Protein Alignment P4HA2 and PH4alphaNE2

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 170/571 - (29%)
• Similarity: 258/571 - (45%)
• Gaps: 74/571 - (12%)

Human     1 MKLWVSALL-MAW----FGVL--SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKI 58
            |..|...|| |.:    ||.|  :..|..|..|:.:|.|::..|.:||.::::.......|...|
  Fly     1 MLFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTI 65

Human    59 KSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFF 123
            |....||.....:..:..| ..|:|::.:.|::.:.::|  |..|:..::..|       |.:.|
  Fly    66 KWGVFKMMKRRQEYKSSME-IFANPIDTFSLIRHMQSNW--LMWLLYLETPVG-------QEELF 120

Human   124 PTDE---------DEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNE 179
            ..|.         |.|.||:.:.::|.||::....|::|.|.|.:|.:.|...||..:|....|.
  Fly   121 FVDSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNN 185

Human   180 GDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHR--------------ALELT 230
            ..:|....|       :.|..||...||...|.......:|.||.|              ||:..
  Fly   186 SRWYAAEQW-------ISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAY 243

Human   231 RRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCR 295
            :..|.|.|.....     |.|..:.|:|:.||::      ..|   .|:..|...||.|....|.
  Fly   244 QVALKLSPHDPEI-----YEEYRILEKRDLTLSD------IEP---IEQDKDNSHERLVLPPCCS 294

Human   296 GEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK 360
            |.  ...||....|:|.|:|.. :|.|.:||.|.|.....|.:|..:|::|.:|...|:..:|..
  Fly   295 GR--CQVPRNLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEH 356

Human   361 LARATVRDPKTG--VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGV 423
            :..:...||...  ...|.:||.|||.|...|.:....::..|:...|||.:.:.|..||.|||:
  Fly   357 MLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGL 421

Human   424 GGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYN 488
            ||.:|.|.|...: |::.|.  ||.:|:||.|.|:::|..||.|.||.|...::|:.|:|:||||
  Fly   422 GGFFETHLDMLLS-EKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYN 483

Human   489 LLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC-----GSTEV 534
            |...|.....:.|..|||:||.|||.:||.::.||||.|||     .|.||
  Fly   484 LDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEV 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	32/139 (23%)
		BamD	159..>272	CDD:443281	29/126 (23%)
		TPR	207..240		11/46 (24%)
		P4Hc	346..519	CDD:214780	65/174 (37%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	32/139 (23%)
		TPR repeat	175..200	CDD:276809	6/31 (19%)
		TPR_16	176..254	CDD:433202	19/84 (23%)
		NrfG	217..>260	CDD:443378	10/47 (21%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		P4Hc	342..513	CDD:214780	64/173 (37%)