Protein Alignment P4HA2 and CG32199

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_730347.1
• Gene: CG32199 / 40028
• FlyBaseID: FBgn0052199
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 153/528 - (28%)
• Similarity: 256/528 - (48%)
• Gaps: 44/528 - (8%)

Human    23 FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAY 87
            :.||:..|..|:..|:.|..:|..|:...::||..||.:.:.::.:|..:..:.|.|:::|:||:
  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67

Human    88 KLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISR 152
            .:::|||.|||.....:....|:..|..:.||.:..|.|:|...|.|.:.|::..:.|....:::
  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132

Human   153 GELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAV 217
            |.|.|.|..:.|:..||..:|...||:..:..:..|....|:        ..|..:.:.|.....
  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALR--------VHTHPRGMIYAKVLG 189

Human   218 FQLGDLHR--ALELTRRLLSLDPSH----ERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGI 276
            .:...:::  |..|.:..|:.|.|.    |::..| |..:::..|:....:....:..|:..|.|
  Fly   190 LKRKRIYKKYAKALLKESLNSDKSKPTPTEKSEWN-RLAKEVTREDNYDNVKKLIDEYLSGDEKI 253

Human   277 YERPVDYLPERDV-YESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVR 340
            ::.....|..:.. .|..||||..|   :....|.|||:....| .|.:||.|.|.....|.|:.
  Fly   254 FQEVAARLKRKPTKLERGCRGEWPK---KSSPELICRYNRDTSA-FLKLAPLKLEFLSVQPMILL 314

Human   341 YYDVMSDEEIERIKEIAKPKLARATVRD------------PKTGVLTVASYRVSKSSWLEEDDDP 393
            |:||:.:.|.:.:::||   :...::.|            ||      ...||.|....:....|
  Fly   315 YHDVLYENEFKSMRDIA---MYNGSMIDGWTYVDFDKKGNPK------QQDRVVKMIAFQGTTAP 370

Human   394 VVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDER--DTFKHLGTGNRVATFLN 456
            ....:||||..::||.::...:|.:.|||:||.:..|.|:....:|  |.|...| |:|:||.|.
  Fly   371 FTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFG-GDRIATALI 434

Human   457 YMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHER 521
            |.||:..||.|||..|..|:.||||:|:.|:||..:||.|..|.|:.|||::|.:|:.:||.|||
  Fly   435 YASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISKWIHER 499

Human   522 GQEFLRPC 529
            .|.|.:||
  Fly   500 QQVFKKPC 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	36/130 (28%)
		BamD	159..>272	CDD:443281	21/118 (18%)
		TPR	207..240		5/34 (15%)
		P4Hc	346..519	CDD:214780	63/186 (34%)
CG32199	NP_730347.1	P4Ha_N	6..137	CDD:462433	36/130 (28%)
		P4Hc	<369..497	CDD:214780	54/128 (42%)