Protein Alignment P4HA2 and CG31021

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733392.2
• Gene: CG31021 / 43638
• FlyBaseID: FBgn0051021
• Length: 453
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 127/502 - (25%)
• Similarity: 212/502 - (42%)
• Gaps: 72/502 - (14%)

Human    33 LIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDW 97
            ::..|:.|:|::::|....|.|:..|.::..........:..|.|.||::|:|:::|::.::.||
  Fly     1 MLNLERNLLQNMRDYAEKLEEKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHMHQDW 65

Human    98 PA----LEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPG-TISRGELPG 157
            ..    :||||..: |...:.:|..|   .|..|....||:::..|...|..:|. .:::.|...
  Fly    66 VGWQVYMEDLVAPE-AVQKVESLLPQ---LPQKEAFRKAARSVHSLTQFYGYEPADLVAKDERSS 126

Human   158 TKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQL-G 221
            :.:   ||..||:.:|...|.|.||.....|:     |:.|.....:....:.:.|....:|: .
  Fly   127 SLH---LSPLDCYHLGLELYEEQDYLGAAKWL-----QVAAHNYTLSRHRDLFNPLGAPRWQVYR 183

Human   222 DLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPE 286
            ||.|.|....|..:.| ::|.|   ||     |..:....:....:.||.:.....|..:|..|:
  Fly   184 DLGRTLLKLNRQCAYD-AYESA---LR-----LNSQNVHLMKEAGQMELFSLRDPMEPILDLQPK 239

Human   287 RDVYESLCRGEGVKLTPRRQKRLFCRYH---HGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDE 348
            ..|.|..||||    .||.|.||.|..:   |.    .|..||.|.||....|.|:.|...:.::
  Fly   240 PTVLEKYCRGE----VPRHQGRLTCELNDWVHS----FLAYAPIKFEDLQQDPFIILYPGSIYEQ 296

Human   349 EIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTA 413
            ||..::...:    |....|.....|.::...:|      :...||:.|:|.|:..:.|:. ||.
  Fly   297 EIRHVENAYE----RCPPNDRFELKLGISGCSIS------DGYSPVLKRINERILDMAGVE-KTW 350

Human   414 ELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGN------RVATFLNYMSDVEAGGATVFPDL 472
            :...:..|.....:|| |...||..:  |..|...|      :|..||   .||..|||...|:.
  Fly   351 DTFYIVEYAQLAPFEP-FKLFRNSTK--FPKLNLMNFEDVEAKVIIFL---KDVTLGGAFTMPNG 409

Human   473 GAAIWPKKGTAVFWYNLLRSGEGDYRTRHAA--CPVLVGCKWVSNKW 517
            ...:.||:|      |:|.:.|.:   .|:.  ||::.|...|..|:
  Fly   410 DILVQPKRG------NVLITFENE---EHSTTICPIIEGTGLVMIKF 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	31/128 (24%)
		BamD	159..>272	CDD:443281	27/113 (24%)
		TPR	207..240		8/33 (24%)
		P4Hc	346..519	CDD:214780	44/180 (24%)
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:462433	30/121 (25%)