DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P4HA2 and CG11828

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	131/515 - (25%)
Similarity:	228/515 - (44%)	Gaps:	74/515 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    30 MTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLN 94
            |..|:..|.||:..:::|.:..:.|::.::::..:.....:...||...|:|:|:.::.|::|..
  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65

Human    95 TDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIG------AAKALMRLQDTYRLDPGTISRG 153
            ||.|.|.:|..::...|..      ::|...|...|.      |...::|.|..|.:|...::.|
  Fly    66 TDVPKLLELAREEFKPGPF------QKFIDYDLSSISDVELETAVTGMLRFQGVYGMDESEMANG 124

Human   154 ELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLW----MEQVLKQLD-AGEEATTTKSQVLDYL 213
            :|.|.:|.:.:|..||..:.....|.........|    ::|..::|| ......|.:||:.:.|
  Fly   125 KLHGKQYNSRMSAADCLAVATHLENVDKGKLACKWFKVAIDQYEEKLDPVNRLLQTGRSQIYEKL 189

Human   214 SYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYE 278
            ...:..:.||              |:.:.|      |...:     ...:.:...:||      :
  Fly   190 GLTLLAMHDL--------------PASQAA------FRDSI-----GWASKEDNTDLA------K 223

Human   279 RPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYD 343
            ...|.|....|:...|||:  .|.|.: ..|.|||.. :.:|.|.:||.|.|.....|.:..::|
  Fly   224 HLKDKLAHMFVHVDNCRGK--NLLPSK-SYLRCRYLR-DGSPFLRMAPVKLEQLNIEPFVGLFHD 284

Human   344 VMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD----PVVARVNRRMQH 404
            .:|..|.:.:..:...:|                .:|...||.:|...|    ..|.|:::|::.
  Fly   285 AISPAEQKDLLHLTDSRL----------------EHRKKDSSSVEAKVDTNASDHVRRIHQRIED 333

Human   405 ITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVF 469
            |||..::.:|.|.|:|||:|||...|.|..:  .::...:.....|.|:.:.|:|||:.||...|
  Fly   334 ITGFDLEESEPLTVSNYGIGGQDFIHLDCEQ--PKEFIGYYPKEYRSASAMFYLSDVQMGGYASF 396

Human   470 PDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529
            ||||....|::|:|:.|:|...||..|.|:..|.||||:|.:||:.||....||...:.|
  Fly   397 PDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	29/130 (22%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	57/176 (32%)
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	29/130 (22%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	56/175 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020