Protein Alignment P4HA2 and CG4174

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_730342.2
• Gene: CG4174 / 40023
• FlyBaseID: FBgn0036793
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 129/507 - (25%)
• Similarity: 214/507 - (42%)
• Gaps: 76/507 - (14%)

Human    22 EFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNA 86
            :|..|......|:..::..|.:|:.|..|.:..|.||:....:.|.|...:.......    :..
  Fly    28 DFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYG 88

Human    87 YKLVKRLNTDWPAL-----EDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLD 146
            ||:::.|:.|||..     :||.|:..|   ::.:.:.:|  ||..|...:..|:.|||..|.||
  Fly    89 YKVLRHLHNDWPQYFRLLKKDLGLEQIA---VSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLD 148

Human   147 PGTISRGELPG-TKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVL 210
            ...::.|.:.. .|.....|.|:|..:|.......||..:..|:|..|...|........|.::.
  Fly   149 SYAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIKLW 213

Human   211 DY------LSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAE 269
            :|      |..|...||....|.:....|||::|:|......|...:.|          ....|:
  Fly   214 NYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLKHL----------QSNPAK 268

Human   270 LATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWD 334
            |..|:.:::          :.:.:|.    |...|:...|.|||  .:..|.|.:||.|.|:...
  Fly   269 LTKPKKVFQ----------LQKEICS----KRYRRKSGVLVCRY--VDWTPFLKLAPLKMEELSM 317

Human   335 SPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVN 399
            .|:|..:|..:..::||.:|.:::|||.|.   :..:|   ..|.::...|....|   ||.:||
  Fly   318 KPYISIFYGFLGQKDIEVLKNVSRPKLQRI---EHLSG---NCSCKIGNLSTSLHD---VVRKVN 373

Human   400 RRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAG 464
            ..:..|||..:|..::|:|.|||:.|.|.|         .:...|    |:...|: ::|:...|
  Fly   374 ELILGITGFPLKGNQMLEVINYGIAGNYNP---------EEPKIH----NKANAFI-FLSNAGKG 424

Human   465 GATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNK 516
            |..|||.....:.|:||:.:.|.||.:|      ..:..||:|.|..||:||
  Fly   425 GEIVFPSRHLKVRPRKGSMLVWENLKKS------LIYHQCPILKGNMWVANK 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	33/135 (24%)
		BamD	159..>272	CDD:443281	27/118 (23%)
		TPR	207..240		10/38 (26%)
		P4Hc	346..519	CDD:214780	51/171 (30%)
CG4174	NP_730342.2	P4Ha_N	33..159	CDD:462433	32/134 (24%)
		TPR repeat	169..197	CDD:276809	7/27 (26%)
		TPR repeat	202..245	CDD:276809	9/42 (21%)
		PLN00052	311..>470	CDD:177683	54/187 (29%)