Protein Alignment P4HA2 and CG18231

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_649045.2
• Gene: CG18231 / 40026
• FlyBaseID: FBgn0036796
• Length: 470
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 127/532 - (23%)
• Similarity: 225/532 - (42%)
• Gaps: 143/532 - (26%)

Human    24 FTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYK 88
            ::||..:..|:..|:..:.::|.|......|:..::::.:.::....:|..|.|.|:.:|:||:.
  Fly    17 YSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFS 81

Human    89 LVKRLNTDWP----------------ALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALM 137
            ||:|.:.|.|                |||:::.:                .|..:|...:...:.
  Fly    82 LVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAK----------------VPDKKDMAYSLGEMH 130

Human   138 RLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEA 202
            |::..|.|:...::||.:.|.:|....|:.||..:|...:...||....:|....:|....|
  Fly   131 RIEQIYDLEAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEG--- 192

Human   203 TTTKSQVLDYLSYAVFQLGD-------LHRALELTRRLLSLDPSHERA-----------GGNLRY 249
               .:::::.:      |||       |:....|...::..:||...|           ..:|..
  Fly   193 ---NAEIINSI------LGDPKVNLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLAD 248

Human   250 FEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYH 314
            .:.||.|     |.:||:.|:     :||..|:.....| ||..|||:.:     |::...|.|:
  Fly   249 IKSLLNE-----LLSQTDDEI-----VYEMNVNKTKPSD-YEIGCRGQFL-----RRRNHVCTYN 297

Human   315 HGNRAPQLLIAPFKEED-EWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVAS 378
            . .....|.:||.|:|. .|| |:||.|:||::|:||:::|
  Fly   298 F-TITEFLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLK------------------------ 336

Human   379 YRVSKSSWLEEDD----DPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFD---FSRN 436
                  :.|.:.|    :|:..|:.:|:..:|.|:.:                  |.|   .|:|
  Fly   337 ------NHLNDTDAVEVNPIEKRIFQRINELTRLSFE------------------HSDQQIVSKN 377

Human   437 DERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRH 501
            ..| |.||.....: .|.|.::::||.|||.|||.|..:::|:||:.:||:|.|     |.|:..
  Fly   378 GPR-THKHKKEYLK-GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEP 435

Human   502 AACPVLVGCKWV 513
            ..||||.|.|.|
  Fly   436 LECPVLQGNKRV 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	29/146 (20%)
		BamD	159..>272	CDD:443281	26/130 (20%)
		TPR	207..240		6/39 (15%)
		P4Hc	346..519	CDD:214780	46/175 (26%)
CG18231	NP_649045.2	P4Ha_N	19..150	CDD:462433	29/146 (20%)
		2OG-FeII_Oxy	322..449	CDD:473886	49/181 (27%)