Protein Alignment P4HA2 and PH4alphaSG2

DIOPT Version :9

• Sequence 1: NP_001136071.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 174/540 - (32%)
• Similarity: 267/540 - (49%)
• Gaps: 53/540 - (9%)

Human     9 LMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWAN--KMEALTSK 71
            |:.|.||   ...||::|:..|.||...|:||:.:.:.|:..::.:|...:.:..  |.|...:.
  Fly    14 LIIWVGV---ANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWAT 75

Human    72 SAADAEGYLAHPVNAYKLVKRLNTDWPAL--EDLVLQDSAAGFIANLSV-QRQFFPTDEDEI-GA 132
            |....:.||.||::|::|:|||..||.:|  |.::..::...|.|.:.| .|.....|:.|: ||
  Fly    76 SQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGYPDQSELQGA 140

Human   133 AKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQ--VLKQ 195
            .|.|.|||..|.|....::.|.:.|..|.:.|...:|:.:|...::.|:|..::.|::.  :|.:
  Fly   141 IKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLR 205

Human   196 LDAGEE--ATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFE-----QL 253
            ....||  |....|.:.:|.|.|.|:||:..:|..|..::|...|:|. |....:|.|     :.
  Fly   206 NSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTHS-AQQTQKYLESRVPGKN 269

Human   254 LEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNR 318
            ::|.:....:|                         |..||:|.  :|...|.......|..|.|
  Fly   270 VQETKPSWFSN-------------------------YTRLCQGR--RLPEERSGDPLRCYLDGKR 307

Human   319 APQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERI-KEIAKPKLARATVRDPKTGVLTVASYRVS 382
            .....:||.:.|.....|.|..|:.::|.::|..| :|..|.::.|:.|.. ..|..||...|||
  Fly   308 HAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAG-SGGEGTVRDLRVS 371

Human   383 KSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGT 447
            :.:||:. ..||:..|.|.:|.::|..:..||.:||||||||||||||.|:...:....|:
  Fly   372 QQTWLDY-KSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFE---- 431

Human   448 GNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKW 512
            |:|::|.:.|:||||.||.|||..|...:.|.||..|.|:||.||...|.||.||.|||:||.|.
  Fly   432 GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKR 496

Human   513 VSNKWFHERGQEFLRPCGST 532
            :.|.|.|...|||.|||..|
  Fly   497 IGNIWMHSGYQEFRRPCNLT 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	41/134 (31%)
		TPR	207..240		11/32 (34%)
		P4Hc	346..519	CDD:214780	75/173 (43%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	41/134 (31%)
		P4Hc	335..503	CDD:214780	75/173 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920