DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P4HA2 and PH4alphaMP

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	202/561 - (36%)
Similarity:	300/561 - (53%)	Gaps:	77/561 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     3 LWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEA 67
            |....:|.....|||| ..|||:|...:..|...|..|:..|:.|:       ::|...|   ||
  Fly     2 LLAKCVLFLVLQVLSC-HGEFFSSTSGLAKLFETEVVLLAELQNYV-------NEINQHA---EA 55

Human    68 LTSK---------SAADA-EGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSA--------AGFIA 114
            |.|:         :|||. :.||.:||||::|:|||::||...|..|..||:        |....
  Fly    56 LQSEIDAIRVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKE 120

Human   115 NLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNE 179
            |||     ||:.:|.:|:|.||.|||.||:||...::.|.|.|.||...:|..|||.:|:..|..
  Fly   121 NLS-----FPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYAL 180

Human   180 GDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAV---FQLGDLHRALELTRRLLSLDPSHE 241
            .||.|||.|::|.::.|  ||::..::|..||::...|   .::|....||.|...:||::|...
  Fly   181 RDYNHTVPWLQQSMQLL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPDQR 243

Human   242 RAGGNLRYFEQLLE--EEREKTLTNQTEAELATPEGIY----ERPVDYLPERD--VYESLCRGEG 298
                     ..|||  ::.|:.:|:      ....|:.    .||.||...|:  :||.:||||.
  Fly   244 ---------SHLLEARQQLEELITD------GDKNGLLHLTARRPGDYHESREFRMYEQVCRGEL 293

Human   299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLAR 363
            ..| |.:|:.|.||.    |..:|..||||.|:....|.:|:.:.|:..::.:.:::.|:|::.|
  Fly   294 APL-PSKQRNLRCRL----RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKR 353

Human   364 ATVRD-PKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQY 427
            :||.. ...|..|.|::|.|:.:......:.....::|.:...:||.:..||.|||||||:||.|
  Fly   354 STVYSLGGNGGSTAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHY 418

Human   428 EPHFD-FSRN---DERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYN 488
            |||:| |..|   .|.|..     |||:||.:.|::||||||.|.||.|...:.|::|:.:||||
  Fly   419 EPHWDSFPENHIYQEGDLH-----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYN 478

Human   489 LLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529
            |..||:.|:||:|||||||.|.||::|.|..||.|:.:|||
  Fly   479 LHPSGDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	50/146 (34%)
		TPR	207..240		11/35 (31%)
		P4Hc	346..519	CDD:214780	73/177 (41%)
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	50/146 (34%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	73/177 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3267
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980