Protein Alignment P4HA2 and CG18233

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_649044.3
• Gene: CG18233 / 40025
• FlyBaseID: FBgn0036795
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 147/527 - (27%)
• Similarity: 262/527 - (49%)
• Gaps: 69/527 - (13%)

Human    23 FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAY 87
            :.:|:..:..|:..|:|.:.:...|..:.:.|:..:..:.:.::....|:..:.|.::::|:||:
  Fly    31 YSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNPLNAF 95

Human    88 KLVKRLNTDWPALED-----------LVLQD--SAAGFIANLSVQRQFFPTDEDEIGAAKALMRL 139
            .|::|||.|||.|::           ..:||  |||             |...|.....||:.|:
  Fly    96 GLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAA-------------PESFDMNEKLKAMHRI 147

Human   140 QDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATT 204
            :.||.|.|..|::|.|..|::...|...||..:....:..|::..::||.::.||....|.....
  Fly   148 ETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIM 212

Human   205 TKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLR-----YFEQLLEEEREKTLTN 264
            .:.:.::...:|.   ....|::.|:.:.|:.:...:.|...|:     ..|||:..|.::.:.:
  Fly   213 NRLKEIELKGFAT---AVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISSELKQWIND 274

Human   265 QTEAELATPEGIYERPVDYLPERDVYESL-CRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFK 328
            .:    .||      |.|:        :| |||    |.|:: ..|.|||:....| .|.:||.|
  Fly   275 DS----TTP------PTDH--------NLGCRG----LFPKK-SNLVCRYNSSTNA-FLKLAPLK 315

Human   329 EEDEWDSPHIVRYYDVMSDEEIERIK-EIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD 392
            .|:....|:||.:::|:||::||.:| ||.:.:....::.|||.        .||:..|:.::..
  Fly   316 MEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPKE--------IVSRVYWIRKESS 372

Human   393 PVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNY 457
             ...|:|:|:..:||..::....:|:||:||||.::||:||..:..::...:...|:|:.:.:.|
  Fly   373 -FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTLGDRIGSIIFY 436

Human   458 MSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERG 522
            ..:|..||.||||||..|:.||||.|:||:|.......|.|:.|:.||||||.:|...||.|...
  Fly   437 AGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAP 501

Human   523 QEFLRPC 529
            |.|::||
  Fly   502 QLFVKPC 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	36/143 (25%)
		BamD	159..>272	CDD:443281	19/117 (16%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	62/173 (36%)
CG18233	NP_649044.3	P4Ha_N	34..164	CDD:462433	35/142 (25%)
		P4Hc	333..498	CDD:214780	62/173 (36%)