQVANYGVGGQYEPHFD-FSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLG 473
            :..:|:||:.|||:||.|:.|:| |::.:...|..   :|:|:||.|.|::|||.|||||||::.
  Fly   403 LYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM---SGDRIATVLFYLTDVEQGGATVFPNIR 464

Human   474 AAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529
            .|::|::|:.|.||||..:|:.|.:|.||||||:||.|||.|||..||.|.|.|||
  Fly   465 KAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	39/132 (30%)
		BamD	159..>272	CDD:443281	23/115 (20%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	76/173 (44%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	39/132 (30%)
		NrfG	179..>256	CDD:443378	15/85 (18%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	6/29 (21%)
		P4Hc	339..510	CDD:214780	76/173 (44%)