Protein Alignment P4HA2 and CG18234

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_649043.3
• Gene: CG18234 / 40024
• FlyBaseID: FBgn0265268
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 146/532 - (27%)
• Similarity: 236/532 - (44%)
• Gaps: 91/532 - (17%)

Human    26 SIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLV 90
            ||..|.:|:..|...:..::.|....:.|:..::|...::::....|..:.|.::|||:||:.|:
  Fly    27 SIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLI 91

Human    91 KRLNTDWPALEDLVLQDSAAGFIANLSV-QRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGE 154
            :||:.||...|.|:|.......:..:.. ..:..|:|.|...|...::.||..|.|.|..|:.|.
  Fly    92 RRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGL 156

Human   155 LPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQ 219
            |.|.:|.|.|:..:|..:..:..|.....:.:.|.:..:...:...:....: :|.|      |:
  Fly   157 LMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYR-EVFD------FR 214

Human   220 LGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTN--QTEAEL-ATPEGIYERPV 281
            |.||:                      :.|...|:.:...|....  |..|:| ||.
  Fly   215 LPDLY----------------------INYTSVLVTKGFRKAAWKVLQDVADLDATL-------- 249

Human   282 DYLPERDVYESLCRGE-----------------GVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKE 329
             :|..:|:||.   |:                 |.....:..:.|.|.|.. |.:..|.|||.|.
  Fly   250 -WLLRKDIYEV---GKIDVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEK-NTSEFLRIAPLKV 309

Human   330 EDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPV 394
            |.....||||.|:||:.|.||.::|.|:.|.| ::.:|     :|....|.:..:...|:...|
  Fly   310 ETLSLKPHIVLYHDVIYDSEISKVKNISLPSL-KSPLR-----ILYAIDYNLKFAKIREDHQSP- 367

Human   395 VARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDE-RDTFKHLGTGNRVATFLNYM 458
               ::.|::.:||..|:.....|:.|||:.|....|.|   |.| :|....|  |:|:.:.:.:|
  Fly   368 ---LSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTD---NIELQDQTAEL--GDRLTSIMFFM 424

Human   459 SDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTR------HAACPVLVGCKWVSNKW 517
            :||..|||..||:|...|||:||:|:.|.||      |:|.:      |.:|||:||.||...||
  Fly   425 NDVAQGGALAFPNLNLTIWPQKGSALVWRNL------DHRMQPNQDLLHVSCPVVVGSKWTLVKW 483

Human   518 FHERGQEFLRPC 529
            .|||.|.|.|||
  Fly   484 LHERPQMFSRPC 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	35/131 (27%)
		BamD	159..>272	CDD:443281	18/115 (16%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	59/179 (33%)
CG18234	NP_649043.3	P4Ha_N	27..159	CDD:462433	35/131 (27%)
		P4Hc	<371..485	CDD:214780	47/124 (38%)