Protein Alignment P4HA2 and PH4alphaNE1

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 191/540 - (35%)
• Similarity: 298/540 - (55%)
• Gaps: 70/540 - (12%)

Human    21 AEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVN 85
            :::|:||..:.||::.|:.|.:.|:..:...:..|.:::|..:.:|...:.:|:|.|.||.:|||
  Fly    21 SDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEHTMAASDTENYLTNPVN 85

Human    86 AYKLVKRLNTDWPALE---DLVLQDSAAGFIANLSVQRQF---FPTDEDEIGAAKALMRLQDTYR 144
            .|:|:|||:|||..:|   .|:.::      .|.:..|::   :|:.||..|||.||:|||.||:
  Fly    86 VYRLMKRLHTDWSLMEGRVQLMAEE------MNFNATREYGLSYPSQEDVEGAALALVRLQSTYK 144

Human   145 LDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQL------------- 196
            ||...:::|.|.|.||.:.:|..|||.:|:..:...||.:|.:|:.:.:::|
  Fly   145 LDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRESMERLRRQTSHAPSHLAP 209

Human   197 DAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKT 261
            .:|.:..|...  ::..:.::|||||...|.||::|:|..||                     |.
  Fly   210 TSGPDTVTLNK--MEATAKSLFQLGDFDTAFELSQRVLQFDP---------------------KR 251

Human   262 LTNQTEAELAT--PEGIYERPVDYLPERD----------VYESLCRGEGVKLTPRRQKRLFCRYH 314
            :.|....:..|  ||.|.:   .|||:..          .||.:||||   :.|..::.|.|||.
  Fly   252 IRNWHLGDKGTAPPEDIDD---VYLPKHSDSYSLSQEFAKYEKVCRGE---VHPIVRQELRCRYS 310

Human   315 HGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASY 379
            .||. |...:||.|.|:....|::..::|::|..:|.:::|:|.|::.|:||.....|.|..:::
  Fly   311 RGNH-PYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPLPGGQLKKSAF 374

Human   380 RVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKH 444
            ||||::||..:..|.:..:.|.::..|||.....|.||||||||||.||||:||.|:......:.
  Fly   375 RVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHWDFFRDPNHYPAEE 439

Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVG 509
               |||:||.:.|:|:||.||||.||.|..|:.|:.|..:|||||.||.:.||||:||.||||.|
  Fly   440 ---GNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVLKG 501

Human   510 CKWVSNKWFHERGQEFLRPC 529
            .||:.|.|.||..|.|.|||
  Fly   502 SKWIGNVWIHEVTQTFARPC 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	47/136 (35%)
		BamD	159..>272	CDD:443281	28/125 (22%)
		TPR	207..240		12/32 (38%)
		P4Hc	346..519	CDD:214780	80/172 (47%)
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	47/136 (35%)
		P4Hc	341..511	CDD:214780	80/172 (47%)