DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P4HA2 and CG15539

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	152/526 - (28%)
Similarity:	247/526 - (46%)	Gaps:	61/526 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    19 VQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAH- 82
            ::..:..||..|:.||..|..|:..|:::       .:.::...:.:|.....:..|.|..||.
  Fly    26 LENNYAISIYDMSKLIDYEHYLLNILQKF-------ANALQKRVDTLEYYLEMTDYDREKNLAED 83

Human    83 PVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDP 147
            |:..:::.:||::|:......:.:......:.::.......||.:|...|.:.|..:|.||.|..
  Fly    84 PIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPT 148

Human   148 GTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQ---- 208
            ..:::|.|....:...|....|..:.|...|..|:.....|:...||..:|.||.....||
  Fly   149 AEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMP 213

Human   209 ----------VLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLT 263
                      :.|.|......:.:|..|::.....:||..:..|...|:|..::..|::.:
  Fly   214 LVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQRALSRLKMNIRIGKEPAEKKNK---- 274

Human   264 NQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFK 328
                                  .:.||:..|..|     .|...:|:|.| ....:..|.:||.|
  Fly   275 ----------------------SKRVYKKCCSSE-----CRPTAKLYCLY-KTTSSYFLRLAPLK 311

Human   329 EEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDP 393
            .|.....|::|.::||:||::|..|:.:.|.|||| ||...|.|..|....|.:|.:||.| ::.
  Fly   312 MELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLAR-TVTVSKDGNYTEDPDRTTKGTWLVE-NNA 374

Human   394 VVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYM 458
            ::.|:::..|.:|...:..|:..||.|||:||.|..||||..:.|.|.|     .:|:||.:.|:
  Fly   375 LIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELDNF-----SDRIATAVFYL 434

Human   459 SDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQ 523
            |||..||||:||.||.:::||||:|:.||||...|:||.||.|:|||.:||.:||..||.:||.|
  Fly   435 SDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQ 499

Human   524 EFLRPC 529
            .|.|||
  Fly   500 IFRRPC 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	27/129 (21%)
		TPR	207..240		8/46 (17%)
		P4Hc	346..519	CDD:214780	77/172 (45%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	27/129 (21%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	76/171 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020